2 meses ♂️, madre VIH+, toxicómana, y chancro perineal indoloro en 2º trimestre del embarazo:
Un mes de rinorrea serosanguinolenta, lesiones dérmicas, FC 180lpm, FR 50rpm, Tª 38,8°C, crepitantes finos en tórax, hepatoesplenomegalia, 1/5
@_jicastillo@samanthap78 La sífilis está causada por Treponema pallidum, una bacteria espiroqueta.
La transmisión vertical puede conducir a una infección congénita del feto en mujeres embarazadas que reciben un tratamiento inadecuado o no reciben ningún tratamiento. 4/5
@_jicastillo@samanthap78 La sífilis congénita causa diversas manifestaciones clínicas que incluyen muerte neonatal, manifestaciones cutáneas y viscerales o infección asintomática. 5/5
A 26-YO♂️ no #sexual contacts other than with his male partner: 6-day of fever, malaise, a swollen parotid gland, & ulcerative lesion on the ipsilateral lower lip.
PCRs on the throat & ulcer swabs:➕for human #monkeypox (hMPX)
Genomic sequencing: clade IIb variant clustering within the current international mpox virus outbreak
Emergence of extensively drug-resistant (XDR) and multidrug-resistant (MDR) #Shigella flexneri serotype 2a associated with #sexual transmission among men who have sex with men (MSM), in #England: a descriptive epidemiological study 1/6 👇 thelancet.com/journals/lanin…
In this study, authors report the emergence and sustained transmission of #XDR and #MDR strains of S flexneri among among MSM, harbouring plasmid-encoded blaCTX-M-27, in England since September, 2021.
There were clinically severe cases, including hospitalisations.
2/6
Comparison to the XDR S. sonnei outbreak revealed epidemiological and #plasmid similarities and provided support for horizontal acquisition events in a community transmitting infection.
3/6
A 71-YO therapy for multiple mieloma, voriconazole for Aspergillus fumigatus sinusitis, prophylaxis with TMP-SMX: febrile neutropenia, nodular lesion on abdominal wall
CT: pulmonary nodule unchanged in last a month
🔬biopsy of pulmonary nodule? 1/8
🔬: Histiocytic process with granular basophilic cytoplasm and Michaelis-Gutmann bodies (arrows), positive for calcium with von Kossa special stain (arrowhead); findings pathognomonic for malakoplakia.
🧫of the pulmonary nodule:➖
🧫biopsy of the abdominal wall lesion: Rhodococcus equi resistant to TMP-SMX, but susceptible to rifampicin, vancomycin, azithromycin, ciprofloxacin, & imipenem.
RHODOCOCCUS EQUI SUBCUTANEOUS ABSCESS 3/8
A 50-YO ♀️ bitten by her pet rat: fever, myalgia, sore throat, headaches a nonpruritic rash on extremities including palms & soles, arthralgias, knees arthritis.
A punctate wound with central necrosis on L palm, & her R thumb. 1/9