JUST IN [Thread]: 1. @HealthZA disagrees with the US government's CDC's decision to recommend #mRNA jabs above #JnJ (because of rare side effects) - we'll continue using JnJ 2. The US = abundance of jabs (100 mil + ready for use), so they can afford 2 be choosy.
2. How safe is #JnJ? 1. @MRCza analysed safety data from the #Sisonke study (which uses #JnJ) 2. Serious side effects were rare and occurred in only 129 out of about 500 000 #HealthWorkers in the study
3. What does #Sisonke data tell us about mild #JnJ side effects? 1. The commonest side effects = headache, body aches, pain @ injection site, fever 2. Most side effects = occurred within 48 hours of vaccination
4. What does #Sisonke data say about serious side effects? 1. Among about 500,000 #HealthWorkers:
- 2 cases of thrombosis with thrombocytopenia/TTS (blood clotting)
- 4 cases of Guillain-Barre syndrome
- No deaths due 2 TTS /Guillain-Barre (What is it? mayocl.in/3Jg3zgd)
5. Will @HealthZA continue to use #JnJ?
Yes.
Why? They say: 1. There is no reason for widespread concern 2. Most side effects = minor and blood clotting = an extremely rare complication, affecting between 1 and 4 per million people who are vaccinated with JnJ
6. So what now? 1. @SAHPRA1 is working with the #Sisonke researchers to ensure appropriate precautions are taken 2. The #Sisonke 2 study = given 230, 000+ 2nd doses of #JnJ. So far: 2 doses of J&J = protective @ hospitalisation with efficacy data equivalent to other jabs
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It’s when health workers try to trace the people 1 infected person could potentially have infected by asking the infected person who they have been in contact with and getting those people to then test or isolate if they test positive.
In short: It’s too expensive for what we get out of it, so we spend a lot of money 4 very little gain (gain = picking up infected people + stopping them from infecting others). We could use the money better on other stuff/diseases.
BREAKING [Thread] 1. @SAHPRA1 has approved a 2nd dose of #JnJ and heterologous (mix/match) booster for adults:
1. If u had a JnJ jab, u can get a booster @ least 2 mnths after 1 JnJ shot 2. If u had a #Pfizer jab, u can get a JnJ booster @ least 6 mnths after a 2nd Pfizer jab
2. Does @SAHPRA1's approval mean you can have a #Pfizer booster after a #JnJ shot?
NO. It’s only the other way around (a #JnJ booster after a 2nd #Pfizer shot) that has been approved as a “mix and match” booster.
3. Why does @sahpra1’s “mix and match” approval not allow for a #Pfizer booster after a #JnJ shot?
Pfizer hasn’t submitted data to Sahpra for approval (#JnJ submitted the data 4 a #JnJ booster after #Pfizer).
[Thread] 1. NEW study on how sick (or not) #Omicron makes people in SA
Full study here: bit.ly/3mo2Y2c (preprint)
2. Cheryl Cohen @nicd_sa: 1. #Omicron emerged in SA when:
- 60-70% of people in SA had been previously infected (so they have natural immunity) 2. Early data suggest less severe disease during the Omicron period
3. #Omicron replaced Delta VERY fast in SA - in Gauteng, where SA's Omicron outbreak started, it replaced Delta within 2 weeks (so it spreads fast).
[Thread] 1. Where does #COVID19 test data in SA come from?
Adrian Puren, @nicd_sa: 1. From people with symptoms who get tested 2. From travelers 3. From both the public and private sector
2. All the #COVID19 testing data is then sent to the NICD and assembled in tables.
3. #COVID19 testing data can be found at these websites:
[Thread] 1. SA's #Omicron#COVID19 wave seems to have turned (cautiously optimistic view). @rid1tweets: 1. Much steeper wave than previous waves, but also much shorter 2. Half the nr of days to reach the Omicron peak vs. peaks of other waves
2. The 7 day moving average of new #COVID19 cases for #Omicron (at what seems/could be the peak of the wave) = 23 4237 vs.
- #Delta peak 19,956
- Beta peak 19,042
- D614G peak 12,584
3. Here are the 7-day moving averages of new #COVID19SA cases, hospitalisations and in-hospital #COVID deaths up until 19 Dec (via @CAPRISAOfficial, @nicd_sa and DATCOV):
- Hospital admissions and deaths, at this stage, still significantly lower than in previous waves.
1. Omicron = detected in 76+ countries 2. All SA's 9 provinces = in 4th wave, although NC is still technically entering its 4th wave (but that's according to a calculation formula, not in practice)
2. #JoePhaahla: 1. Although Gauteng = still highest nr of new #COVID19 cases, all 9 provinces in SA have seen a rapid rise in new cases 2. GP (where SA's #Omicron outbreak started): Thu = 27% of new #COVID19 cases vs. 7-10 days ago, GP cases accounted for 70-80% of new cases
3. #JoePhaahla:
The nr of 4th wave #COVID19 cases has exceeded the peaks of waves 1, 2 (Beta), 3 (#Delta)
By how much?
Wave 1: 21 new cases/100,00 people
Wave 2: 32 new cases/100,000 people
Wave 3: 33 new cases/100,000 people
Wave 4 (#Omicron): 37 new cases/100,000 people