If you have been obsessing over the origins of #SARSCoV2 -- including the "lab leak theory" -- you need to read this very important new paper:
zenodo.org/record/5075888…
It's written by scientists whose life work is figuring out where viruses come from.
MORE
2/ They conclude:
"there is a substantial body of scientific evidence supporting a zoonotic origin for
#SARSCoV2. While the possibility of a laboratory accident cannot be entirely dismissed...this conduit for emergence is highly unlikely relative to the
numerous..."
MORE
3/
"...& repeated human-animal contacts that occur routinely in the wildlife trade. Failure to investigate the zoonotic origin thru collaborative & carefully coordinated studies wld leave the world vulnerable to future #pandemics arising frm the same" animal/human interactions.
4/ I tagged some of my photos shot in the market that SARS arose from in 2003 in Guangzhou, where I found 100s of caged species, handled cavalierly by barehanded, barefooted wildlife dealers. Here are a few more, shot by me.

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More from @Laurie_Garrett

25 Jun
European threat assessment of #DeltaVariant #COVID19 :
"Based on the available evidence, the #SARSCoV2 Delta (B.1.617.2) variant of concern (VOC) is 40-60% more transmissible than the Alpha (Β.1.1.7) VOC and..."
MORE
ecdc.europa.eu/sites/default/…
2/
"...may be associated with higher risk of hospitalization.
Furthermore...those who have only received the 1st dose of a 2-dose #vaccination course are less well protected against infection w/the #DeltaVariant than against other variants, regardless of the vaccine type."
MORE
3/
"However, full vaccination provides nearly equivalent protection against the #DeltaVariant. Based on the est'ed transmission advantage of Delta...
70% of new #SARSCoV2 infections are projected to be due to this variant in the EU/EEA by early August & 90% by the end of August."
Read 4 tweets
24 Jun
As the incidence of #DeltaVariant #SARSCoV2 rises in the US, India says a worse, "Delta+" strain has emerged that bypasses the @AstraZeneca #vaccine .
Meanwhile, the #COVID19 crisis in India begat a mucormycosis -- "black fungus" -- nightmare.
MORE
washingtonpost.com/world/interact…
2/
It reminds me of the early days of AIDS and cryptococcosis pneumonia. Both fungal infections arise when patients' immune systems are weakened.
“It’s a form of flesh-eating fungus that destroys tissues as it grows. If it involves the sinus, they have to be cleared."
MORE
3/ "If it involves the eye — the eyeball, lids, muscles around the eye have to be removed, leaving behind the bare, bony socket.”
The drug used for treatment, amphotericin B, is expensive, in short supply, is infused & has lots of side effects.
MORE
Read 4 tweets
22 Jun
Whooo-boy, this preprint by Jesse Bloom is going to roil the waters of #SARSCoV2 origins debates. biorxiv.org/content/10.110…
It's complicated, but I will try to walk thru some key points. Bloom -- who was part of a group of scientists that recently demanded better scrutiny of...MORE
2/...the origins of the Dec 2019 Wuhan #SARSCoV2 outbreak, found 13 early viral genomes on Google iCloud that had been deleted -- mysteriously -- from NIH’s Sequence Read Archive. The sequences were collected in Jan2020 by Aisu Fu and Renmin Hospital of Wuhan University.
MORE
3/ Bloom interrogates Googled genomes, comparing them to ones in the public record, & concludes they are more bat-like & show no connection to the Wuhan animal market. His Pre-print takes a dark turn. I quote: "Crucially, both putative progenitors are 3 mutations closer.." MORE
Read 8 tweets
22 Jun
The @TheLancet has created a #COVID19 Commission, with mostly predictable members, chaired by Jeffrey Sachs. covid19commission.org/commissioners It has 12 Taskforces. One studies viral origins debate-- its 1st rpt has no conclusions, but a research wish-list.
MORE
static1.squarespace.com/static/5ef3652…
2/ There are now so many #COVID19 intl commissions & task forces out there that I doubt anyone can keep track, or read all their reports. Everything is couched in UN-speak -- "might have," "could have", "may in the future."
Jeff Sachs writes:
"The question about origins..."
MORE
3/ "...is not about one govt or another, much less a geopolitical issue or a matter of blaming China & exonerating the US. If there was indeed a laboratory-related release of #SARSCoV2, it may well have occurred in a project funded by the US govt, using methods developed..."
MORE
Read 6 tweets
17 Jun
The African population of 1.3 billion has received <0.6% of the world's #COVID19 #vaccine doses. The African Union has a $2B fund for purchase of vax, but nobody will sell to them because Europe & US & Canada have contracted for the entire global supply.
MORE
2/ Despite promises made at #G7 most of the world, especially Africa, won't get #COVID19 #vaccines until 2022-23.
Meanwhile, Africa's economy is collapsing & countries are losing 20 years of development. The @IMF has loaned Europe the equivalent of $2300/person for...
MORE
3/...#COVID19 recovery, but promised Africa only $27/person. One top African officials said today to us, "Rich countries are hording vaccines & hording cheap cash. This is not global order, it is hording."
No justice.
No equity.
No survival?
Read 4 tweets
13 Jun
A large team of virologists from several insts in China have discovered #SARSCoV2 - like viruses in bats in Yunnan Province. This pre-print contains much of interest.
- 411 bat samples were collected between May 2019 & Nov 2020.
MORE
cell.com/cell/pdf/S0092…
2/
- genome analysis shows 4 novel #SARSCoV2 -related viruses
- 3 of them carry a genetically distinct spike gene that could weakly bind to the human ACE2 receptors in vitro
- and 3 other viruses were found, similar to the one that caused #SARS in 2003

MORE
3/
- the ecological niche for these bats stretches from South Laos & Vietnam & Myanmar to southern China
- genetic sequence identity for #SARSCoV2 and original #SARS of new-found viruses ranges from 94 to 97.7%
- some genomic clustering with pangolin virus seen
MORE
Read 4 tweets

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