Profile picture
Laurel Coons 🧬🧬🧬
@LaurelCoons
, 6 tweets, 7 min read Read on Twitter
Data Needs A Home:

🧬The population of every DNA word is equivalent to the population of its reverse-complement DNA word in the SINGLE-STRANDED human genome

🧬Population count of 1.4 trillion DNA words

🧬Does anyone want a copy of this data before files are deleted?

#Genomics
Can You Use This #Data?

🧬Demonstrates the inherent inversion symmetry structure for all DNA elements in the single-stranded genome

🧬Demonstrates the absence of analog symmetries between reverse pairs and complement pairs of DNA elements

#BigData
🔂

👉cell.com/iscience/fullt…
Do You Know Anyone 🏷 Who Can Use This Data?

🧬The number of times every #DNA element (1-nt to 20-nt) occurs in the single-stranded genome

🧬This inversion symmetry structure is also maintained at the level of each individual #chromosome, except chromosome M (mitochondrial DNA)
Data Will Be #Deleted On Monday

🧬@NIH is going to delete all the data associated with this publication (in press) on #Monday

🧬If you are interested in having a copy of this data before it is deleted, contact me

Data Preview
👉dropbox.com/sh/b52vi5ugt3n…
👉cell.com/iscience/fullt…
Data Size:

Population count of 1.4 trillion DNA elements in the #human (hg19) and #mouse (mm10) genome [full genome and by chromosome] is ~4TB uncompressed or ~600GB compressed #Total

🧬DNA element
🧬Reverse-complement DNA element
🧬Reverse DNA element
🧬Complement DNA element
Home Sweet Home:

🧬This #data now has a permanent home thanks to @textfiles @internetarchive

🧬The population of every DNA element is #equivalent to the population of its reverse-complement DNA element in the SINGLE-STRANDED genome

#Genomics
#BigData

👉archive.org/details/Laurel…
Missing some Tweet in this thread?
You can try to force a refresh.

Like this thread? Get email updates or save it to PDF!

Subscribe to Laurel Coons 🧬🧬🧬
Profile picture

Get real-time email alerts when new unrolls are available from this author!

This content may be removed anytime!

Twitter may remove this content at anytime, convert it as a PDF, save and print for later use!

Try unrolling a thread yourself!

how to unroll video

1) Follow Thread Reader App on Twitter so you can easily mention us!

2) Go to a Twitter thread (series of Tweets by the same owner) and mention us with a keyword "unroll" @threadreaderapp unroll

You can practice here first or read more on our help page!

Related hashtags

#Genomics #data #BigData #DNA #chromosome #Deleted #Monday #human #mouse #Total #equivalent

More from @LaurelCoons see all

Profile picture
Laurel Coons 🧬🧬🧬
@LaurelCoons
National DNA Day:

🧬April 25

🧬Commemorates the day in 1953 when Watson, Crick, Wilkins, Franklin and colleagues published papers in the journal @nature on the structure of DNA

🧬Also commemorates the completion of the Human Genome Project in April 2003, took 13 years

#DNADay
DNA Double Helix:

🧬The two #DNA strands are reverse-complements

🧬Reading one strand in #reverse order and exchanging each base with its #complement gives the other strand

🧬A and T are complements, C and G are complements

DNA Sequence: AGTAGCAT
Reverse-Complement: ATGCTACT
In #Each DNA Strand:

🧬Pull the #DNA double helix apart, leaving the two single DNA strands

🧬The population (or occurrence) of every DNA sequence in that single-strand is #equivalent to the population of its reverse-complement DNA sequence in that same single-strand

#Genomics
Read 5 tweets
Profile picture
Laurel Coons 🌀🔬
@LaurelCoons
DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin:

1336 Datasets:

Defining NR Functional Enhancers (NRFEs)
#sNRFunctionalNRFE

Enhancer Activation
#IndicatorNRFE

sNR Cross-Talk
#sNRCrossTalkNRFE

doi.org/10.1210/en.201…
Functional Genomics:

📌Describes the relationship between an organism’s genotype (genetic makeup, DNA sequence) and phenotype (observable traits) on a global scale

📌A key characteristic is the genome-wide scale, rather than a more traditional “gene-by-gene” approach

#Genomics
DNA→RNA→Protein:

📌Genes:
-Blueprint for life
-Made of DNA
-Act as instructions to make proteins

📌Gene Expression:
DNA sequence is first copied to make an RNA molecule (transcription),
which is then "decoded" to build a protein (translation)

Proteins=Building Blocks Of Life
Read 8 tweets

Related threads

Profile picture
Values, believing, independent thinking, teamwork
@Bruno_Brunelli
In July 1969 the Apollo 11 astronauts conducting several tasks during extravehicular activity (EVA) operations on the surface of the moon. The EVA lasted approximately 2.5 hours with all scientific activities being completed satisfactorily. #OneGiantLeap

Filmmaker, TV network take small steps to #NeilArmstrong biopics:

#FirstMan #LandingOnTheMoon #OneGiantLeap

collectspace.com/news/news-0929…
#Apollo11 landed on the Moon on July 20, 1969.

