Fatima Tokhmafshan Profile picture
Aug 28, 2021 16 tweets 8 min read Read on X
1-Today there was a big protest in Montréal by healthcare workers opposed to mandatory vaccination.

As a healthcare professional & a bioethics I want to underline a few points about #VaccineMandates for healthcare provides
🧵👇🏾
2-In bioethics, autonomy is no longer that centuries-old belief that the individual can or does somehow stand apart from their community, social circumstances & political environment. Also, autonomy has a different scope when intervention in question has implications beyond self.
3-Dr Nedelsky(osgoode.yorku.ca/faculty-and-st…) calls the belief that autonomy is isolated from outside influence a “pathology”: “If we ask ourselves what actually enables people to be autonomous, the answer is not isolation, but relationships—with parents,
teachers, friends, loved ones.”
4-I love this statement by Mildred Solomon & Bruce Jennings: “Independence relies on interdependence.”
This societal interdependence combined w/ the biological one (communicable disease) ➡️decision to receive/refuse the #CovidVaccine implicates societal autonomy not personal ones
5-Autonomy in a PH is about a structured environment that provides options, good information, & the
absence of manipulation of preferences
by self-interested outsiders (misinformation, grifters).
6- Misinformation & pseudoscience in general have long gone hand-in-hand w/ extreme epistemological
relativism, where people are encouraged to believe that they should decide not merely what they want to
do, but what the facts are about #ClimateChange, #vaccines, supplements, etc
7-This is indeed a clever marketing scheme‼️
e.g. in 2010, the 🇺🇸 Federal Trade Commission
charged Pom Wonderful with
false advertising b/c of its unsupported
claims that its pomegranate
juice prevents heart disease &
erectile dysfunction & can “cheat
death.”🤯
8-In response, Pom ran new ads, telling consumers when it comes to "FTC v. POM - You be the judge." Which is of course completely ludicrous b/c the average person does not have the skills or resources to run a randomized longitudinal trial & ascertain the truths of the claims.
9-Above is an example of false autonomy: illusion of individual
choice that in fact limits INFORMED
decision-making & hence autonomy.
You are made to believe you’re given the independence of choice, when in reality, you lack the devices to make informed choices.
#Ivermectin
10-Many healthcare providers that oppose #VaccineMandates do so on the basis of the assumption that it violates their autonomy.
But we just established that:
📌autonomy doesn’t exist in isolation
📌if one lacks devices to make informed decision, one lack true autonomy
11-HCW have a fiduciary responsibility to “do no harm”. Patients have an absolute right to non-maleficent care.

Autonomy of the patient & HCW are interdependent & any personal decisions that endangers the wellbeing of the other person is unethical & grounds for legal action.
12-So autonomy is NOT a valid argument.
What about other ethical considerations?
When mandating vaccines, 3 broad bioethical questions should be addressed:
Q1: Can the population be protected w/o the mandate?
Q2: Is the compound safe & effective?
Q3: Is equity met?
13- Q1:Vaccination rates have plateaued & some in allied health remain unvaccinated. Given their risk level (to themselves & others) & their responsibility to not cause harm, there is an overwhelming consensus (scientists, clinicians, bioethicist, etc.) that mandates are needed.
14- Q2: The approved vaccines are very safe & effective— this question is NOT up for debate.

The fact that disease risk from infection >>>>> any potential side effects from vaccines is an established scientific fact & you do NOT get to make your own version of it.
15- Q3: this is the most challenging & yet essential issue to address.
📌Offer exemptions for VALID medical reasons
📌Compensate anyone who might suffer vaccine injury
📌Ensure everyone in the mandated population has equitable access to vaccines (#PaidSickLeaves, etc.)
16- In conclusion & in my humble assessment, there aren’t any bioethical hinderances to #VaccineMandates as long as we ensure the #equity aspect is address properly, and that the mandate is enforced firmly but fairly.
#VaccinesSaveLives
#SayYesToVaccines

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More from @DeNovo_Fatima

Jul 22, 2022
👇🏾 mischaracterization of polio detected in sewage and what it actually means‼️

