[Thread] BREAKING 1. Real-world @Discovery_SA data on how well #Pfizer's two-dose #COVID19 jab works in SA:
14 days to 3 months after taking the 2nd shot: :
- 94% effectiveness @ COVID-related death
- 92% effectiveness @ COVID-related hospitalisation
14 days to 3 months after taking the 2nd shot: :
- 94% effectiveness @ COVID-related death
- 92% effectiveness @ COVID-related hospitalisation
2. What is real-world effectiveness?
It’s data from an actual vaccine roll-out. During studies jabs = used under tightly controlled conditions. In the real world those conditions = more fluid. Real-world data = how well jabs work outside of a trial.
It’s data from an actual vaccine roll-out. During studies jabs = used under tightly controlled conditions. In the real world those conditions = more fluid. Real-world data = how well jabs work outside of a trial.
3. Is there a difference between the protection offered by 1 dose of the #Pfizer jab and 2 doses?
Yes.
- 1 dose = 78% effective @ hospitalisation (28 days after you’ve had a jab)
- 2 doses = 94% effective @ hospitalisation (14 days after the 2nd jab)
Yes.
- 1 dose = 78% effective @ hospitalisation (28 days after you’ve had a jab)
- 2 doses = 94% effective @ hospitalisation (14 days after the 2nd jab)
4. How did @Discovery_SA collect + analyse data?
1. They used the same method scientists use to measure how well influenza jabs work.
2. It’s called a test-negative design study (comparing the vaccination status of people with +#COVID19 tests to those with -#COVID tests).
1. They used the same method scientists use to measure how well influenza jabs work.
2. It’s called a test-negative design study (comparing the vaccination status of people with +#COVID19 tests to those with -#COVID tests).
5. Where does @Discovery_SA’s data come from?
All the data is from Discovery Health medical aid members collected between 17 May (start of #VaccineRollOutSA) and 23 Sep.
They analysed:
- 526,516 #COVID19 tests
- 14,673 #COVID hospital admissions
- 3,441 COVID deaths
All the data is from Discovery Health medical aid members collected between 17 May (start of #VaccineRollOutSA) and 23 Sep.
They analysed:
- 526,516 #COVID19 tests
- 14,673 #COVID hospital admissions
- 3,441 COVID deaths
6. Does the sex of a fully vaccinated person influence how likely they are to get hospitalised because of #COVID19?
No. Vaccinated men and women (of 18+) are equally likely to get admitted (or not admitted) to hospital.
No. Vaccinated men and women (of 18+) are equally likely to get admitted (or not admitted) to hospital.
7. Do specific chronic conditions (comorbidities, e.g. #HIV, #diabetes) influence how likely a fully vaccinated person is to get hospitalised because of #COVID19?
No, but what does matter is how MANY chronic conditions a person has (see next tweet).
No, but what does matter is how MANY chronic conditions a person has (see next tweet).
8. Does the nr of chronic conditions (comorbidities) that a fully vaccinated person has influence how likely they are to get hospitalised?
Yes. People with 3 or more conditions are more likely to fall seriously ill with #COVID and be admitted to hospital.
Yes. People with 3 or more conditions are more likely to fall seriously ill with #COVID and be admitted to hospital.
9. How does AGE influence how likely a fully vaccinated person is to be hospitalised because of #COVID19?
People of 80+ are most likely to get admitted — but even for older people, the risk remains relatively low (protection = 88% for 80+ vs. 92-94% for all 18+).
People of 80+ are most likely to get admitted — but even for older people, the risk remains relatively low (protection = 88% for 80+ vs. 92-94% for all 18+).
10. Did the effectiveness of the #Pfizer jab wane over a period of 3 months (the data interval looked at)?
No. Studies that will look at waning immunity over longer periods of time in SA are being conducted.
No. Studies that will look at waning immunity over longer periods of time in SA are being conducted.
11. Do #Pfizer jabs give people who've had #COVID19 more protection than they'd have if they relied on natural immunity only?
YES.
If you’ve had COVID + fully vaccinated, your risk of hospitalisation = 98% reduced. If you rely on natural immunity only your risk = 85% reduced.
YES.
If you’ve had COVID + fully vaccinated, your risk of hospitalisation = 98% reduced. If you rely on natural immunity only your risk = 85% reduced.
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