1/13 - “To fight a super-spreading disease effectively, policy makers need to figure out why super-spreading happens, and they need to understand how it affects everything, including our contact-tracing methods and our testing regimes.” Via @Pierre_mHealth theatlantic.com/health/archive…
2/13- “We see that super-spreading clusters of #COVID19 almost overwhelmingly occur in poorly ventilated, indoor environments where many people congregate over time-weddings,churches,choirs, gyms,funerals,restaurants, and such-when there is loud talking or singing without masks.”
3/13 - “Prolonged contact, poor ventilation, a highly infectious person, and crowding [are] the key elements for a super-spreader event.”
4/13- “Overdispersion should inform our contact-tracing efforts. Right now, many states engage in forward or prospective contact tracing. Once an infected person is identified, we try to find out with whom they interacted afterward so that we can warn, test, isolate, quarantine.”
5/13 - “[prospective contact tracing] will merely identify potential exposures, many of which will not happen anyway, because most transmission chains die out on their own.”
6/13 - “If we can use retrospective contact tracing to find the person who infected our patient, and then trace the forward contacts of the infecting person, we are generally going to find a lot more cases compared with forward-tracing contacts of the infected patient.”
7/13 - “Forward tracing alone can, on average, identify at most the mean number of 2nd infections (=R); backward tracing increases this maximum nb of traceable individ by a factor of 2-3,as index cases are more likely to come from clusters than a case is to generate a cluster.”
8/13 - “It’s not pointless to do forward tracing to be able to warn and test people, if there are extra resources and testing capacity. But it doesn’t make sense to do forward tracing while not devoting enough resources to backward tracing and finding clusters.”
9/13 - “Once a country has too many outbreaks, it’s almost as if the pandemic switches into “flu mode,” meaning high, sustained levels of community spread even though a majority of infected people may not be transmitting onward.”
10/13 - “Perhaps one of the most interesting cases has been Japan, a country with middling luck that got hit early on and followed what appeared to be an unconventional model, not deploying mass testing and never fully shutting down.”
11/13 -“Japan thus carried out a cluster-busting approach,including undertaking aggressive backward tracing to uncover clusters.Japan also focused on ventilation,counseling its population to avoid places where the three C’s come together—crowds in closed spaces in close contact.”
12/13 - “Japan’s commitment to ‘cluster-busting’ allowed it to achieve impressive mitigation with judiciously chosen restrictions. Countries that have ignored super-spreading have risked getting the worst of both worlds: burdensome restrictions that fail to achieve mitigation.”
13/13 - “Could we get back to a much more normal life by focusing on limiting the conditions for super-spreading events, aggressively engaging in cluster-busting, and deploying cheap, rapid mass tests?”

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More from @FLAHAULT

12 Oct
1/8 - Il y a deux modalités de traçage des contacts:
a) Traçage prospectif, classique, on recherche les contacts du cas;
b) Traçage rétrospectif,”à la japonaise”,on recherche qui a contaminé le cas.
La priorité des priorités c’est de privilégier b) et ne faire a) que si on peut.
2/8 - Le fondement théorique vient du paramètre k de dispersion, élevé pour la grippe (de dynamique homogène) et faible pour le #SARSCoV2 dont la dynamique est hétérogène, émerge en clusters et en événements super-propagateurs: 10 à 20% des contaminations drive toute la pandémie.
3/8 - Si 80-90% des cas contaminent 0 ou 1 cas, on n’a pas à se fatiguer à tracer leurs contacts. Ils ne nous inquiètent pas. En revanche, il faut tout mettre en œuvre pour stopper la propagation causée par les 10 ou 20% restants, à commencer par les identifier. Comment faire ?
Read 8 tweets
12 Oct
1/21. Oct 13 to Oct 19 - #COVID19 Daily Epidemic Forecasting in 209 countries for cases, deaths, tests, R-eff, risk maps (21 of them analyzed below).
Data: @ECDC_EU coronavirus.jhu.edu ourworldindata.org/coronavirus

renkulab.shinyapps.io/COVID-19-Epide…

Powered by @ISG_UNIGE & @SDSCdatascience Image
2/21. Austria is experiencing a rise in its #COVID19 case incidence, with increasing -although low- levels of mortality.

Note: our 7-day forecasting does not sound accurate for Austria, we are working on our models to improve their predictive accuracy. ImageImage
3/21. Italy will be experiencing a rapid and worrying surge in its #COVID19 epidemic activity foreseen to reach high level after mid-October, with very low levels of mortality, for 7 more days. ImageImage
Read 23 tweets
11 Oct
1/5 -
Tentons de mettre sur la table toutes les mesures qui fonctionnent pour éviter un nouveau confinement :
1. Testing/Tracing/Quarantaine-Isolement rétrospectif prioritaire pour prévenir clusters et super-propagation (=approche japonaise)...
2/5-
... Et si capacités restantes le permettent, en +, Test/Trac/Isol prospectif classique (=recherche des contacts des cas);
2. Promotion très active du télétravail à chaque fois que possible;
3. En tous lieux clos:port du masque+distance physique+ventilation+mesures d'hygiène
3/5 -
4. Dans les zones à risque (>4,3 cas #COVID19/100Kpop/jour):
a) Fermeture des cours présentiels aux collèges, lycées et universités, et remplacement par enseignement à distance;
b) Fermeture des bars, restaurants, discothèques; promotion des terrasses.
...
Read 6 tweets
11 Oct
1/21. Oct 12 to Oct 18 - #COVID19 Daily Epidemic Forecasting in 209 countries for cases, deaths, tests, R-eff, risk maps (21 of them analyzed below).
Data: @ECDC_EU coronavirus.jhu.edu ourworldindata.org/coronavirus

renkulab.shinyapps.io/COVID-19-Epide…

Powered by @ISG_UNIGE & @SDSCdatascience Image
2/21. Austria is experiencing a rise in its #COVID19 case incidence, with increasing -although low- levels of mortality.

Note: our 7-day forecasting does not sound accurate for Austria, we are working on our models to improve their predictive accuracy. ImageImage
3/21. Italy will be experiencing a rapid and worrying surge in its #COVID19 epidemic activity, with very low levels of mortality, for 7 more days. ImageImage
Read 23 tweets
11 Oct
1/9 - “[Urugay]’s response [to #COVID19] could offer various lessons to [Latin America] and the world, among them how to test more efficiently using a system first pioneered to tackle syphilis during the second world war.” bmj.com/content/370/bm…
2/9 - “Uruguay’s president, Luis Lacalle Pou acted promptly when Uruguay’s first case was confirmed on 13 March. [He] announced that all public events and potential centres of crowding such as bars, churches, and shopping centres would be shut down. Schools were also closed.”
3/9 - “Lacalle Pou asked rather than ordered people to stay at home to protect the population, the oldest in Latin America.”
Read 9 tweets
10 Oct
1/21. Oct 11 to Oct 17 - #COVID19 Daily Epidemic Forecasting in 209 countries for cases, deaths, tests, R-eff, risk maps (21 of them analyzed below).
Data: @ECDC_EU coronavirus.jhu.edu ourworldindata.org/coronavirus

renkulab.shinyapps.io/COVID-19-Epide…

Powered by @ISG_UNIGE & @SDSCdatascience
2/21. Switzerland is experiencing a worrying surge in its #COVID19 case incidence, with increasing -although low- levels of mortality.

Note: Due to discontinuity in reporting its surveillance data to international networks, 7-day predictions are not reliable for the country.
3/21. Italy will be experiencing a rapid surge in its #COVID19 epidemic activity, with very low levels of mortality, for 7 more days.
Read 23 tweets

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