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Dave Feldman Profile picture
@realDaveFeldman
Apr 14 • 4 tweets • 4 min read Twitter logo Read on Twitter
1/ Chat on Triglyceride rich #LDL

#Me: Why would triglyceride rich LDL particles be more atherogenic than triglyceride poor LDL particles?

#ChatGPT: Triglyceride-rich LDL (low-density lipoprotein) particles are more atherogenic (i.e., more likely to contribute to the… twitter.com/i/web/status/1…
2/

#Me: Couldn’t it also be possible that triglyceride rich LDL are ultimately the result of metabolic dysfunction and that better explains its association with atherosclerosis?

#ChatGPT: Yes, that is also a possibility. Triglyceride-rich LDL particles are often associated… twitter.com/i/web/status/1…
3/

#Me: Is it possible that almost the entire amount of atherogenesis associated with high triglyceride rich LDL is due to dysfunctional lipid metabolism and the diseases that result in these profiles rather than the LDL particles themselves?

#ChatGPT: Yes, it is possible that… twitter.com/i/web/status/1…
4/
#Me: Given LMHRs have high LDL cholesterol, yet low triglycerides, suggesting a low quantity of triglyceride rich LDL, would they make an excellent study population to test this hypothesis of capturing their plaque progression with longitudinal CT Angiography?

#ChatGPT: Yes,… twitter.com/i/web/status/1…

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More from @realDaveFeldman

Dave Feldman Profile picture
Apr 13
1/🧵 I'm definitely a fan of both @DominicDAgosti2 and @DrRagnar (obviously), so I was excited to see them chatting about #lipids, #LMHRs, and Dom's consideration of increasing carbs to lower his #ApoB

If no one minds, I'd like to add some thoughts...

2/ First -- I'm extremely excited to share @DominicDAgosti2 may be the most notable N=1 I've waited for regarding #ResistanceTraining change & #LDL/#ApoB in a #ketogenetic context

Those who've followed me for a while know exactly what I'm talking about...
3/ When chatting with Dom in SD last year for dinner, he mentioned focusing less on maintaining such a sizable muscle mass as he typically does, and I predicted he'd likely see his LDL/ApoB as considerably higher with this change if still #keto. This podcast appears to confirm...
Read 10 tweets
Dave Feldman Profile picture
Mar 24
🧵Followup on #salt comment last night:

Took 3 readings of my blood pressure this morning:
113/78
106/68
98/74
Average: 106/73

Context:
- Male, 49
- Moderate exercise
- Moderate-high stress career
- Supp 6-10g of salt daily when #keto* to relieve fatigue, cramping (for >5 yrs)
2/ So everyone on #keto should be like me and take copious amounts of #salt?

Well, sorry, but the answer appears to be:
👉 Your results may vary.... a lot.

On the little-to-no salt side, check out @KetoCarnivore's recent discussion on this
3/ Also check out this short video answer in a Q&A from Steve Phinney regarding salt intake research
Read 5 tweets
Dave Feldman Profile picture
Mar 23
1/ #Metabolism, #lipids, and #ASCVD
#megathread🧵🧵🧵

Okay, I want to revisit and breakdown my position on this crucial topic and the challenges in communicating it.

⚠️ Get comfortable, as this could get long.

Ready? Let's go...
2/ First, it's worth reviewing why there's a high level of confidence low density lipoproteins (LDLs) drive atherosclerotic cardiovascular disease (ASCVD)

For an excellent, lay-person video, I recommend @NutritionMadeS3's from a couple years ago 👇

3/ Also in the name of arguably the most cited meta-analysis for the Lipid Hypothesis to date:

"Low-density Lipoproteins cause atherosclerotic cardiovascular disease"

This meta combines lines from genetic, observational, and interventional studies.

pubmed.ncbi.nlm.nih.gov/28444290/
Read 25 tweets
Dave Feldman Profile picture
Mar 12
Maybe. I hope so.

Let me just say a major problem with the #diet and #nutrition space is just how many sides seek to oversimplify these things.

And as unpopular as it is to say it, I think there's way too much focus of folks having extremely quick success as though it's common.
I know it's well intentioned.

But I also know many people in my own family who have struggled their whole lives to lose weight and assume if they don't have this near instant drop to their goal weight like <fill in the blank success story> then they are doing it all wrong...
... I can't tell you how many times I point out truly new, record-setting successes with people I know personally -- but it's their own record, their own health journey.

But they often can't see it because they hear they "won't be hungry anymore on <fill in blank diet>"...
Read 5 tweets
Dave Feldman Profile picture
Mar 11
1/ My thoughts on #Satiety & @DietDoctor 🧵

If you've followed me a while, you know I try to avoid the "diet debates" (tho not always successfully)

However, I have been getting a high frequency of DMs/messages/calls regarding DD's new endeavor for a #lowcarb alternative
2/ Let me first start off by saying I don't think any diet is inherently superior to all others.

I *do* think the #lowcarb diet is under-utilized for populations that can uniquely benefit from it.

However, I also believe most of us have many more options than is often assumed.
3/ Moreover, I consider @DietDoctor's long history of providing a "one stop shop" platform for all things #lowcarb/#keto with high quality guides, videos, and tools to be without equal.

It made it extremely easy to refer everyone in DD's direction, particularly beginners.
Read 16 tweets
Dave Feldman Profile picture
Mar 9
1/ Yes-- I've been meaning to literally do an entire talk on Simpson's Paradox because the concept is really quite simple.

Here's an example:
✅Hypothesis: higher body weight causes higher blood pressure.

💡If we only had scales and BP cuffs, we'd certainly see the relationship
2/ Let's further point out we could demonstrate it over three lines of evidence: observational (epi), interventional (Rx), and genetic (🧬)

Epi: When randomly grabbing a large population of Americans, we find those who generally weigh more generally have higher BP ✅
3/ Rx -- interventions that generally reduce weight, also generally reduce BP ✅

And lastly, 🧬 -- most genes that associate with lower weight will generally have lower BP ✅

Now obviously we have more advanced tools these days than weight scales and BP cuffs...
Read 7 tweets

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