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Dr Sudhir Kumar MD DM🇮🇳

Oct 10 • 4 tweets • 2 min read

Commonly used drug for acidity #Ranitidine may increase the risk of #cancers

1. Ranitidine (sold under the brand name Rantac, zinetac, aciloc) is commonly used for treating acidity. Analysis of ranitidine samples has shown contamination by a chemical NDMA (nitrosodimethylamine)

2. Ranitidine use caused higher incidence of pharynx, oesophagus, stomach, liver, pancreas and colorectal cancers. Ref: Cancers (Basel), Jan 2021
3. USFDA banned ranitidine in April 2020. In India, it is not banned, but was removed from National list of essential medicines in Sep

Conclusion: It is better to avoid use of ranitidine for treating acidity due to a higher risk of gastro-intestinal cancers with its intake.
#MedTwitter #Acidity

Among proton pump inhibitors, omeprazole and esomeprazole have been shown to increase the risk of stomach cancers.

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Dr Sudhir Kumar MD DM🇮🇳

@hyderabaddoctor

Oct 12

Heart rate during work out: What is desirable and what is unsafe?
1. For an aerobic activity to be effective, the intensity should be at least moderate. The best way to measure the intensity of workout such as running is to check the #Heart rate. This thread is about heart rate.

2. What is resting HR?
Resting HR is the HR noted on waking up after a good night's #sleep before you leave the bed. For most adults, it ranges between 60-100/min. For physically #fit people, it may be lower, and may range between 40-60/minute.

3. Which is better- lower or higher resting HR?
Lower resting HR is better. It means- heart has to contract lesser number of times to do its work. Studies have found that a HIGHER resting heart rate is linked with LOWER physical #fitness, HIGHER blood pressure and body #weight.

Read 6 tweets

Dr Sudhir Kumar MD DM🇮🇳

@hyderabaddoctor

Oct 5

A beginner's guide to long-distance consistent running

I had no sports background & had never run before. Started #running 2 years back (6 Nov 20) at age 49. Ran 5454 km in 2021, and 3604 in 2022 until today. 9058 km in 643 days (Av 14.1 km/d). Includes 591 10k+ runs and 106 HM

Running resulted in several benefits- 22 kg #weightloss (95kg before to 73kg now). HbA1C: 4.8; normal cholesterol & BP, resting HR 45/min. Physically active and mostly pain-free despite having #ankylosingspondylitis Not on any medications.

I wish to answer some common queries, mostly based on my personal experiences (and some based on my medical knowledge)
1. Can everyone run long distances? Yes, if there is no significant medical illness, anyone can run. If you have a health issue, get clearance from your doctor.

Read 15 tweets

Dr Sudhir Kumar MD DM🇮🇳

@hyderabaddoctor

Oct 3

When is the best time to take BP-lowering medicines: morning or night?

High BP (#hypertension) is a common risk factor for causing #stroke, #heartattack, #heart failure and #death. Keeping BP within normal limits is one of best ways to prevent these complications.
#MedTwitter

In people without hypertension (HTN), BP is usually lower during nights (#sleep), however, in people with HTN and people aged 55 or more, BP can actually rise during sleep (reverse dipping). Studies have shown a higher incidence of heart attacks and strokes in early mornings.

In a large clinical research done in Spain in about 20,000 people, who were followed up for >6 years, people who take their BP medicines at night time had better 24-hour BP control, including at nights, as compared to those who take BP medicines in mornings.

Read 5 tweets

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