⚠️CDC warns of increased hospitalization rates of teenagers with #COVID19 in March-April, @CDCDirector urged parents to vaccinate teens. “I am deeply concerned by numbers of hospitalized adolescents &… see numbers who required ICU or mechanical ventilation”, citing new MMWR🧵
2) ““Much of this suffering can be prevented,” she said, urging “parents, relatives and close friends to join me and talk with teens” about the importance of prevention strategies and to encourage vaccination.

washingtonpost.com/health/2021/06…
3) “The study showed that nearly one-third of those who were hospitalized with covid-19 during a surge of cases early this year required intensive care, and 5 percent required mechanical ventilation.” cdc.gov/mmwr/volumes/7…
4) While most covid-19 hospitalizations occur in older adults, severe disease that requires hospitalization has been shown to occur in all age groups. #Covid19 hospitalization rates among adolescents declined in January-February 2021, the report said, but increased March—April.
5) “Researchers suggest increased hospitalization among adolescents may be related to several factors, including more transmissible & potentially more dangerous virus variants, larger numbers of youths returning to school, and changes in physical distancing, mask-wearing”
6) If those prevention measures had not been practiced at all, “the rates of covid-19-associated hospitalization might have been substantially higher,” the report said.
A coronavirus vaccine wasn’t recommended for use in 12- to 15-year-olds until last month.
7) Even though the study is of a small group of adolescents, CDC officials expressed concern about the potential for severe disease and stressed the importance not just of vaccination, but of continued mask-wearing and other preventive behaviors until they are fully vaccinated.
8) “About 70% of adolescents in the study had at least one underlying medical condition, the most common obesity. But nearly 30% had no reported underlying condition, the report said, “indicating that healthy adolescents are also at risk for severe covid-19- associated disease.”
9)Researchers said the cumulative covid-19 hospitalization rates for the adolescents during Oct. 1, 2020 through April 24, 2021 were 2.5 to 3 times higher than seasonal influenza-associated hospitalization rates during three recent flu seasons.
10) Researchers said hospitalization rates may be underestimated since some clinicians may not have ordered tests for the virus, and adolescents hospitalized with Multisystem Inflammatory Syndrome in Children might not be identified if testing after 14 days after hospitalization.
11) Cases have also been rising in the UK as well. They don’t require masks in schools.
13) What is the number one activity prior to symptoms onset in the UK for #COVID19 ? Schools and childcare.
14) What age group does the epidemic first start? Kids 11-16 in the UK 🇬🇧 according to latest PHE report.
15) Recently, Singapore Minister of Health has also sent out a pediatric warning.
16) Indian doctors also concerned about pediatric risk. Particularly severity that has changed.
17) @kavitapmd & I warned about this—“Today, many states are racing toward reopening, allowing even unvaccinated adults and children to congregate in places like churches, schools and stadiums, all while they record thousands of new infections each day.” nydailynews.com/opinion/ny-ope…
18) “we ended up with a state-by-state approach to the pandemic response, generally characterized by limited restrictions when case counts rise, reopening when case counts fall, then reinstating restrictions when cases rise again.” nydailynews.com/opinion/ny-ope…
19) “In the case of some states such as Florida, restrictions were removed despite a surge in the infection rate. After months of this on-again, off-again pattern, we are basically resigned to living with the virus, and many of us are suffering from dangerous complacency.”
20) We needs to be even more cautious about kids risk now that the #DeltaVariant #B16172 is proliferating worldwide. This variant has huge transmission risk in children and likely more severe. See thread.
21) To keeps kids safe we need both masks and ventilation / air quality upgrades in schools, per CDC recommendations. And it’s not that hard or even that expensive actually. Details here in thread 🧵

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More from @DrEricDing

5 Jun
“Immune escape” in #DeltaVariant. That’s the latest finding - that #B16172 is as bad for antibody neutralization as the Beta variant #B1351 from South Africa 🇿🇦. 1st dose alone very small effect— 2 doses needed, but weakest against Delta. Let’s walk through evidence 🧵 #COVID19
2) first, @chrischirp says “Now we have a dominant variant that is as bad as Beta for immune escape but much more transmissible.” — she says that because Beta #B1351 (green) was previously the worst neutralization variant. Now it seems #DeltaVariant is even worse.
3) The latest Lancet study also found waning neutralization over time, similar to other variants— but the difference is that #DeltaVariant #B16172 starts from a much lower baseline level to begin with.
Read 9 tweets
4 Jun
ICE THINNING FASTER—New study conclude that Arctic sea ice is thinning twice as fast as before. Especially in key coastal regions was thinning at a rate 70% to 100% faster than previously thought (which before had used outdated data from 20 years ago).

