Raj Rajnarayanan Profile picture
Feb 1, 2023 16 tweets 16 min read Read on X
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (#15DAYTRENDS):

44.6% XBB.1.5
17.2% BQ.1.1
3.7% BQ.1
2.9% XBB.1
1.7% BQ.1.1.4
1.2% BQ.1.2
1.2% BQ.1.3
1.1% BQ.1.1.18

Tracker: tinyurl.com/mryj4uu7
Updated: 01/31/2023

1/n Image
Sequence count by US State

#NorthCarolina, #NewYork, #California and #Washington have submitted a big share of sequences

XBB.1.5 stays strong at the top spot and is establishing a clear foot print outside NE USA!

2/n Image
USA Airport surveillance update #15DayTrends

97 sequences from 6 US States (#California, #NewYork, #Washington, #NewJersey, #Georgia and #Virginia)

3/n Image
Granular details -#VariantDashboard #USA #15DayTrends

XBB.1.5 is surging ahead, leaving the rest of the swarm behind!

4/n Image
.@CDCgov updated variant proportions estimates on 01/27/2023 (updated every Friday)

CH.1.1 makes an entry @ 1.5% in the CDC Variant Dashboard

XBB.1.5 is leading at the top!



5/n
Top circulating #SARSCOV2 lineages around the world 01/11 to 01/31/23 (#20DayTrends):

BQ.1.1 (18.4%)
XBB.1.5 (13.5%)
CH.1.1 (6.1%)
BQ.1 (3.7%)
XBF (2.4%)
XBB.1 (2.3%)
BA.5.2.48 (2.3%)
BF.7 (2.0%)
BQ.1.9 (1.9%)
CH.1.1.1 (1.7%)
BQ.1.1.20 (1.3%)
BQ.1.1.13 (1.2%)

6/n
Predicted Immune Escape and ACE2 binding of top lineages in USA (relative to BA.2)

Bivalent boosters (OG/Omicron.BA.5) will potentially protect the boosted from getting severe disease/hospitalizations.

Please get #boosted ASAP!

public.tableau.com/app/profile/ra…

7/n
#Hospital #Capacity - (by State/Division)

All hospitalizations not just COVID-19

public.tableau.com/app/profile/ra…

8/n
#COVID19 #Hospitalizations in the #UnitedStates

Please get #boosted (especially > 50 yr old and immune compromised) and #MaskUP!

Hospital Tracker (by States, by age group): public.tableau.com/app/profile/ra…

9/n
Status of the latest #COVID19 Wave in #NewYork

XBB.1.5 is still the top circulating lineage in NY

10/n ImageImage
Circulating recombinant lineages - USA #15DayTrends

XBB.1.5 is still the top recombinant in circulation!

11/n ImageImage
Tracking circulating #SARSCoV2 lineages, Cases, #COVID19 #hospitalizations 👀 in #California

XBB.1.5 is the top circulating lineage in CA

Top circulating lineages

XBB.1.5 (30.6%)👀
BQ.1.1 (15.7%)
BQ.1 (4.2%)
BQ.1.1.32 (4.2%)
BQ.1.28 (2.8%)
BQ.1.25.1 (2.3%)
XBB (2.3%)

12/n ImageImage
Weekly Trends in Number of COVID-19 Deaths and Weekly Case Rate in The United States Reported to CDC, per 100,000 population.

covid.cdc.gov/covid-data-tra…

13/n Image
Tracking circulating #SARSCoV2 lineages, Cases, #COVID19 #hospitalizations 👀 in #Arizona

Only 5 sequences with sample collection dates in the last 15 days (1 XBB.1.5 & 4 BQ.1.1*)

14/n Image
Tracking circulating #SARSCoV2 lineages, Cases, #COVID19 #hospitalizations in #Texas

XBB.1.5 is the top circulating lineage in TX

Top circulating lineages

XBB.1.5 (34.3%)👀
BQ.1.1 (20.6%)
XBB.1 (12.3%)

15/n ImageImage
Tracking circulating #SARSCoV2 lineages, Cases, #COVID19 #hospitalizations in #NorthCarolina

XBB.1.5 is the top circulating lineage in NC

Top circulating lineages

XBB.1.5 (41.1%)👀
BQ.1.1 (20.0%)
BQ.1 (6.3%)
XBB.1 (3.7%)

16/n ImageImage

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More from @RajlabN

Jan 1
#H5N1 #AvianInfluenza updates

New @NEJM case report describing severe human illness caused by highly pathogenic avian influenza A -H5N1 in #BritishColumbia (#Canada) teenager with evidence of potential viral adaptation to humans.



