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https://twitter.com/gabegutierrez/status/1430515300001255424An exponential fight requires exponential weapons that control the transmission driving exponential growth: vaccines for all eligible, universal masking, TTI, ventilation, etc. This makes it possible for treatment capacity to keep up with demand. 2/
https://twitter.com/HelenBranswell/status/1390274848392368133Scaling up vaccine manufacturing is *far* more complex than HIV medicines or other drugs. And the safety and benefit/risk calculation is completely different because vaccines are given to healthy people including children. 2/
https://twitter.com/rvenkayya/status/1356286204745015296?s=20
https://twitter.com/rvenkayya/status/1367544912217075716?s=20Direct protection from vaccines (protection of the vaccinated person) goes a long way toward limiting illness and death, but indirect protection massively amplifies the impact. Here’s a good explainer from @ZoeMcLaren. 2/
https://twitter.com/ZoeMcLaren/status/1373722257957195777?s=20
https://twitter.com/EricTopol/status/1367487223092760576?s=20This thread describes a world in which vaccines reduce transmission. Early evidence is promising, although more data is needed to understand magnitude of reduction and differences between vaccines. 2/
https://twitter.com/rvenkayya/status/1356286201309900800?s=20
https://twitter.com/PeterHotez/status/1358752684841525250?s=20
https://twitter.com/rvenkayya/status/1320022543076630529?s=20Much of the risk is in "scaling up" production to produce large volumes of vaccine in a facility, and “scaling out” to manufacturing partners to expand capacity. This thread is about vaccine manufacturing and the challenges we’ll continue to face. 2/
https://twitter.com/rvenkayya/status/1346815419810799617?s=20
https://twitter.com/rvenkayya/status/1343621750492377089?s=20Multiple lines of evidence strongly suggest mutations in B.1.351 confer some escape from natural and vaccine immunity.
https://twitter.com/K_G_Andersen/status/1355005699999158276?s=20
https://twitter.com/Bob_Wachter/status/1345741327330263042?s=20I based this on recent statements from the UK chief medical officers, JCVI, and what we know from prior vaccine development. 2/
https://twitter.com/HelenBranswell/status/1344306446910058496?s=20UK’s MHRA and JCVI are highly-experienced in vaccine assessments and recommendations, and they've surely weighed the benefits & risks of this recommendation carefully. That said, it would be good to see all the data underpinning their recommendation. 2/
https://twitter.com/notdred/status/1344248984571936768?s=20
https://twitter.com/kakape/status/1342063459350020097The first indication of whether vaccine protection is affected will come from the lab: neutralization studies assessing whether vaccine-induced antibodies are as effective at neutralizing the new variant as earlier strains of SARS-CoV-2. Similar activity will be reassuring. 2/
https://twitter.com/bhrenton/status/1335306082693083137?s=20
https://twitter.com/notdred/status/1333555525880049664It is not a simple undertaking to establish a human challenge model, particularly with a novel virus for which the pathophysiology is not well-understood and where a targeted therapeutic is not available for what could be a lethal disease. 2/
https://twitter.com/CNNSotu/status/1330521936221392902?s=20@bnallamo @US_FDA An EUA (Emergency Use Authorization) for a vaccine is not the same as a therapeutic, given that the vaccine is being given to subgroups of people who are “healthy” and may or may not be exposed to the virus. The bar for safety & efficacy data is therefore higher than for Rx. 2/
https://twitter.com/rvenkayya/status/1325850822677303297?s=20First let’s break this down into three questions:
https://twitter.com/ashishkjha/status/1325770292199907330First, it shows vaccines *can* prevent COVID illness in humans, and it validates the spike protein target. We didn't know these things before today, and it's good news for all #COVID19 vaccines in development. 1/
https://twitter.com/saraecook/status/1319739200502194179To be clear, it's not impossible, and OWS surely has assumptions to support this. And yes we must be ambitious.