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Dr Sudhir Kumar MD DM🇮🇳 Profile picture
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Dec 24 • 10 tweets • 2 min read
Older adults with greater muscle strength have lower risk of depression

1. Depression is common among older adults and its prevalence has increased over the past three decades. Depression increases the risk of suicides, stroke, heart attack, high BP and disability.
#psychtwitter
2. Preventive strategies, including increasing muscle strength can reduce the incidence of depression by 25%.
Handgrip strength is an easy-to-use, fast & reliable indicator of both sarcopenia (age-related loss of muscle mass) and dynapenia (age-related loss of muscle strength).
3. In a study comprising 1,15,601 adults aged 50 or more from 24 countries, with 7.3 years follow up, higher levels of handgrip strength were associated with lower risk of depression.
There was dose-response seen: Greater the hand grip strength, lesser was the risk of depression
4. Neurotrophins such as brain-derived neurotrophic factor and neurotrophin-3 are produced by skeletal muscle among other tissues, and are associated with mood improvements.
5. Sarcopenia (loss of muscle mass) is a risk factor for depression, and increasing muscle mass is an excellent method to reduce depression risk.
6. Loss of skeletal muscle is associated with high levels of inflammatory markers such as interleukin-6 and C-reactive protein.
Low grade inflammation (manifested by raised CRP) can be seen in about 25% of patients with depression.

Muscle strengthening can reduce inflammation.
7. Being physically strong leads to a sense of psychological well-being.
Being physically active, improves cognitive functioning and reduces the risk of neurodegeneration.
8. Those participating in exercise interventions with greater access to supportive social relationships have greater reductions in depression severity, compared with those with lower access.
9. Conclusions
*Muscle strengthening exercises reduce the risk of depression.
*Those with poor muscle mass or strength (as identified by poor hand grip strength) should be encouraged to start strength training.
10. Reference
doi.org/10.1192/bjp.20…

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Dr Sudhir Kumar MD DM🇮🇳 Profile picture
Dec 24
Case of a woman in whom “Runny Nose” was caused by a Brain Disease

1. 35-year-old woman presented with intermittent #runny #nose and #headache of one month duration.
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Dec 23
Low Blood Pressure (BP) is also a risk factor for ischemic stroke

1. High BP is a well-known risk factor for ischemic and hemorrhagic #stroke .
In a study, low BP was also shown to increase the risk of ischemic stroke.
doi.org/10.1210%2Fjc.2…

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Dec 23
Heavy #coffee consumption can increase the risk of death among people with severe #hypertension

1. In a recent study, drinking 2 or more cups of coffee per day increased the risk of death by 2 times in people with BP>160/100 mmHg.
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Dec 22
A #runner who would #swing his left arm more than the right
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Dec 22
Problematic #alcohol use is common among #physicians

1. Problematic alcohol use can adversely affect physicians’ health as well as their ability to provide excellent healthcare to their patients.
A meta-analysis was recently published on this topic.
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2. Problematic alcohol use included hazardous, potentially hazardous, risky, at-risk, harmful, problematic, or heavy drinking or alcohol use, as well as alcohol misuse, alcohol dependence, and alcohol use more than low-risk guidelines and alcohol use disorder.
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Dr Sudhir Kumar MD DM🇮🇳 Profile picture
Dec 21
Psychosocial #Stress increases the risk of #stroke

1. A longitudinal study (2007-2021) was conducted on 27,000 people from 32 countries belonging to various continents to assess the relation of self-reported stress and risk of various types of stroke
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3. This association was consistent for all stress domains, including work stress, home stress, and financial stress. The association was independent of socioeconomic status, occupation, and educational level & remained significant after adjustment for cardiovascular risk factors.
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