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Eric Feigl-Ding Profile picture
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3 Jun, 5 tweets, 5 min read
CELL-to-CELL transmission that avoids antibodies—a new study shows that once cells are #SARSCoV2 infected, they can infect other cells in ways which are very difficult to inhibit with antibodies. Video shows how virus can move between cells. HT @sigallab.
2) So @sigallab wanted to text if antibodies against #SARSCoV2 can neutralize the virus.

Top row, with virus infection *not via cell to cell*, the more antibodies (left), the less virus leftover.

Bottom row: in cell to cell infection, antibodies made zero difference! 👀
3) The implication? Once the infection sets in, the virus can keep proliferating and transmitting cell to cell, avoiding the blood stream or wherever antibodies can access and directly neutralize the virus. #SARSCoV2 is a tricky beast.
4) Thus Dr @sigallab highly recommends vaccines with high neutralization so that it can help prevent the virus from invading into certain cells that can then do cell-to-cell transmission that would “escape” antibodies later.
5) People involved in the work include

@Dr_L_Jackson, the lead on the work, and @sigallab @Tuliodna, @WillemAHanekom, @farinakarim, @coolvirus, @Sandile_Cele22, @houzhou, @KhadijaBKhan24.

biorxiv.org/content/10.110…

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More from @DrEricDing

Eric Feigl-Ding Profile picture
5 Jun
“Immune escape” in #DeltaVariant. That’s the latest finding - that #B16172 is as bad for antibody neutralization as the Beta variant #B1351 from South Africa 🇿🇦. 1st dose alone very small effect— 2 doses needed, but weakest against Delta. Let’s walk through evidence 🧵 #COVID19 Image
2) first, @chrischirp says “Now we have a dominant variant that is as bad as Beta for immune escape but much more transmissible.” — she says that because Beta #B1351 (green) was previously the worst neutralization variant. Now it seems #DeltaVariant is even worse. Image
3) The latest Lancet study also found waning neutralization over time, similar to other variants— but the difference is that #DeltaVariant #B16172 starts from a much lower baseline level to begin with. Image
Read 9 tweets
Eric Feigl-Ding Profile picture
4 Jun
⚠️CDC warns of increased hospitalization rates of teenagers with #COVID19 in March-April, @CDCDirector urged parents to vaccinate teens. “I am deeply concerned by numbers of hospitalized adolescents &… see numbers who required ICU or mechanical ventilation”, citing new MMWR🧵 Image
2) ““Much of this suffering can be prevented,” she said, urging “parents, relatives and close friends to join me and talk with teens” about the importance of prevention strategies and to encourage vaccination.

washingtonpost.com/health/2021/06…
3) “The study showed that nearly one-third of those who were hospitalized with covid-19 during a surge of cases early this year required intensive care, and 5 percent required mechanical ventilation.” cdc.gov/mmwr/volumes/7…
Read 18 tweets
Eric Feigl-Ding Profile picture
4 Jun
ICE THINNING FASTER—New study conclude that Arctic sea ice is thinning twice as fast as before. Especially in key coastal regions was thinning at a rate 70% to 100% faster than previously thought (which before had used outdated data from 20 years ago).

phys.org/news/2021-06-a… Image
2) “To calculate sea ice thickness researchers used radar from the European Space Agency's CryoSat-2 satellite. By timing how long it takes for radar waves to bounce back from the ice, they can calculate the height of the ice above the water—to infer the ice's total thickness.”
3) They also found that, across all seven coastal seas, the variability in sea ice thickness from year to year increased by 58%.
Sea ice in the coastal seas typically varies from 1/2 metre to two metres thick. Increasingly, the ice in this region is not surviving the summer melt.
Read 4 tweets
Eric Feigl-Ding Profile picture
4 Jun
📍Delta variant #B16172:

50-70% more transmissible

2.7x more likely to be hospitalized than #B117

“Many people could end up in hospital, 🇬🇧 NHS could be thrown into another surge.”

Says @globalhlthtwit of @IndependentSage. #COVID19 #DeltaVariant
2) Latest UK @PHE_uk assessment on #DeltaVariant #B16172:

📌Severity is now RED (previously insufficient info)

📌Vaccines is now RED with high confidence (previously moderate) Image
3) Two separate studies on hospitalization severity—one from England 🏴󠁧󠁢󠁥󠁮󠁧󠁿 and one from Scotland 🏴󠁧󠁢󠁳󠁣󠁴󠁿— both found Increased severity of #DeltaVariant #B16172

➡️ Risk of hospital admission (Hazard Ratio = 2.61 in England and HR = 2.39 in Scotland) compared to the Kent variant #B117! Image
Read 11 tweets
Eric Feigl-Ding Profile picture
3 Jun
Vaccine efficacy of Pfizer-BioNTech in Denmark 🇩🇰 for >=7 days after 2 doses:

📍53% in Long Term Care Facilities
📍86% in >=65 years needing homecare
📍77% in >=85 years old
📍80% in frontline healthcare workers
📍73% with #COVID19 high risk factors.
medrxiv.org/content/10.110…
2) For hospitalization admissions overall, 93% efficacy with 2 doses. But 75% efficacy for hospital admissions among those living in long term care facilities.
3) For #COVID19 mortality, 94% efficacy with 2 doses after 7 days. For long term care facilities residents, 89% efficacy against covid mortality. 97% for >=65 needing homecare.

Also interesting 49% efficacy against all-cause mortality!
Read 5 tweets
Eric Feigl-Ding Profile picture
2 Jun
📍STUNNING-Brazil’s @jairbolsonaro apparently intended to lead 🇧🇷 to herd immunity by natural infection, **whatever the consequences**. That means (w/ 1% IFR, 70% herd threshold) by definition he planned for >1.4 mil deaths!

That was the plan!🧵 #COVID19
nytimes.com/2021/05/27/opi…
2) “Here is one example. In March 2020, a social media campaign called “Brazil Can’t Stop” was launched by [Bolsonaro’s] communications unit. Urging people not to change their routines, the campaign claimed “coronavirus deaths among adults & young people are rare.”
3) “The heavily criticized campaign was eventually banned by a federal judge and largely forgotten.
Then the plot thickened. Brazil’s former communications director, Fabio Wajngarten, told the inquiry that he didn’t know “for sure” who had been responsible for the campaign…
Read 23 tweets

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