1/n nejm.org/doi/full/10.10…Image
A 13-year-old girl with mild asthma and obesity (BMI >35) presented with conjunctivitis, fever, respiratory distress, and multi-organ complications was hospitalized on 11/7/24, and required intensive care, including ECMO and continuous renal therapy

2/n
RT-PCR confirmed A/H5N1 infection, and the virus was linked to wild birds in British Columbia.

Genetic analysis revealed mutations in the HA protein (E186D, Q222H), associated with increased binding to human airway receptors, facilitating viral entry and replication.

3/n
Read 6 tweets
Dec 22, 2024
#H5N1 #AvianInfluenza updates

Quick analysis of the 7 sequences from NIAID experimental study of #Macaques infected w/ H5N1 2.3.4.4b (B3.13 type)

PB2 mutations: T58A, V109I, V139I, E362G, K389R, D441N, V478I, V495I, M631L, V649I, M676A, E677K

Ref: A/Duck/Guangdong/E1/2012

1/n
HA mutations: L120M, L131Q, T211I, V226A, I526V

Ref: A/Astrakhan/3212_cell/2020

2/n
NA mutations: V67I, D259E, L269M, V321I, S339P

Ref: A/AmericanWigeon/SouthCarolina/22-000345-001/2021

3/n
Read 4 tweets
Oct 20, 2024
Tracking #SARSCoV2 #Lineages - Globally |10/19/24

Top lineages -#30DayTrends #G30

KP.3.1.1 (41.9%)
XEC (10.5%)👀
KP.2.3 (3.1%)
MC.13 (3.1%)
MC.16 (2.6%)
MC.1 (2.5%)
KP.3.3 (2.3%)
LB.1.3.1 (1.9%)
MC.10 (1.7%)
MC.11 (1.4%)
XEC.2 (1.3%)👀



1/n public.tableau.com/app/profile/ra…Image
Granular details #Global #30DayTrends

KP.3.1.1* is still the top circulating group of lineages in the world.

This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 09/19/2024 (11,851sequences)

2/n Image
@GISAID Thanks to all the countries that are supporting #SARSCoV2 testing and rapidly submitting sequences to @GISAID

Top submitters #Canada #USA #France #UK #Netherlands #Sweden #Spain #Japan #Italy
#Denmark #Australia #Ireland #Singapore
#China #NewZealand #Slovenia #Germany

3/n Image
Read 4 tweets
Sep 27, 2024
#SARSCoV2 #VariantProportions - #USA |09/27/24

@CDCgov #Nowcast 2-Week estimates

KP.3.1.1 (JN.1.11.1.3.1.1) is still the top circulating lineage in the USA

🚨XEC makes an entry @ 5.7%



1/n covid.cdc.gov/covid-data-tra…
Image
Reliable nowcast estimates are available only for HHS regions 2, 3, 4, 5, 7 and 9

Other regions did not sequence enough

2/n Image
KP.3.1.1* group of lineages

In the @CDCgov nowcast chart....
KP.3.1.1* is not further separated in to MC.1-MC.16 sub-lineages

3/n Image
Read 6 tweets
Sep 8, 2024
Tracking #SARSCoV2 #Lineages - Globally |09/07/24

Top lineages -#30DayTrends

KP.3.1.1 (37.1%)
KP.2.3 (9%)
KP.3.3 (5.7%)
KP.3.1 (2.9%)
XDV.1 (2.9%)
KP.1.1.3 (2.7%)
LB.1 (2.3%)
LB.1.3 (2.1%)
KP.2.2 (2%)
---
XEC (1.4%)👀

Track #G30 :

1/n public.tableau.com/app/profile/ra…
Image
Granular details #Global #30DayTrends

KP.3.1.1* is still the top circulating group of lineages in the world.

This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 08/08/2024 (12,884 sequences)

2/n Image
@GISAID Thanks to all the countries that are supporting #SARSCoV2 testing and rapidly submitting sequences to @GISAID

Top submitters #USA #Canada #UK #Sweden #Japan
#China #Spain #Australia #Germany #Denmark #SouthKorea #France #Singapore #NewZealand #Ireland #Italy #Netherlands Image
Read 16 tweets
Sep 1, 2024
What the XEC!

Recombinant #SARSCoV2 lineage #XEC (recombinant of KS.1.1/KP.3.3) has the potential to outcompete other circulating lineages in #USA (and other countries)

More data is needed to provide a reliable growth advantage estimates
Image
#VariantHunters are closely monitoring XEC.1 with signature mutations Spike K182R & ORF1a:L4182F
XEC.1 was proposed by #VariantHunter @siamosolocani

github.com/sars-cov-2-var…
Read 5 tweets

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