@JulieTheCranky 2019 letter from expert/advocates (thank you @StefanKertesz) & signed by 3 former US “drug czars" & 318 additional healthcare professionals asked CDC to restate what's NOT in the Guideline: no dose cap; no call for forced tapers.
@JulieTheCranky@StefanKertesz@CDCgov#CDC Director Redfield (4/2019): the Guideline calls for doctors to reduce or stop opioids “only [in bold] when patient harm outweighs patient benefit” & does not include a dosage cap. 3/
@JulieTheCranky@StefanKertesz@CDCgov .@CDCgov 4/2019: 90 MME threshold "focuses on initiation." As Redfield notes, the rx #opioid Guideline was meant to help PCPs decide when & how to begin long-term opioid therapy. It recommends treatment begin at a dose below 90 MME. 4/
@JulieTheCranky@StefanKertesz@CDCgov CDC Director 4/2019: The Guideline was meant to provide doctors information about how to best decrease dosages "if a patient would like to taper." 5/
@JulieTheCranky@StefanKertesz@CDCgov CDC Director's 4/2019 letter isn't news. The Guideline does NOT call for #opioid bans much less forced tapers. I quoted those sentences back in 2016 or 2017 when I testified against Maine's bill to set a 100 MME cap by law. (I lost.) 6/
@JulieTheCranky@StefanKertesz@CDCgov In 2019, the fed gov't published a clinician's guide to patient-centered dose reduction, which again says forced tapers should be restricted to life-saving emergency situations. It again says risk/benefit should be done case by case (no bans). 7/ jamanetwork.com/journals/jama/…
@JulieTheCranky@StefanKertesz@CDCgov CDC waited too long to "clarify" the policy. Policymakers "believe" medical use fuels illegal use & therefore ODs. It does not. They "believe" rx cuts have saved lives. In fact, they've accelerated deaths.
3/15/2016: CDC Director Frieden said the Guideline would result in “fewer deaths from all sorts of opiates.”
✔️2018: CDC published a paper showing that #opioid overdose deaths go UP as prescriptions go down. CDC has not yet retracted the Guideline.
2) Frieden (3/15/2016): “The prescription overdose epidemic is doctor-driven."
✔️US OD deaths have been "inexorably tracking along an exponential growth curve since at least 1979," a "predictable pattern of growth" that's NOT associated with increases OR decreases in scripts.
Late in CDC's 2016 Guideline, a table reveals the Agency had no solid evidence for its claim that reducing rx #opioids would reduce ODs without harming people in #pain. In fact, ODs & suicides have spiked in their wake.
Thread: What did CDC know & when did they know it?
In a spring 2016 research paper, the Guideline's authors report that no "rigorous" studies had been conducted on whether dose reductions lower ODs, tho "preliminary results" suggested that high doses are less risky than low doses.
(All references at end of thread.)
CDC conducted its own study using VHA data about vets taking rx opioids. They matched 221 vets who died of OD (some of whom "likely" committed suicide) with 221 vets still living.
They found "dosage was a moderately good ‘predictor’ of opioid overdose death."
#Migraine is the most common & disabling brain disease, but @SocialSecurity still doesn't recognize it as potentially disabling, making it much harder for people to qualify for earned benefits.
🔵Bookmarkable Thread! Info about #SSDI & #disability for migraine.
Severe #migraine is profoundly disabling. The World Health Organization uses objective metrics to determine disease burden & ranks severe migraine in the highest category of disability alongside terminal-stage cancer.
2,887 #vets died of #overdose or #suicide after they were taken off #opioids meds by the VA to adhere to guidelines. @StefanKertesz & colleagues found stopping meds increases the risk of death up to 6.8x (study in linked tweet). @headsUPmigraine thanks him for his work.
2,887 #vets died of #OD/suicide after their rx #opioid was stopped in FY2013, only 90 fewer deaths than on 9/11.
Stopping treatment was associated with increased risk of fatal OD/#suicide regardless of the length of treatment (Oliva et al BMJ 2020). 1/3
#Vets whose #opioid med was stopped were 1.67 to 6.77 times more likely to die than those who continued to be treated. Deaths were highest in 1st 3 months after treatment was stopped. 2/3
Tang et al 2006 review: Risk of death by #suicide at least doubled in #ChronicPain patients. Ideation is 3 times more common; lifetime prevalence of about 20%. 8 risks for suicidality in chronic pain were identified, half are physical. researchgate.net/profile/Cather…
Tang et al: 8 risks for #suicide in #ChronicPain patients: 4 are physical, including type, intensity & duration of pain & sleep-onset insomnia co-occuring with #pain; 4 are psychological. CP is a neurological suicide risk AND a psychological risk.
2 dozen senior Trump admin officials fear he'll use gov't power to refuse to leave office or "create favorable terms for negotiating his exit." They worry too about foreign adversaries using the internet to undermine the election. thread> nytimes.com/2020/10/30/opi…
NYT sources: most senior officials w/ Senate-confirmed jobs, regular access to Trump & highest-level briefings; some still serving. Several are currently in Intel, law enforcement, nat'l security & are focused on violent, far-right white supremacy groups encouraged by Trump.
Officials: "in 1st debate, when the president offered one of the most astonishing performances of any leader in modern American history--bullying, ridiculing, manic, boasting, fabricating, relentlessly interrupting & talking over his opponent: that’s really him.... That’s Trump.”