Thread by @DaveKeto

1/ This new MR study by @mendel_random, @mvholmes, et al makes use of UK Biobank data and determines #ApoB increases risk of #AllCauseMortality, and even #T2Diabetes

This is actually relevant timing as we are rapidly approaching the #LMHRstudy. sciencedirect.com/science/articl…

2/ If you didn't already know, "Lean Mass Hyper-responders" (#LMHRs) would be considered hypercholesterolemic, with this resulting from being very low carb (typically #keto), and are often lean and/or athletic.

(You can read more on this phenotype at CholesterolCode.com/lmhr)

3/ Setting aside why this population exhibits this (see #LipidEnergyModel for more), the most important question is whether they are at risk.

This MR study builds on the existing conventional expectation that they are, and no less in a dose-dependent manner...

4/ #LMHRs don't just have high #LDL cholesterol and particle account, they likewise have very high #ApoB.

However, their #HDL-C/-P levels are high and #triglycerides low (which is relevant to the model). But if #ApoB is the central driver of risk, this will have little impact.

5/ This is why the coming study should provide uniquely powerful data as we've never had a population with the variable of interest being so high (in this case, #LDL/#ApoB), yet all other major #CVD risk markers low to test the specificity of this important molecule and risk.

6/ Naturally, I have to fit in obligatory plug => If you care -- as we do -- about studying this important phenotype and what it can help uniquely tell us about risk with high #ApoB, come visit and show your support 👇

citizensciencefoundation.org/campaigns/lean…

(Currently at 93% completion)