phys.org/news/2021-06-a…
2) “To calculate sea ice thickness researchers used radar from the European Space Agency's CryoSat-2 satellite. By timing how long it takes for radar waves to bounce back from the ice, they can calculate the height of the ice above the water—to infer the ice's total thickness.”
3) They also found that, across all seven coastal seas, the variability in sea ice thickness from year to year increased by 58%.
Sea ice in the coastal seas typically varies from 1/2 metre to two metres thick. Increasingly, the ice in this region is not surviving the summer melt.
Read 4 tweets
4 Jun
📍Delta variant #B16172:

50-70% more transmissible

2.7x more likely to be hospitalized than #B117

“Many people could end up in hospital, 🇬🇧 NHS could be thrown into another surge.”

Says @globalhlthtwit of @IndependentSage. #COVID19 #DeltaVariant
2) Latest UK @PHE_uk assessment on #DeltaVariant #B16172:

📌Severity is now RED (previously insufficient info)

📌Vaccines is now RED with high confidence (previously moderate)
3) Two separate studies on hospitalization severity—one from England 🏴󠁧󠁢󠁥󠁮󠁧󠁿 and one from Scotland 🏴󠁧󠁢󠁳󠁣󠁴󠁿— both found Increased severity of #DeltaVariant #B16172

➡️ Risk of hospital admission (Hazard Ratio = 2.61 in England and HR = 2.39 in Scotland) compared to the Kent variant #B117!
Read 11 tweets
3 Jun
Vaccine efficacy of Pfizer-BioNTech in Denmark 🇩🇰 for >=7 days after 2 doses:

📍53% in Long Term Care Facilities
📍86% in >=65 years needing homecare
📍77% in >=85 years old
📍80% in frontline healthcare workers
📍73% with #COVID19 high risk factors.
medrxiv.org/content/10.110…
2) For hospitalization admissions overall, 93% efficacy with 2 doses. But 75% efficacy for hospital admissions among those living in long term care facilities.
3) For #COVID19 mortality, 94% efficacy with 2 doses after 7 days. For long term care facilities residents, 89% efficacy against covid mortality. 97% for >=65 needing homecare.

Also interesting 49% efficacy against all-cause mortality!
Read 5 tweets
3 Jun
CELL-to-CELL transmission that avoids antibodies—a new study shows that once cells are #SARSCoV2 infected, they can infect other cells in ways which are very difficult to inhibit with antibodies. Video shows how virus can move between cells. HT @sigallab.
2) So @sigallab wanted to text if antibodies against #SARSCoV2 can neutralize the virus.

Top row, with virus infection *not via cell to cell*, the more antibodies (left), the less virus leftover.

Bottom row: in cell to cell infection, antibodies made zero difference! 👀
3) The implication? Once the infection sets in, the virus can keep proliferating and transmitting cell to cell, avoiding the blood stream or wherever antibodies can access and directly neutralize the virus. #SARSCoV2 is a tricky beast.
Read 5 tweets
2 Jun
📍STUNNING-Brazil’s @jairbolsonaro apparently intended to lead 🇧🇷 to herd immunity by natural infection, **whatever the consequences**. That means (w/ 1% IFR, 70% herd threshold) by definition he planned for >1.4 mil deaths!

That was the plan!🧵 #COVID19
nytimes.com/2021/05/27/opi…
2) “Here is one example. In March 2020, a social media campaign called “Brazil Can’t Stop” was launched by [Bolsonaro’s] communications unit. Urging people not to change their routines, the campaign claimed “coronavirus deaths among adults & young people are rare.”
3) “The heavily criticized campaign was eventually banned by a federal judge and largely forgotten.
Then the plot thickened. Brazil’s former communications director, Fabio Wajngarten, told the inquiry that he didn’t know “for sure” who had been responsible for the campaign…
Read 23 tweets

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