Here are some facts about polio vaccines and the complexities of polio eradication:
1- humans are the only known reservoirs of polio ➡️ it’s a good candidate for eradication
2- currently there are 2 types of polio vaccine:
📌 IPV: inactivated, non-replicative virus
📌 OPV: attenuated (weakened) but replication competent virus

Both have been around for decades and have pros and cons!
3- IPV for instance, whilst being a great at 🛡 against disease doesn’t give good mucosal immunity ➡️ not very effective at stopping transmission
Read 7 tweets
Dec 27, 2021
Pandemic of #unvaccinated, more like #PandemicOfInequities‼️
🧵Below are a few interactions I’ve had in the past year with people who have been left behind by our inequitable approaches and deficit model assumptions and labels.
Shared with consent on the condition of anonymity
1/
Case1️⃣: recent refugees, husband works min-wage in a bakery, wife pregnant and earns VERY modest income through knitting. Have 3 children < 12 yrs old.
Whole family was unvaccinated until recently.
Few months ago, one child was exposed in school. Family didn’t have access to
1/
Case1️⃣ cont’d: #RapidTests & frankly didn’t even know that was an option. Husband couldn’t afford to take a half-day off to get tested even when symptoms emerged. He ended up in ICU—sole bread winner for the family.
Even then the wife was hesitant to vaccinate herself or her
2/
Read 14 tweets
Dec 25, 2021
🔬 Very nice study showing that #Omicron isn’t as efficient in entering cells compared to Delta & ancestral lineages.

👩🏾‍🔬 Why I find this cool: unlike other recent datasets, they’ve used an actual viral isolate (not pseudovirus) in an appropriate cell line & an animal model.
1/
In science using the right models & methods matters, but not all models recapitulate human conditions & no single method can give us the whole picture.
Why does this matter: b/c we tend to over-interpret & over-extrapolate.
So here the only appropriate conclusion is that…
2/
Omicron is not as efficient in cell entry & maybe infecting lung cells.
Does it mean the overall disease is less severe: we don’t know, remember that multiple systems get affected by the disease, looking at lungs alone won’t tell us if for instance clotting is also reduced
3/
Read 4 tweets
Nov 27, 2021
Hearing the news of Omicron cases in Europe in people who travelled through various countries (Malawi, Egypt, Namibia, Dubai, etc.) indicates that Omicron was flying under the radar in undersequenced countries for some time until Botswana & 🇿🇦 detected it & alerted the 🌎.
The thing about pathogen evolution, particularly in obligate cellular parasites, is that detecting new lineages is difficult unless it is being transmitted AND someone is looking for it (biological samples including wastewater)➡️need capacity building in genomic surveillance
We’re lucky to have good genomics capacity (but always more can be done), many countries do not! We MUST help them develop these capacities so they can be continuously monitoring their regional evolution!!
Read 6 tweets
Nov 26, 2021
👩🏾‍🔬Response to the most common question I got today:
The new variant has a lot of mutations, what does this mean in terms of epidemiology & vaccines❓

🧬 short answer: to early to tell‼️

🔬Long, more nuanced answer: whilst having too many mutations, some of which are known to
1/
affect for instance how fast the virus replicates inside our cells or how it interacts with our immune system, it is difficult to say what synergistic effect all those mutations could have when put together, without functional assays coupled with real-world data‼️
2/
Analogy: some vegetables on their own taste quite meh, some combination of those vegetables put together could make an absolutely awful meal, but sometimes you add in a bunch of other ingredients & you get something that’s tolerable‼️
(Can you tell I don’t like vegetables 🙃)
3/
Read 5 tweets
Nov 25, 2021
Worried about new variants?

We got you 🙌🏾

🔬🧬We are the Coronavirus Variants Rapid Response Network @CoVaRR_Net working to accelerate & facilitate our understanding and management of #SARSCoV2 variants of concern!

Visit covarrnet.ca
#TeamCanada #GoTeam #GoScience
Science doesn’t happen in silos & is not one dimensional!
@Covarrnet is founded on the belief that the best science is one that is collaborative & #EDII-centred.
Here are some of the brilliant people who make up @CoVaRR_Net:
@langlois_ma @ninan_abraham1 @JenGommerman @gingraslab1
Read 4 tweets

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