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Respuesta inmunitaria innata demasiado exuberante a la infección por SARS-CoV-2
papers.ssrn.com/sol3/papers.cf…
La expresión de los genes proinflamatorios, especialmente las quimiocinas, está notablemente elevada en los casos de COVID-19 en comparación con los pacientes con neumonía adquirida en la comunidad y los controles sanos, lo que sugiere que se produce una hipercitoquinia.
Se perfilan las firmas moleculares de la respuesta del huésped a la infección por SARS-CoV-2, lo que podría ayudar a comprender la patogénesis de la enfermedad y proporcionar pistas para estrategias antivirales personalizadas, como la terapia con IFN.
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