Thread by @LaurelCoons

#Coronavirus Reinfection:

🧬1st infection: March (symptomatic)

🧬2nd infection: August (asymptomatic)

🧬Two virus genomes differed by 24 nucleotides

🧬Proves that 2nd infection was not tied to 1st infection

🧬2nd infection caused by #reinfection, not prolonged viral shedding

Neutralizing Antibody:

🧬Tested NEGATIVE for IgG against SARS-CoV-2 nucleoprotein 10 days after symptom onset of 1st infection AND 1 day after hospitalization for 2nd infection

🧬Thus unknown if patient mounted neutralizing antibody response to 1st infection, didn’t last if yes

Immune Response Following 2nd Infection:

🧬Patient tested POSITIVE for IgG against SARS-CoV-2 nucleoprotein 5 days after hospitalization for 2nd infection

🧬Most patients do develop immune response to infection, unclear how #strong that immune response is and how long it #lasts

Ehhh:

🧬Don’t like that thread assumes patient mounted neutralizing antibody response to 1st infection (not detected after 1st or beginning of 2nd)

🧬If undetected immune response did occur after 1st (and disappeared before 2nd), thread assumes it played a role in 2nd infection

https://twitter.com/virusesimmunity/status/1297890418168860674