Let's take a look at the data from the @CDCgov ACIP meeting last week on #COVID19 #vaccine safety in #pregnancy.

It continues to be reassuring!

First, let's take a look at the new data from the V-safe pregnancy registry... 🧵

cdc.gov/vaccines/acip/…
As of the 13th September, the registry contained 5096 participants. 2/ Among 5096 people in the re...
After they have joined, the participants are interviewed in every trimester, shortly after giving birth, and again when their babies are more than three months old. 3/ Participants are interviewe...
First, they go through the data showing that, among 2456 people vaccinated before 20 weeks, the risk of miscarriage was normal.

This has been recently published and you can read about it in more detail here... 4/

But there is one additional graphic that is quite nice. This compares the week-by-week miscarriage rate in those who received the COVID vaccine, vs two studies of miscarriage rates from before the pandemic.

You can see that post-vax miscarriage rates are bang in the middle. 5/ Miscarriage rates in people...
The next section looks at outcomes for babies at birth.

The registry contains 1634 live born babies. 70% born following 3rd trimester vaccination and 30% following second trimester vaccination. 6/ Flow diagram showing that 1...
Among these babies, the rates of preterm birth, being small for gestational age, admission to neonatal intensive care and infant death are all normal. 7/ Among babies born to V-safe...
45 babies had a birth defect. The types and rates of birth defects were consistent with what is usually seen in the USA. So no evidence of an increased risk of birth defects following vaccination in this cohort. 8/ Image
That's all from the V-safe pregnancy registry! I'm off to do the school run now, but I'll be back later with an update from the Vaccine Safety Datalink... 9/9

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More from @VikiLovesFACS

21 Oct
Stressful times (war, famine) are associated with people experiencing more anovulatory and abnormal menstrual cycles.

But what about the pandemic? This paper used data from 18,076 ppl tracking their cycles with @NaturalCycles app to investigate… 🧵

journals.plos.org/plosone/articl…
The authors looked at user data entered from March - September 2019 (pre-pandemic) compared to March - September 2020 (Pandemic). They also asked users to rate their stress levels (retrospectively) in the pre-pandemic and pandemic periods. 2/
The average cycle length decreased from 29.4 to 29.q6 days, and the average period of menstruation increased from 4.21 to 4.23 days.

Neither of these changes is clinically significant. 3/
Read 13 tweets
17 Oct
Are you #breastfeeding? Thinking about whether to get the #COVID19 #vaccine?

🤱🏾💉🤔

This is a thread for you!

🧵...
People who are breastfeeding can sometimes get forgotten in the focus on pregnancy. But your questions matter too! And I particularly want to make space to address those questions because a lot of people have contacted me, worried about one particular blog post... 2/
I'll get to that later. But let's start by saying that @RCObsGyn and @MidwivesRCM recommend the COVID vaccine if you are breastfeeding. 3/

rcog.org.uk/en/guidelines-…
Read 18 tweets
14 Oct
Wondering if antibodies raised against #COVID19 #vaccines can bind to the placental protein syncytin-1 and harm #fertility?

💉👩🏽‍❤️‍👨🏻🤔

Out yesterday! More data that addresses this question!

Spoiler alert: they don’t... 🧵

nature.com/articles/s4142…
But why would anyone even think that such a thing might happen? Is it even worth researching?

The rumours that COVID19 vaccines would impact fertility were started by a vaccine skeptic who proposed that this might occur, so this is something that a lot of ppl may have heard. 2/
People who work in this area never thought this was very likely, for a number of reasons.

Not least, if this did happen COVID 🦠 would be associated with infertility or problems in early pregnancy, and luckily we don’t see that. 3/

Read 7 tweets
12 Oct
A question I get asked *a lot* is…

“What are the long-term effects on babies born after #COVID19 #vaccination in #pregnancy?”

So let’s talk about what we know… 🧵
Let’s start by looking at the effects at birth. We now have eight large datasets from four countries looking at almost 79,000 people vaccinated in pregnancy. The outcomes for the babies are all normal. 2/
(The CDC has recently put out data from 2 more US studies, bringing the total to 10. But there is some overlap between the participants in these studies and the ones quoted above, so I didn't add those in as unique participants.)

From V-safe... 3/

Read 12 tweets
8 Sep
This study looked at the effectiveness of the Pfizer #COVID19 #vaccine in #pregnancy.

👉🏻 96% effective vs. any infection

👉🏻 97% effective vs. symptomatic infection

👉🏻 89% effective vs. hospitalisation

1/

nature.com/articles/s4159…
A few additional points…

Why is effectiveness vs hospitalisation lower than against all infection? This is the opposite of what we see in larger studies of the whole population, eg. this PHE data… 2/

media.tghn.org/articles/Effec…
Very few people were hospitalised (5/10,861 in the unvaccinated group compared to 0/10,861 in the vaccinated group).

This means the confidence interval for effectiveness vs hospitalisation was wide (43 - 100%) which is likely to have lowered the central estimate. 3/
Read 6 tweets
17 Aug
On holiday without much in the way of internet, but wow! My notifications blew up when I hit some WiFi this afternoon. A few points on this… 1/
First, I’m surprised neither of them checked our national guidance, which is set out in detail for medical professionals here… 2/

assets.publishing.service.gov.uk/government/upl…
Or the guidance from @RCObsGyn and @MidwivesRCM, which makes a clear recommendation that #pregnant people get the #COVID19 #vaccine. You can find it here… 3/

rcog.org.uk/en/guidelines-…
Read 7 tweets

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