On this day, in 1981, 5 cases of what came to be known as AIDS, were reported in @CDCMMWR—changing the world.

Today, the Lancet journals reflect on the science and people behind #40YearsOfHIV/AIDS response through a special collection of content ➡️ hubs.li/H0PGLbC0
Months later, Kenneth Hymes et al. published an article in @TheLancet describing Kaposi's sarcoma in a group of young homosexual men in New York, suggesting a sexually transmissible disease might have a role in the pathogenesis of the rare cancer.

Read hubs.li/H0PGMwN0.
In 1984, Philippe Van De Perre et al. and Peter Piot et al. provided early data on #AIDS in Rwanda and Zaire.

Udani Samarasekera talks to Peter, Director of @LSHTM, about the first African research project on AIDS, @UNAIDS, and hopes for the future: hubs.li/H0PGL9f0
Remarkable progress has been made since AIDS was first discovered.

@TheLancetHIV’s latest Editorial tracks #40YearsOfHIV/AIDS response through Lancet articles and reaffirms the Lancet group's commitment to HIV/AIDS.

Read hubs.li/H0PGLbJ0. #LancetHIV40
In the 1980s, messaging around HIV triggered fear and victim blaming. Today, messaging signals ending HIV is possible and people with HIV can live productive lives.

Explore the evolution of public health messaging about HIV in @TheLancetHIV: hubs.li/H0PGQSZ0 #LancetHIV40
For this significant anniversary, @ChrisBeyrer shares a personal account of #40YearsOfHIV/AIDS, from the early cases to the first successful trial, to the persisting challenges of the present day.

Mark this important date—Read hubs.li/H0PGL9n0. #LancetHIV40
Visit our NEW hub, #40YearsOfHIV/AIDS response, featuring:
-Past successes and future challenges
-Views from the frontline
-Commissions and Series
➡️ hubs.li/H0Pqg4K0 #LancetHIV40

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More from @TheLancet

29 May
#ChronicPain affects over 30% of people worldwide and exerts an enormous personal and economic burden.

A new @TheLancet Series on #ChronicPain presents recent findings across specialties, with implications for health care providers and patients: hubs.li/H0PgfvK0

The Series explores 3 types of pain—nociceptive, neuropathic, nociplastic—and the biopsychosocial model of pain—interactions between #chronicpain, biological, psychological, and social factors.

Read an update on burden, best practices, and new advances: hubs.li/H0Pgfv10
Nociplastic pain is a new descriptor of pain arising from abnormal pain signal processing. It applies to a range of conditions, such as fibromyalgia, that lack clear mechanisms or biomarkers—a challenge to diagnose and treat.

Learn more ➡️ hubs.li/H0Pgfv30
Read 6 tweets
28 May
In 2019, the no. of smokers worldwide ⬆️ to 1.1 billion. Tobacco smoking caused ~8 million deaths—1 in 5 male deaths.

#GBD studies of 204 countries highlight the enormous health toll of 🚬 and authors urge all countries to do more to ⬇️ tobacco use. See hubs.ly/H0Pd0590.
89% of smokers began by age 25—evidence suggests an individual is unlikely to become a smoker if they do not start by this age.

Yet over half of countries show no progress in reducing 🚬 among 15-24-year-olds—a critical window to prevent initiation. Read hubs.li/H0Pd09f0.
Why have 🚬 control policies had little impact on young people? They may respond to policies in different ways to adults, writes @aekunst in @TheLancetPH. The solution? Centralising young people's perspectives and experiences. Read hubs.li/H0Pd0YM0.
Read 7 tweets
18 May
NEW—Emerging evidence indicates #COVID19 has distinctive pathophysiological features that set the disease apart from respiratory failure of other origins.

A new 4-part Series in @LancetRespirMed explores COVID-19: Pathophysiology of Acute Disease: hubs.li/H0NyR540
.@osuchm et al. provide a comprehensive Review of the pathophysiology and phenotypes of #COVID19. Read in @LancetRespirMed: hubs.li/H0NySMY0.
The challenges and promise of therapeutically targeting the pleiotropic cytokine interleukin-6 are considered in the 2nd & 3rd papers.

#Interleukin-6: obstacles to targeting a complex cytokine in critical illness—Oliver McElvaney et al: hubs.li/H0NyRjW0 (1/2)
Read 5 tweets
17 May
Cardiovascular disease is responsible for 35% of deaths in women yearly—yet remains:

NEW @TheLancet Commission outlines 10 recommendations to improve health outcomes for millions of women: hubs.li/H0Ns28Y0
275 million women were diagnosed with cardiovascular disease (CVD) in 2019. Acknowledging sex and gender-specific risk factors is the key to understanding #CVD in women and reducing the 🌍 burden.

Read the #LancetWomenCVD Commission: hubs.li/H0Ns28Y0
The global prevalence of cardiovascular disease in women has declined by 4.3% since 1990, but has risen in some of the world's most populated nations—🇨🇳(10%), 🇮🇩(7%), 🇮🇳(3%).

@TheLancet #LancetWomenCVD Commission provides regional recommendations: hubs.li/H0Ns28Y0
Read 5 tweets
26 Mar
Migraine affects over 1 billion people worldwide, is the 2nd leading cause of disability, and a major source of losses to the 🌍 economy—yet professional and political awareness is lacking. Read a new @TheLancet Series on #Migraine by @MessoudAshina et al. hubs.li/H0J-73-0
In 2011, migraine cost Europe an estimated €50-€111 billion. Evidence suggests primary care could meet the needs of most #migraine patients, where available. Read an overview of migraine epidemiology, global burden, and migraine care challenges. hubs.li/H0J-73-0
Migraine diagnosis is based on clinical criteria—criteria that do not capture migraine’s heterogeneity. Read about recent progress in disease characterisation, biomarkers of #migraine, and precision medicine for affected patients: hubs.li/H0J-73-0
Read 4 tweets
24 Mar
63 million lives have been saved since 2000 by global efforts to #EndTB—efforts at risk from #COVID19. Achieving @WHO's #EndTB Strategy targets requires urgent action and investment.

On #WorldTBDay, access related content from across The Lancet titles 👇
Every day, nearly 4000 people die from #tuberculosis. Although considered a public health emergency for over 25 years, only modest progress has been made.

On #WorldTBDay, explore how recent advances could revolutionise #TB control & care in this Seminar: hubs.ly/H0JPlsv0
An estimated 568,000 missing childhood #tuberculosis cases in 2019 were neither diagnosed nor adequately treated. With childhood TB cases on the rise, the case detection gap must be narrowed, writes @Esinofils, @TogunToyin, and @BeateKampmann. Read how: hubs.li/H0JPk5p0
Read 5 tweets

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