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Feb 20 • 5 tweets • 3 min read
In the 2-year POUNDS lost weight-loss intervention trial, higher blood DNA methylation level at TXNIP was related to lower fasting glucose, HbA1c, and HOMA IR, and such individuals benefited more in improvements in glycemic control from an average-protein weight-loss diet.
- Higher regional DNA methylation level at TXNIP was associated with lower fasting glucose, HbA1c, and HOMA-IR among participants who were overweight or obese.
- Dietary protein intakes significantly modified the relation between regional DNA methylation level at TXNIP and changes in insulin and HOMA-IR at 6 months, independent of weight loss.
- Such effect modification became non-significant at 2 years.
Blood DNA methylation at TXNIP and glycemic changes in response to weight-loss diet interventions: the POUNDS lost trial

doi.org/10.1038/s41366…

#MetabolicSyndrome #InsulinResistance #nutrition #diet #weightloss ImageImage

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Feb 22
This systematic review and meta-analysis of RCTs comes to the conclusion that ~700 METs-min/week is the minimal dose to elicit clinically important changes in cognition in older adults.
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Feb 22
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- Worse still, even though the salivary caffeine nearly reaches a clear state, the caffeine-associated brain responses seem to require a longer time to be fully restored.
"The concurrence of a reduced hippocampal GM intensity and an incomplete caffeine elimination, together with a GM recovery after being deprived of caffeine, underscore the importance of a sufficient cessation period...
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Feb 22
This Mendelian randomization analysis suggests that VAT mass is associated with a wide range of CVD outcomes including coronary heart disease, cardiac arrhythmia, vascular diseases, and stroke, with some circulating proteins being potential mediators of this association. Image
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Feb 22
This systematic review and meta-analysis aimed to investigate the efficacy of increasing dietary protein ingestion to improve lean body mass gain, skeletal muscle strength, and physical function in healthy subjects.
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Feb 22
This study explored the effect of three different modes of resistance training on appetite hormones, cardiometabolic and anthropometric measures in males with obesity.
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Feb 22
This one suggests that individuals with high serum microRNA-122 levels may be less responsive during diet/physical activity-induced weight loss, as far as hepatic fat content loss is concerned.
- In the current study of participants with abdominal obesity or dyslipidemia from an 18-month randomized, controlled diet and physical activity intervention trial, it was observed that serum miR-122 levels were positively associated with hepatic fat percentage at baseline.
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