That's #OneSmallStep for [a] man, #OneGiantLeap for mankind.

Read 54 tweets
Profile picture
NordicFoodPolicyLab
@nordicfoodpol
For the first time ever, movers and shakers met to discuss #data needs, available #policy options and the opportunities for different sectors in the transition towards #healthy and #sustainable #foodsystems in the #Baltic region

#nordicsolutions norden.org/en/news/baltic…
Participants jointly mapped forces at play in transition to more sustainable & healthy diets in Baltic region which ensured:
🌟High levels of participation and local ownership
🌟Common narrative & theory of change
🌟Better understanding of priority areas + system leverage points
With agreement on the urgency to act and the system leverage points, 3 joint projecs were conceived:
🍽️🌍 Define & develop criteria for sustainble healthy Baltic diet
💻👩‍🔬 Coordinate existing data across the region
🌬️💡Create Baltic future food “lab” for new innovative ideas
Read 3 tweets
Profile picture
Enlightening Results
@GraceCordovano
Major points here (thread):
👉outrageous, disgraceful, not surprising as its cut throat business as usual; guarantee @Facebook isn’t the only organization doing what it takes to get ahead #transparency #privacy #SocialMedia #data #hcldr #ThursdayThoughts

techcrunch.com/2019/01/29/fac…
2) 👉@Apple didn’t “know” until the headlines broke & they want to be the “guardian of our health” 🤨 Please 🤯 #transparency #privacy #SocialMedia #data #healthcare #digitaltech #innovation #hcldr
3) 👉targeting children & their #data needs to be recognized as digital trafficking & punishable by law #transparency #privacy #SocialMedia #data #healthcare #digitaltech #innovation #hcldr
Read 6 tweets
Profile picture
WarNuse
@WarNuse
European Union’s Highest Court Deals A Blow To Science.

By Gretchen Vogel, June 27, 2017.

We KNOW People Of Wealth Have Been Subverting Vaccines For Decades. There Needs To Be Room Made For These Criminals At Guantanamo.

sciencemag.org/news/2017/06/d…

#QAnon #GreatAwakening @potus
'Where There Is A Lack Of Scientific Consensus, The Proof Of The Defect Of The Vaccine And Of A Causal Link Between The Defect And The Damage Suffered May Be Made Out By Serious, Specific And Consistent Evidence.'

EU Report, June 21, 2017.

curia.europa.eu/jcms/upload/do…

#QAnon @potus
Gates Foundation Kicked Out Of India.

'The Gates Foundation Has For Years Funded ITSU Which Provides Strategy And Monitoring Advice For New Delhi’s Massive Immunization Program That Covers About 27 Million Infants Each Year.'

February 10, 2017.

newspunch.com/india-bill-gat…

#QAnon
Read 97 tweets
Profile picture
Paula Loves Children ⭐️⭐️⭐️❤️ #SaveTheChildren
@paulacblades001
1/ WHAT IF I TOLD YOU OF A SECRET WAR, a war for control of “YOUR DNA?” What if they had the cures for many Diseases but instead used this knowledge to Create Illness Instead 😱 #VictimsForProfit
#DNAEditing #ReleaseTheCure #Matrix #QAnon #WWG1WGA
@realDonaldTrump @GenFlynn
2/ Each living Organism has it's own Genetic Code... #DNA is the Genetic Map of “YOU”. It holds detailed codes from your Parents/Ancestors, including your strengths & weaknesses...
#VictimsForProfit
#QAnon #WWG1WGA
@realDonaldTrump @GenFlynn
👉🏻en.wikipedia.org/wiki/DNA
3/ United States Department of Energy Cites “Q Clearance” as a “National Security Position” of “Critical & Sensitive Matters.” The #DOE had full Oversight of the
👉🏻#HumanGenomeProject 👈🏻 🤔
@realDonaldTrump @GenFlynn #WWG1WGA #QAnon #BioSimilars
👉🏻en.wikipedia.org/wiki/Q_clearan…
Read 41 tweets
Profile picture
Ilhan Omar
@IlhanMN
Home
no one leaves home unless home chases you
fire under feet
hot blood in your belly
it’s not something you ever thought of doing
until the blade burnt threats into
your neck
and even then you carried the anthem under
your breath

#home #warsanshire #poems
#WhereAreTheChildren
only tearing up your passport in an airport toilets
sobbing as each mouthful of paper
made it clear that you wouldn’t be going back.

you have to understand,
that no one puts their children in a boat
unless the water is safer than the land
no one burns their palms
under trains
beneath carriages
no one spends days and nights in the stomach of a truck
feeding on newspaper unless the miles travelled
means something more than journey.
no one crawls under fences
no one wants to be beaten
pitied
Read 8 tweets

Trending hashtags

#NigeriaDecides2019 #RaceRealism #FirstMan #Jews #human #tech #DOE #ClintonCrimes #Gold #inspired #optimism #Iraq #UN #hours #memristive #poems #Matrix #Therapy #digital #QuantumEntanglement #Peptides #AluElements #BhagavadGita #healthcare #speakers
Follow Us on Twitter!

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just three indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!