Research suggests that these changes in cognitive function (#brain fog, poor memory, mood, and focus) may be accompanied by dysfunction in #brain energy metabolism that can be treated with #metabolic therapies. (1/17)
Cognitive dysfunction can arise when the brain's energy supply is disrupted. It's called brain hypometabolism. (2/17)
Head traumas and concussions in sports or accidents are associated with such changes and can cause behavioral changes and memory loss in adults. But you don't need a history of head injury for cognitive decline to occur. (3/17)
Abnormalities in brain energy metabolism appear as we age, which can be exacerbated in neurodegenerative disorders like Alzheimer's disease (AD). Brain glucose uptake is significantly reduced in #AD, contributing to cognitive impairment. (4/17)
I need you to understand this neurodegenerative process begins a good 20-30 years before you receive such a diagnosis. So you will want to deal with these symptoms now, as opposed to later. (5/17)
In 2022, an estimated 6.5 million Americans aged 65 and older are living with AD, and 73% are above age 75. AD is a slow progressive disease resulting in the death of neurons. (6/17) #alzheimers#AD
One potential strategy to reduce cognitive decline in aging and dementia is to increase blood ketone levels and enhance ketone uptake to the brain using a ketogenic medium-chain triglyceride (kMCT) drink. (7/17) #ketones
Supplementation with kMCT is believed to rescue brain energy dysfunction because brain glucose hypometabolism is present in early or late onset of AD. (8/17)
Research has shown that the brain's ability to take up ketones remains relatively unchanged despite the decrease #glucose uptake. (9/17)
This means that supplementing with ketones, such as through a ketogenic medium-chain triglyceride (kMCT) drink, may provide an alternative source of energy for the brain and potentially improve cognitive function. (10/17)
In a six-month study, 83 participants with a self-identified memory complaint and objectively categorized cognitive impairment were placed into two groups: 1) placebo (n = 44); and 2) kMCT (n = 39). (11/17)
Improved cognitive outcomes were significantly correlated with increased plasma ketone levels and increased ketone uptake by the brain. Read it here: ncbi.nlm.nih.gov/pmc/articles/P… (12/17)
When I was fixing my own brain, I tried #MCT oil without a consistent ketogenic diet, and I did not get improvement. I am APOE3/4, and there are some diffs in how 4's utilize MCT oils. They are found to be possibly less effective. (13/17)
Luckily, I didn't let that discourage me! I kept going and figuring it out. Eventually, I figured out how to make consistent ketones and the right ratios. And then I was up and running. (14/17) #gameon#levelup
So if you are trying MCT for yourself or a loved one, and are not seeing improvements, don't lose hope. You might just be one of those people who need the ketogenic diet! (15/17)
And there are lots of variations of ketogenic diets that can be helpful with this population, including classic, Modified #Atkins, and even an MCT-Oil #Ketogenic diet. (16/17)
It's important that you get to learn all the ways you (or a loved one) can feel better. And for many, MCT oil is one of them. (17/17) #ketones#MCT
• • •
Missing some Tweet in this thread? You can try to
force a refresh
Today we are going to talk about white matter disease and what it means for the brain. Settle in for a thread. 🧵(1/27)
The brain is mostly made up of gray matter and white matter. The gray matter covers the outside of our brain, which is called the cortex, meaning the bark. White matter is mostly on the inside. (2/27)
White matter consists of nerve fibers that connect different parts of the brain, and it's covered in a myelin sheath. This protective sheath appears white because it's made up exclusively of fat, along with a few other types of molecules. (3/27)
Doesn't butyrate also convert into beta-hydroxybutyrate in the main ketone body? Is there some inner conversion in the gut? Are these used interchangeably? (1/11)
For the most part, the pools of butyrate in the gut and beta-hydroxybutyrate (BHB) are separate. Remember, #BHB is a #ketone body that is produced by your body on a #ketogenic diet. (2/11)
There are some bacteria that may be able to put the hydroxyl group onto butyrate to create BHB. But for the most part, butyrate produced in the gut is mostly from the fermentation of fibers and different prebiotics. (3/11)
Diet influences gut microbiota composition, and several studies have investigated these effects. 🧵(1/15)
Weight loss induced by a very low carbohydrate ketogenic diet (VLCKD) has been shown to lead to a reduction in the abundance of the gut microbiota Cryptobacterium and Roseobacter, while increasing the abundance of Ristensenaceae and Akkermansiae. (2/15)
Studies have also investigated the impact of a high-fat ketogenic diet on gut microbiota composition. (3/15)
The mechanisms involved in the anti-inflammatory properties of the #KetogenicDiet remain largely understudied. But we know they are there, and we know they are based at least somewhat on brain immunology. Here is a bit of what we do know. 🧵(1/5)
"glucose metabolism within macrophages and microglia may play a role in KD’s anti-inflammatory effects via regulation of the pro-inflammatory transcriptional activity of the transcription factor Nuclear Factor Kappa B (NFKB). (2/5)
In addition, BHB (a ketone body) is able to mitigate activation-related microglial changes, such as microglial ramification. (3/5)