As kidney replacement therapies (KRT) have become a strained and limited resource during the #COVID19 pandemic, here is a quick #tweetorial on how these treatments work:
What is the main mechanism by which clearance is achieved during intermittent #hemodialysis?
2/
KRT has 2 powers:
1⃣Clearance (removal of solutes, like potassium 🍌)
2⃣Volume removal 💧
...and it comes in 2 flavors:
1⃣Intermittent
2⃣Continuous
Mar 17, 2020 • 10 tweets • 6 min read
1/ In light of the conversion of many of our interactions to virtual experiences, a #tweetorial on @zoom_us features that may enhance your teaching/conferences/meetings etc (No COI to disclose)
HLAs = cell surface proteins encoded by highly polymorphic major histocompatibility complex (MHC) genes on Ch 6 🧬
In #transplantation, HLA proteins are #polymorphic antigens ➡️ alloreactive trigger for the immune response ➡️ can ultimately lead to organ #rejection ☠️
It was isolated from a soil sample from which island in 1975?
2/ Meet mTOR, a phosphatidylinositol 3-kinase (PI3)-related kinase (adds a phos). mTOR adds a phosphoryl group to serine/threonine residues.
It is a key component of the complexes mTORC1 and mTORC 2 - which regulate processes including cell growth, proliferation, and survival.
The main mechanism of action of MPA is inhibition of which of the following:
2/ Let's meet the players. Mycophenolate mofetil (MMF, left) is a prodrug of MPA while mycophenolate sodium (MPS, right) is an enteric-coated salt of MPA.
MMF administration releases MPA in the stomach, while mycophenolate sodium (MPS) releases it in the small intestine.
Jun 25, 2019 • 10 tweets • 6 min read
1/
A brief #tweetorial on the calcineurin inhibitors #CNI and their toxicities. Let's start with a quick poll.
Which of the following describes the main mechanism of action of #CNI?
2/
On to the mechanism of #CNI. Calcineurin inhibitors bind to the "immunophiliins" for which they are named. Cyclosporine (CsA) binds cyclophilin and tacrolimius(FK506) binds FK binding protein.
The CNI-immunophilin complex is the superhero which then inhibits calcineurin
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