.@CMO_England wondering if you can explain why we appear to have a strategy designed to breed a vaccine resistant strain of #COVID19 + why your office is silent on this idiocy?
Large numbers of children infected by Delta, mixing with parents who are partially vaccinated...
1/
Large numbers of children infected by Delta, mixing with parents who are partially vaccinated...
1/
2/ It's easy to see this - and that it's not an artefact from @IanDenton12's charting:
https://twitter.com/IanDenton12/status/1407734030926336008
3/
Any biologist can tell you there will be a variety of viral mutations within an infected person.
By failing to mitigate spread in children, we are selecting for some mutations...
Any biologist can tell you there will be a variety of viral mutations within an infected person.
By failing to mitigate spread in children, we are selecting for some mutations...
4/
When the virus tries to infect a new host, viroids that are blocked by antibodies will not replicate.
But those carrying mutations that are vaccine resistant have a much better chance of taking hold.
When the virus tries to infect a new host, viroids that are blocked by antibodies will not replicate.
But those carrying mutations that are vaccine resistant have a much better chance of taking hold.
5/
Many mutations crop up again and agin.
For example, Delta + carries genes seen in the South African variant that appeared to confer some resistance to vaccines.
We REALLY do not want to select for this mutation.
Many mutations crop up again and agin.
For example, Delta + carries genes seen in the South African variant that appeared to confer some resistance to vaccines.
We REALLY do not want to select for this mutation.
6/
This article from the BBC illustrates the point both tragically and beautifully:
bbc.co.uk/news/world-asi…
As you read it, ask your self how many of these delaying arguments you recognise from when the Kent and Indian variants emerged.
Don't play a drinking game on it...
This article from the BBC illustrates the point both tragically and beautifully:
bbc.co.uk/news/world-asi…
As you read it, ask your self how many of these delaying arguments you recognise from when the Kent and Indian variants emerged.
Don't play a drinking game on it...
7/
...you will get alcohol poisoning.
@CMO_England if your argument is that we cannot jump on every strain consider 2 points:
1. it was argued that transmissibility would be a bigger advantage than evasion. Single data point, but borne out by SA vs Delta variants
...you will get alcohol poisoning.
@CMO_England if your argument is that we cannot jump on every strain consider 2 points:
1. it was argued that transmissibility would be a bigger advantage than evasion. Single data point, but borne out by SA vs Delta variants
8/
2. We have some evidence that the plus mutation shared with the SA strain is at least a little evasive - remember SA ended up abandoning their AZ trial...
2. We have some evidence that the plus mutation shared with the SA strain is at least a little evasive - remember SA ended up abandoning their AZ trial...
9/
We waited to see if the rapidly spreading alpha and delta variants were more transmissible.
Both kicked our butts.
At some point, we really ought to be trying the precautionary principle - especially when a variant presents with circumstantial evidence like A, D and now D+
We waited to see if the rapidly spreading alpha and delta variants were more transmissible.
Both kicked our butts.
At some point, we really ought to be trying the precautionary principle - especially when a variant presents with circumstantial evidence like A, D and now D+
10/
@PHE_uk is still putting out propaganda saying that schools are controlled environments because of social distancing and bubbles.
To borrow from @karamballes, #BubblesAreBollocks
@PHE_uk is still putting out propaganda saying that schools are controlled environments because of social distancing and bubbles.
To borrow from @karamballes, #BubblesAreBollocks
11/
Bubbles only work when there is no mixing between them and our bubbles are porous foam.
Nothing has changed in the 15 months since this video explaining the role of mixing came out:
Bubbles only work when there is no mixing between them and our bubbles are porous foam.
Nothing has changed in the 15 months since this video explaining the role of mixing came out:
12/
Why has Cornwall gone from hero to zero in a few weeks?
Mixing - and only a small fraction of that was G7.
Most of it was people from all over the country heading to one of the most beautiful holiday spots carrying Delta
Why has Cornwall gone from hero to zero in a few weeks?
Mixing - and only a small fraction of that was G7.
Most of it was people from all over the country heading to one of the most beautiful holiday spots carrying Delta
13/
Back to the point though...
If we want to minimise disruption now, face coverings urgently need to be reintroduced into schools and we need to move away from abandoning contact isolation.
Back to the point though...
If we want to minimise disruption now, face coverings urgently need to be reintroduced into schools and we need to move away from abandoning contact isolation.
14/
If we don't then we keep on pumping virus towards the partially immunised and risk escape
And for what?
Face covering help and no one has yet shown me any evidence of their use having significant adverse effects in the many countries they are used
If we don't then we keep on pumping virus towards the partially immunised and risk escape
And for what?
Face covering help and no one has yet shown me any evidence of their use having significant adverse effects in the many countries they are used
15/
If we want to avoid the corrosive disruption to education continuing into the autumn and on further:
- investment in ventilation is urgently needed over the summer
- vaccination is needed in children; if we breed a resistant strain we go back to square 1
If we want to avoid the corrosive disruption to education continuing into the autumn and on further:
- investment in ventilation is urgently needed over the summer
- vaccination is needed in children; if we breed a resistant strain we go back to square 1
16/
Finally we REALLY need to pull our finger out on manufacturing.
We are more than a year on and the Advanced Vaccine Manufacturing Centre does not seem to have opened...
Where is other investment in bolstering production capabilities?
Finally we REALLY need to pull our finger out on manufacturing.
We are more than a year on and the Advanced Vaccine Manufacturing Centre does not seem to have opened...
Where is other investment in bolstering production capabilities?
17/
We may be able to tweak vaccines, but @CMO_England you are walking down a dead end unless something is done about the bottle neck in production and finishing
A few weeks to change the formulation...
...but we are 7 months on from introduction and still supply constrained
We may be able to tweak vaccines, but @CMO_England you are walking down a dead end unless something is done about the bottle neck in production and finishing
A few weeks to change the formulation...
...but we are 7 months on from introduction and still supply constrained
18/
If no tweaks needed, extra capacity can be used to help other countries and then facilitate the treatments (such as for cancer) that MRNA tech was originally designed for
If no tweaks needed, extra capacity can be used to help other countries and then facilitate the treatments (such as for cancer) that MRNA tech was originally designed for
19/
@CMO_England you hold a public office and have a duty to the population, not your political paymasters.
Your voice should be heard.
/end
@CMO_England you hold a public office and have a duty to the population, not your political paymasters.
Your voice should be heard.
/end
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