@TheLancet journals now require all #research papers, irrespective of method, to include a data-sharing statement that details what #data will be shared, whether additional documents will be shared, when data will become available & by what access criteria data will be shared.
All @TheLancet journals will now introduce additional peer-review requirements for papers based on large, real-world datasets.
Editors will ensure that at least one peer reviewer is knowledgable about the details of the #dataset being reported & can understand & comment on its strengths & limitations in relation to the #research question being addressed.
For studies that use very large #datasets, editors will ensure that in addition to statistical peer review, a review from an expert in #data science is obtained.
@TheLancet will explicitly ask reviewers if they have concerns about research integrity or publication ethics regarding the manuscript they are reviewing.
Changes to the signed declarations by authors in the author statements form will require that more than one author has directly accessed & verified the #data reported in the manuscript.
@TheLancet will require that the authors who have accessed & verified underlying #data are named in the contributors' statement.
For research articles that are the result of an academic + commercial partnership, one of the authors named as having accessed & verified data must be from the academic team.
All authors will be asked to sign the author statements form to confirm they had full access to the #data reported in their article & accept responsibility for submitting the article for publication.
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Emerging data from @PHE_uk suggests a synergistic detrimental effect of co-infection with #SARS_CoV_2 & #flu viruses. The preprint (not peer reviewed) article is available here medrxiv.org/content/10.110…
‘The risk of testing positive for #SARS_CoV_2 was 68% lower among #influenza positive cases, suggesting possible pathogenic competition between the two viruses.’
However, ‘Patients with a coinfection had a risk of death of 5.92 (95% CI, 3.21-10.91) times greater than among those with neither influenza nor SARS-CoV-2 suggesting possible synergistic effects in coinfected individuals.’
Advances in #cancer treatment have improved clinical outcomes, leading to an increasing population of cancer survivors. Yet, this success is associated with high rates of short‐ & long‐term #cardiovascular toxicities. The Cancer Patient and Cardiology onlinelibrary.wiley.com/doi/abs/10.100…
The number & variety of #cancer drugs & #cardiovascular toxicity types make long‐term care a complex undertaking.
This requires a multidisciplinary approach including expertise from #oncology, #cardiology, & other related specialties, & has led to the development of the cardio‐oncology subspecialty.
The rise in admissions with #COVID19 does not mean that you shouldn’t attend hospital if you have a medical emergency #heartattack
During the first peak, admissions with #heartatrack declined & was of grave concern : COVID-19 pandemic and admission rates for and management of acute coronary syndromes in England @TheLancetthelancet.com/journals/lance…
Yet, hospitals provided high quality care for those who did attend: Patient response, treatments and mortality for acute myocardial infarction during the COVID-19 pandemic @ESC_Journals#EHJQCCOacademic.oup.com/ehjqcco/advanc…
Patients with mitral annular disjunction present with frequent premature ventricular contractions; in this study, one-third had ventricular arrhythmias & one-tenth had severe arrhythmic events. @JACCJournalsonlinejacc.org/content/72/14/…
A total of 82 (71%) patients reported #palpitations, 47 (41%) patients reported previous pre-syncope, 40 (34%) had ventricular arrhythmia, 15 (13%) had experienced #syncope, & 14 (12%) patients had experienced a severe arrhythmic event prior to inclusion
Mitral valve prolapse was present in 90 (78%) patients
This cluster randomised controlled trial found that opportunistic screening in primary care did not increase the detection of #AFib compared with usual care in patients aged 65 & over @bmj_latestbmj.com/content/370/bm…
Yet the findings are in contrast to the SAFE study which showed that opportunistic screening for #atrialfibrillation over a year detected more new diagnoses than usual care.