Lumos Biotech Profile picture
Biotech, viruses and new medicine (research only, no advice)
Apr 15, 2020 โ€ข 12 tweets โ€ข 11 min read
THREAD from the new #bradykinin research (pre-print) from ๐Ÿ‡ณ๐Ÿ‡ฑ:

"We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on #endothelial cells in the lungs."

#COVID19 #kininsโ€ฆ โžก๏ธ"the B1 receptor on endothelial cells is upregulated by proinflammatory #cytokines

โžก๏ธ Without #ACE2 acting as a guardian to inactivate the ligands of B1, the lung environment is prone for local vascular leakage leading to #angioedema"


#bradykinin #COVID19
Feb 27, 2020 โ€ข 4 tweets โ€ข 4 min read
After extensive reading on #Chloroquine via ๐Ÿ‡ซ๐Ÿ‡ท media ce soir, still seeing ๐Ÿ’Š potential vs #COVID19.

Today ๐Ÿ‡ซ๐Ÿ‡ท Health Min stated that it's not verified externally for clinical use. But Didier Raoult of @IHU_Marseille is adamant of its potential.

What do you think? Links ๐Ÿ‘‡ <๐Ÿ‡ซ๐Ÿ‡ท FR 1 >โ€ฆ

<๐Ÿ‡ซ๐Ÿ‡ท FR 2 >โ€ฆ
Feb 23, 2020 โ€ข 11 tweets โ€ข 12 min read
#COVID19 #CoronaVirus

๐Ÿ‡ฎ๐Ÿ‡น#Italia Superspreader #Cluster THREAD 1/7๐Ÿจ

Drew a #dataviz diagram based on available data* about the #Lombardy cluster, which as of EOD 2/22/20 had 54 cases, including 2 in #Milano, & still an unknown Patient 0.

*plz excuse any possible errors 2/7 This cluster has developed quite rapidly in the town of #Lodi, near #Milan, in the #Lombardy region of #Italy.

The story has shifted several times on Patient 0, but somehow Patient 1 - a 38 y/o male in Lodi - contracted the #COVID19 virus.

When Patient 1 had symptoms...