Thread by @LaurelCoons

National DNA Day:

🧬April 25

🧬Commemorates the day in 1953 when Watson, Crick, Wilkins, Franklin and colleagues published papers in the journal @nature on the structure of DNA

🧬Also commemorates the completion of the Human Genome Project in April 2003, took 13 years

#DNADay

DNA Double Helix:

🧬The two #DNA strands are reverse-complements

🧬Reading one strand in #reverse order and exchanging each base with its #complement gives the other strand

🧬A and T are complements, C and G are complements

DNA Sequence: AGTAGCAT
Reverse-Complement: ATGCTACT

In #Each DNA Strand:

🧬Pull the #DNA double helix apart, leaving the two single DNA strands

🧬The population (or occurrence) of every DNA sequence in that single-strand is #equivalent to the population of its reverse-complement DNA sequence in that same single-strand

#Genomics

Decoding Our DNA:

The #population of every DNA sequence is equivalent to the population of its reverse-complement DNA sequence in

🧬Both DNA strands of the double helix

🧬Each single-strand of the double helix

🧬Each chromosome of each single-strand

👉cell.com/iscience/fullt…

DNA Code:

🧬#Transcription factor binding in the genome follows this reverse-complement symmetry

🧬It’s the DNA code that transcription factors (proteins that turn genes on or off) use to interact with the genome, and dictates which of those interactions are functionally active