Though not its intention, this study from #OW2022 illustrated the concepts of satiation vs satiety very well
Colloquially we use these terms interchangeable
But they are technically different
#obesity #science #research #physiology #pathophysiology
#weight
1/
Colloquially we use these terms interchangeable
But they are technically different
#obesity #science #research #physiology #pathophysiology
#weight
1/
Satiation is the feeling of fullness WITHIN a meal while satiety is the feeling of fullness IN BETWEEN meals
Even though current meds like GLP1s seem to affect both, it’s an impt distinction especially when some peptides (eg, amylin)
Even though current meds like GLP1s seem to affect both, it’s an impt distinction especially when some peptides (eg, amylin)
may only effect satiation (⬇️meal size) and not satiety (change meal frequency)
[btw This study was an intracerebral injection of calcitonin into male rats and calcitonin is an agonist at the amylin receptor in the ventral tegmental area]
[btw This study was an intracerebral injection of calcitonin into male rats and calcitonin is an agonist at the amylin receptor in the ventral tegmental area]
Clinically, you’ve probably heard your pt say “I’m not hungry until I start eating and then it feels like I can’t stop”
👉 this is a problem with satiation, not satiety
👉 potential for different solutions especially as we phenotype #obesity and develop #precisionmedicine
👉 this is a problem with satiation, not satiety
👉 potential for different solutions especially as we phenotype #obesity and develop #precisionmedicine
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