, 6 tweets, 7 min read
My Authors
Read all threads
🍪🍪🍪🍪Giant Cells🍪🍪🍪🍪


What better way to kick-start the new year🎇than with a tweetorial/#RolaCoaster ?
Specifically made for the #pathtwitter family💝
Hope you enjoy the🎢!

#BSTPath @kells108 @natasharekhtman

Can you tell these 2 giant-cell rich lesions apart❓🧐

Answer is coming in Part2️⃣ of this #Tweetorial

#BSTPath @kriyer68 @Histopatolomon @HENRYY_MD @ADamronMD @D4L14H @AlanPath @padmapathology1 @DrMarkOng @MBBS_Pathology
@Chucktowndoc @RunjanChetty @pembeoltulu

▪️Why is this distinction difficult❓🤔
- Location is unknown
- Architecture not appreciated
- Age unknown

- Radiology is 🔑
(closest thing to gross
specimen is the black/
white ‘negative’ image!)

Regarding location, ask yourself:
☠️What bone❓
- Long e.g. femur
- Flat e.g. rib
- Small tubular e.g. phalanx

☠️If long🦴, which part❓
- Epiphysis
- Metaphysis
- Diaphysis

☠️Where in relation to cortex/medulla❓
- Intramedullary
- Intracortical
- Surface

Role of the osteoclastic giant cells:

🍪Non-neoplastic bystanders
🍪The sneaky guys are actually the mononuclear stromal cells which secrete cytokines & other factors
🍪These paracrine signals induce osteoclast proliferation and activation
🍪Net result: bone resorption

Gross specimen of an osteolytic tibial lesion in an adult👇🏻

Based on epiphyseal location alone, what are the 3 top differentials❓

Stay tuned for Part2️⃣❗️
Missing some Tweet in this thread? You can try to force a refresh.

Enjoying this thread?

Keep Current with Rola Ali, MD

Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

Twitter may remove this content at anytime, convert it as a PDF, save and print for later use!

Try unrolling a thread yourself!

how to unroll video

1) Follow Thread Reader App on Twitter so you can easily mention us!

2) Go to a Twitter thread (series of Tweets by the same owner) and mention us with a keyword "unroll" @threadreaderapp unroll

You can practice here first or read more on our help page!

Follow Us on Twitter!

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just three indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!