Older adults with greater muscle strength have lower risk of depression

1. Depression is common among older adults and its prevalence has increased over the past three decades. Depression increases the risk of suicides, stroke, heart attack, high BP and disability.
#psychtwitter
2. Preventive strategies, including increasing muscle strength can reduce the incidence of depression by 25%.
Handgrip strength is an easy-to-use, fast & reliable indicator of both sarcopenia (age-related loss of muscle mass) and dynapenia (age-related loss of muscle strength).
3. In a study comprising 1,15,601 adults aged 50 or more from 24 countries, with 7.3 years follow up, higher levels of handgrip strength were associated with lower risk of depression.
There was dose-response seen: Greater the hand grip strength, lesser was the risk of depression
4. Neurotrophins such as brain-derived neurotrophic factor and neurotrophin-3 are produced by skeletal muscle among other tissues, and are associated with mood improvements.
5. Sarcopenia (loss of muscle mass) is a risk factor for depression, and increasing muscle mass is an excellent method to reduce depression risk.
6. Loss of skeletal muscle is associated with high levels of inflammatory markers such as interleukin-6 and C-reactive protein.
Low grade inflammation (manifested by raised CRP) can be seen in about 25% of patients with depression.

Muscle strengthening can reduce inflammation.
7. Being physically strong leads to a sense of psychological well-being.
Being physically active, improves cognitive functioning and reduces the risk of neurodegeneration.
8. Those participating in exercise interventions with greater access to supportive social relationships have greater reductions in depression severity, compared with those with lower access.
9. Conclusions
*Muscle strengthening exercises reduce the risk of depression.
*Those with poor muscle mass or strength (as identified by poor hand grip strength) should be encouraged to start strength training.

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