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The study's actual conclusion is "larger sample size study needed." Also both control patients and patients on HCQ appear to have also received Kaletra and a number of other interventions. So the media's use of "regular care" may be misleading. bloomberg.com/news/articles/…
Study (mostly in mandarin): subject.med.wanfangdata.com.cn/UpLoad/Files/2…

English translation via Google Translate: drive.google.com/open?id=1VSyiI…
End point: all patients ultimately improved and survived.
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AssocAmerPhys&Surg
@AAPSonline
Dear @olgakhazan, You write: "the AAPS doesn’t seem to offer a solution for the fact that these days, a single 'How can we help you?' from a doctor can result in a five-figure bill." (thread) 1/12
You're right. We don't offer "a solution." We advocate for *many* solutions — solutions that are already successfully driving down the cost of high-quality medical care in the real world. 2/12
One solution is Direct Primary Care. DPC offers patients nearly unlimited access to primary care, from a physician, for a monthly fee that is most often in the mid two digits. See for instance: greenhillsdirectfamilycare.com/pricing-fees/ 3/12
Read 12 tweets

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Daniel Sinclair
@_DanielSinclair
A really heartbreaking sight. The sacrifices from health workers in China have been immense.
This is the context of that video, reportedly related to the death of hospital director Liu Zhiming.
This is making the rounds, claiming to be Chinese escaping the country into Vietnam. I'm almost certain that it is misrepresented, and that this is not true.
Read 2899 tweets
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Daniel Sinclair
@_DanielSinclair
If containment fails, and this projection comes true, the hardships that the world would experience during the onset of the first coronavirus pandemic would be hard to comprehended through our current eyes. A first for the modern world.
That’s further out, but if COVID-19 does break through to influenza scale, the benefit would be in a substantial population of immunity & antibodies. Those prospects are now where China is focusing. Antibody donation could improve outcomes; that’s moving from secondary priority.
The best outcome of a worst case scenario would be herd immunity. But, millions would die, medical infrastructure would be overwhelmed at even a fraction of the early generational spread, & the world would be on pause. Transfusion is not the golden ticket; you need a lot of infra
Read 2852 tweets
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Daniel Sinclair
@_DanielSinclair
Unsurprisingly, more information was withheld by the Chinese government. COVID-19 had reached Guangdong by January 4th. Wuhan's lockdown only began on the 23rd. This is a probelm far bigger than Hubei and China.
Alternate reality: Theranos Ends Pandemic
It's so sad to read these stories of China's state of unrest. Trust is degraded. This is not a society that will return to normal with a snap of fingers and bans lifted. China is damaged, could be for years, & we're not even near the end of this epidemic.
Read 2850 tweets
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Daniel Sinclair
@_DanielSinclair
If you're looking for someone compromised on China, you have this theater and its 'unbreakable friendship.' news.yahoo.com/china-declines…
Xi's latest appearance on a call with Trump this morning is a different story, merely parroting the "People's War" language that state media has orchestrated in recent days
This question has only deepened for Chinese and the world in recent days, with the tragedy only growing day after day, and Wuhan's whistleblower now fallen: where is Xi Jinping? time.com/5778994/corona…
Read 2810 tweets
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Daniel Sinclair
@_DanielSinclair
@CDCgov While I wait for more info to develop in the coming days, make sure to follow @JaneLytv's fantastic coverage of the misinformation that is spreading:
@CDCgov @JaneLytv This is absolutely untrue and there is no reporting to validate it. What is happening in Wuhan is not related to a biological weapon, or a human-caused accidental release, and this emergent reporting of a Chinese national being removed from a Canadian lab is in no way related. Image
@CDCgov @JaneLytv This is trash reporting that is by definition fake news. The Wuhan coronavirus was not released by a lab, and there is no evidence to in any way suggest that. washingtontimes.com/news/2020/jan/…
Read 2700 tweets
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Cecile Janssens
@cecilejanssens
Study finds a new test that can check if a breast tumor was effectively removed:

"Its test ... was up to 100 times more sensitive than other similar liquid-biopsy tests in picking up DNA shed by breast cancer cells into the blood."

Wow!
1/3
h/t @pash22
bit.ly/2GUxSe0?utm_so…
"After neoadjuvant therapy, ctDNA concentrations were lower in patients who achieved pathological complete response compared to patients with residual disease (... AUC = 0.83)."
"These results demonstrate high accuracy for assessment of ... residual disease"

Wow!
2/3
Here is the accompanying ROC plot. A reminder that the study was conducted in only 33 patients.

--> waaayyyyyy more research is needed ... in larger sample size too show that this test shows presents a smooty ROC curve with similar AUC. Based on this graph: no guarantee.
3/3
Read 3 tweets

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