I'm a bit concerned that newer indie game devs are getting overwhelmed reading about all the small optimizations they could be making to promote their games. If you can do it all, great, but it's not always worth the added stress. Don't get lost in the weeds.
As an indie, it's very likely you're doing promotion on the game you're also making. That is SO MUCH WORK. It's good to acknowledge that. Also, I feel like so much of your fate is decided before you even start promoting. You might be squeezing blood from a stone after a point.
Sadly, I think the games that are helped most by optimizing are also the ones that need the help LEAST overall. If your game is naturally appealing to the mainstream (note that I'm not saying "good", "worthwhile", or "artistic"), then that extra effort will come more into play.
A broad stroke would be like: put out a nice trailer and if there's not much interest, then consider wrapping up the project early and moving on to the next game with what you've learned. It makes more sense to me to optimize after a trailer that's done really well.
I think most people understood what I meant in this thread, but just to clarify: you definitely need to promote your game, but a lot of things you could do are like 0.01 multipliers for quite a bit of work. Whether that's worth it depends a lot on you and your project.
