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CORE IM

@COREIMpodcast

Dec 15, 2022

1/🚨New Episode🚨
The Lipid Panel Reimagined: #MindtheGap Segment

How do you interpret the #lipidpanel to help inform patients' risk for #cardiovascular disease? Do you use #ApoB? 🧐

🎧: link.chtbl.com/Lipids
Sponsor: go.amboss.com/CoreIM-E8

2/ Unfortunately, our patient is stuck in "bumper-to-bumper" #cholesterol traffic 🚗!

See traffic analogy to understand why ApoB can give us information that LDL-C may not:

#Mindblown! 🤯

3/ Overall, LOWER ⬇️ is better for both #LDL-C and #ApoB in terms of reducing #CV disease risk!

But #discordance between LDL-C vs. ApoB is actually quite common!

Take a look at the orange line to see how ApoB confers a higher CVD risk over time 👇

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CORE IM

@COREIMpodcast

Nov 15, 2022

1/ November 14th is #WorldDiabetesDay

Let’s look back at one of the most influential #RCTs for

how we given insulin in #T2DM?

the #RABBIT2 trial🐰🧵

#Insulin #MedTwitter

2/ The #RABBIT2 study looked at the (1) efficacy and (2) safety of basal-bolus vs. sliding-scale #insulin in non-critical inpatients🏥.

Basal-bolus regimens consisted of a combo of #Glargine (basal) and #Glulisine (mealtime).

The primary outcome was average glucose🍬.

3/ See below for a graphical depiction of how the study was performed👇:

Read 6 tweets

CORE IM

@COREIMpodcast

Nov 9, 2022

@Pan_Financial

1/ 🚨 #5Pearls on Alcohol-Associated Hepatitis 🚨

Why is it an immune response?

✔️Direct EtOH insult ➡️ inflammation

✔️Disruption of the gut barrier ➡️ bacteria & inflammatory cells go up portal vein ➡️ to hepatocytes

🎧 link.chtbl.com/AlcHep
Sponsor: @Pan_Financial

@etapper

2/ Now, What else may be going on & what imaging and labs would you send off for ddx for Alc Hep?

Listen to the episode to hear a powerful story from @etapper differentiating Alc hep and worsening #cirrhosis

3/ What interventions are most linked to improved mortality?

Alcohol cessation and nutrition!

Alcohol leads to⬇️absorption of proteins, carbs, and fats as well as impaired absorption of micronutrients = Alc Hep induces catabolic state

See some tips below for daily targets!

Read 4 tweets

CORE IM

@COREIMpodcast

Nov 3, 2022

1/ Today on #StatswithCoreIM, let’s talk about #bias

2/ Let’s get started with a question: What type of bias do you think is present in this example?

3/ The answer is Verification bias! Verification bias is present when:

✔️The reference standard (gold standard) is not used for all cases [= emoji] partial verification

✔️there is more than one reference standard 🟰 differential verification

Read 8 tweets

CORE IM

@COREIMpodcast

Oct 19, 2022

1/🚨New Episode🚨
Aspirin for Primary Prevention: #MindtheGap Segment

What do current ACC and USPSTF guidelines say about daily low-dose #aspirin for the primary prevention of #cardiovascular disease?

🎧: apple.co/3VPRCV4
Sponsor: bit.ly/TCChoZ

2/Throwback to medical school pathophysiology!

Remember how the #atherosclerotic process takes place in blood vessels? 🫀

Now, where does #aspirin exert its effect during this cascade? 🤔

3/What do the most recent #RCTs inform us about the use of aspirin for primary prevention ⁉️

ASCEND, ARRIVE, ASPREE!

#CoreIMJournalClub 📕

Read 6 tweets

CORE IM

@COREIMpodcast

Oct 11, 2022

1/ Welcome back to #ReadingRoom with Core IM!

Have you ever been confused about what contrast #protocol to order?! 💭

“Protocols” = which phase of contrast is best evaluate the structure you are trying to see 🔎

Keep an eye on the white contrast being injected in this 🧵

2/ What are some different contrast protocols?

Compare and contrast the different protocols below ⬇️ and think about which clinical situations we use them in

3/ Use this table to order the right study for the *right* pathology. There are many protocols with timings and combinations to best evaluate specific pathologies.

& don’t forget to check in with your radiology team when stuck and making a decision about which study to order!

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