Miscalibrations Profile picture
Jun 5 β€’ 4 tweets β€’ 5 min read Twitter logo Read on Twitter
πŸ’Š Older adults make up 56% of the global cancer population, yet they're just 40% of participants in new cancer therapy trials. The underrepresentation of this key demographic in clinical trials is a major concern. #clinicaltrials #healthcare #aging Image
πŸ’ŠTrials biased towards younger patients without comorbidities and multiple prescription drugs yield cleaner datasets but may not provide sufficient evidence on drug safety and efficacy for older populations. 2/3
#ClinicalTrials #aging #healthcare Image
πŸ’Š US and UK regulators recognize the problem and have issued guidelines to address it recently. While guidelines and incentives can make a difference, legislation may be necessary to fully tackle the problem in the end. βš–οΈ 3/3
#ClinicalTrials #aging #healthcare #FDA Image
πŸ’Š Later, I'll write a thread about the importance of gender balance in preclinical animal studies and clinical trials. I'll also discuss how anti-aging treatments can yield different results in animals based on sex. 🐭#ClinicalTrials #healthcare #aging
sciencedirect.com/science/articl… Image

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More from @DavidsAlienHerb

Jun 7
1/ "Fits at Chess" might seem like a punchline, but it's a real health concern 🧠. I've been exploring research papers on the negative effects of #Chess on well-being, societies, and ecosystems, and found the first report of chess triggering #epilepsy from 1965. #NorwayChess Image
2/ These cases fall into a category of reflex #epilepsy - seizures are activated by specific, identifiable triggers. Such triggers can be external (flashing lights, hot water 🚿), internal (emotions, thought πŸ’­), or a mix of both.
#chess #NorwayChess #neuroscience #brain Image
3/ Among reflex #epilepsies, the most common are those triggered by visual stimuli or light changes (1 in 4,000). Much rarer triggers include eating 🍎, music 🎡(1:10 M), writing ✍️, orgasm πŸ’‹ and even lying. #Chess, other #boardgames, and #cards can also trigger seizures. Image
Read 10 tweets
Jun 5
1/4 Here we go! Chess eats your 🧠 gray matter!
"Grey matter volume and cortical thickness were reduced in chess players compared with those of control men in the occipitotemporal junction and precunei." #Chess #chesspunks #NorwayChess Image
2/4 Chess is a silent "killer" of 🧠 cortex locally.

πŸ’‘Who holds the record for the thinnest 🧠 cortex among chess players in history? Will collective chess 🧠 solve this mystery despite the thinning? Retweet! πŸ”
#Chess #chesspunks #brain #neuroscience #NorwayChess ImageImage
3/4 🧩 Stay tuned for more revelations from a treasure trove of almost 1000 scientific papers exploring the mental and other challenges of chess players. As a chess player myself, I hope for 1 or 2 papers highlighting the benefits of the game. #Chess #chesspunks #NorwayChess πŸ” Image
Read 4 tweets
Jun 5
πŸ“’ Google provides a shortfree introductory course on Large Language Models (LLM), the technology beyond ChatGPT, Bard, and Bing search. I highly recommend it to anyone. What is covered?
#AI #ArtificialIntelligence #courses 3/3 πŸš€
cloudskillsboost.google/course_templat… Image
Course objectives:
πŸš€ Define Large Language Models (LLMs)
πŸš€ Describe LLM Use Cases
πŸš€ Explain Prompt Tuning
πŸš€ Describe Google’s Gen AI Development tools
#AI #ArtificialIntelligence #courses 2/3
It only takes an hour to get the fundamental concepts! πŸ•. Afterward, check out an insightful presentation from OpenAI, a competitor of Google, on the training and application of LLMs. #AI #ArtificialIntelligence #ChatGPT 3/3 πŸ§ πŸš€
Read 4 tweets

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