THREAD from the new #bradykinin research (pre-print) from 🇳🇱:

"We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on #endothelial cells in the lungs."

#COVID19 #kinins

preprints.org/manuscript/202… ➡️"the B1 receptor on endothelial cells is upregulated by proinflammatory #cytokines

➡️ Without #ACE2 acting as a guardian to inactivate the ligands of B1, the lung environment is prone for local vascular leakage leading to #angioedema"

...

#bradykinin #COVID19

After extensive reading on #Chloroquine via 🇫🇷 media ce soir, still seeing 💊 potential vs #COVID19.

Today 🇫🇷 Health Min stated that it's not verified externally for clinical use. But Didier Raoult of @IHU_Marseille is adamant of its potential.

What do you think? Links 👇 <🇫🇷 FR 1 > nicematin.com/sante/ce-trait…

<🇫🇷 FR 2 > 20minutes.fr/sante/2727411-…

#COVID19 #CoronaVirus

🇮🇹#Italia Superspreader #Cluster THREAD 1/7🏨

Drew a #dataviz diagram based on available data* about the #Lombardy cluster, which as of EOD 2/22/20 had 54 cases, including 2 in #Milano, & still an unknown Patient 0.

*plz excuse any possible errors 2/7 This cluster has developed quite rapidly in the town of #Lodi, near #Milan, in the #Lombardy region of #Italy.

The story has shifted several times on Patient 0, but somehow Patient 1 - a 38 y/o male in Lodi - contracted the #COVID19 virus.

When Patient 1 had symptoms...