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Let's talk about this study from @KevinH_PhD et al and lipids for a moment. bit.ly/2MT17mM . It is REALLY important to notice that the LDL-C was CALCULATED, not measured. Why do we care? @bigfatsurprise @Dr__Guess @JPMcCarter 1/5
The Friedewald Equation:
LDL-C = Total Cholesterol - (HDL-C + Triglyceride/5)
SO....if triglycerides drop (which they did in this study) it comes down to basic math. Even with changes to HDL (up) and TC these are usually dwarfed by the change in trigs on a ketogenic diet. 2/5
LDL-C = Total Cholesterol - (HDL-C + Triglyceride/5)
SO....if triglycerides drop (which they did in this study) it comes down to basic math. Even with changes to HDL (up) and TC these are usually dwarfed by the change in trigs on a ketogenic diet. 2/5
LDL-C will go up if trigs drop significantly! Now....let's review the papers conclusion: "Switching to the KD was associated with increased cholesterol" (by which they mean LDL-C). Is this a reasonable conclusion?
No. Not unless they looked at a MEASURED value such as ApoB. We saw this in our paper: bit.ly/2WJR7AR. LDL-C goes up but ApoB does not change as the LDL-C was calculated and there was a significant drop in trigs. These details matter! 4/5
Now the ApoB may have gone up as well in this study. However, you would need to LOOK at that to make a reasonable conclusion on lipids which they did not. The conclusion on a calculated LDL-C value is fluff, not science. 5/5 @ethanjweiss
