1/ Following a barrage of Twitter abuse because of my quote about our School Infection Survey (SIS) results today, I would like to reiterate what we have learnt about #COVID19 after 9 million students returned to full-time in-person education in England in March this year 👇
2/ The UK went into national lockdown including school closures in Jan 2021 following emergence of the Alpha variant. #COVID19 cases declined rapidly & schools reopened fully on 08 Mar 2021 (wk 10) when the rest of England remained in lockdown 👉 gov.uk/government/sta…
3/ During the 3 weeks until Easter holidays (wks 10-13, black circle), we saw a small ⬆️ in #covid19 cases among primary school kids (red line) & (because of mass rapid antigen testing before schools reopening) a large short-lived spike in secondary school kids (green) 👇
4/ Note, however, that the overall trend remained downwards including in the adult age-groups & remained *low & flat* for 6 whole weeks after the Easter break when all students returned to school while adults were in lockdown (blue circle). Cases did not ⬆️ in kids or adults 👇
5/ But look what happened when we moved into step 3 easing (17 May) of national lockdown (red circle). Cases started to ⬆️ in adults & kids, especially university-age (18-21y) & 20-29 yr-olds. Note the identical upward trajectory in secondary school students & 20-29 yr-olds 👇
6/ If this increase in cases after 17 May 2021 was school-related, then it should have started in April & cases should have transmitted to adult age groups in the household & in the local community, but we didn’t see any of that.
7/ And when you look at the national community infection survey (ONS CIS) which screens households across England, how can one explain such low infection rates in primary & secondary school students until 13 June, even after they were attending school full-time for >6 weeks?👇
8/ To me at least, the similar trajectory between secondary school students & 20-29 year-olds would suggested common contact & social behaviors outside school after 17 May when England started opening up, allowing youngsters more opportunities to meet & gather outside school
9/ Clearly, these data do not differentiate between in-school & outside-school transmission, but the published literature all point to limited [Not Zero, but low] in-school transmission, most likely because of the mitigations placed in schools [however well or poorly implemented]
10/ In conclusion, my reading of the data indicates that cases & outbreaks in schools reflect what is happening in the local community & with nearly all adults nearly double vaccinated, hopefully community infections rates will ⬇️ & that should help keep schools open more safely
10/ PS. Yes: we need more support for mitigations, including ventilation; No: I still haven’t seen convincing data on how much masks help ⬇️ school transmission; & No: we don’t need another adult lockdown to reopen schools because adults are now vaccinated (you know who you are)

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More from @ShamezLadhani

9 Aug
1/ There have been increasing claims, mainly in North American news outlets, that the #SARSCoV2 DELTA variant is causing more severe #COVID19 in kids compared to previous variants

Well, everything we know so far indicates that’s it’s *not* true. Here’s why…🧵
2/ It’s true that the delta variant is more transmissible the both the alpha variant & the original strains, which means that it will infect more people more quickly, but there is no evidence that the risk of infection or transmission to others is different in kids vs adults
3/ Because of its higher transmissibility, there will be more Delta variant cases &, since most adults in many countries are vaccinated against #COVID19, cases/hospitalisations may seem disproportionately ⬆️ in kids (especially teens) vs adults. This just shows that #VaccinesWork
Read 13 tweets
7 Aug
1/ It’s actually headline-grabbing news articles such as this that fuel conspiracy theories

The JCVI did not make a U-turn on vaccinating teens. The JCVI path to vaccinating teens has remained the same & their message has been consistent. Here’s why 🧵

👉thetimes.co.uk/article/when-v…
2/ On 19 July 2021, JCVI issued advice on COVID-19 vaccination for teenagers

JCVI advised that those aged 12+ years with specific underlying health conditions that put them at risk of serious COVID-19 should be offered COVID-19 vaccination

👉 gov.uk/government/pub…
3/ For healthy teens, however, JCVI *deferred* the decision, specifically stating “Data on the incidence of these events [myocarditis in teens & young adults] are currently limited, & the longer-term health effects from the myocarditis events reported are not yet well understood”
Read 10 tweets
31 Jul
1/ Our preprint on #SARSCoV2 infection & transmission in secondary schools following the emergence of the Alpha variant in England is now online

We took multiple blood samples from ~2,000 students/staff for #SARSCoV2 antibodies. Here’s what we found 🧵

👉medrxiv.org/content/10.110…
2/ In England, #Covid19 cases due to the Alpha variant increased rapidly from late Nov 2020, leading to national lockdown in Dec 2020, including school closures. When schools reopened fully in Mar 2021, we took blood samples from 1,895 students & staff in our sKIDsPLUS study
3/ Between December 2020 & March 2021, 5.6% (61/1094) students & 4.4% (35/792) staff had laboratory-confirmed SARS-CoV-2 infection.

Most of these infections were acquired during community peaks in infections rates in December 2020, with a trickle of cases throughout lockdown
Read 8 tweets
29 Jul
1/ It was the JCVI that used basic immunological principles of vaccination to recommend a 12-week interval between #COVID19 vaccines to save more lives during the Alpha wave in the UK

Our paper (preprint) here shows why that was the right decision…🧵

👉medrxiv.org/content/10.110…
2/ We tested #SARSCoV2 antibodies in adults aged 50-89 years and found that, for both Pfizer & AZ vaccines, 95% had seroconverted (developed antibodies) by 35-55 days after the first #COVID19 dose, and 100% by 7+ days after the second dose

👉 medrxiv.org/content/10.110…
3/ BUT, when the vaccines were given 9-11 weeks apart, antibody levels at 2-5 weeks after 2nd dose were 6x ⬆️ for Pfizer (6703; 95%CI, 5887-7633) than AZ (1093; 806-1483), which in turn were higher than Pfizer given 3-4 weeks apart (694; 540 - 893) 👉medrxiv.org/content/10.110…
Read 6 tweets
27 Jul
1/ On 19 July 2021, JCVI published their statement on #Covid19 vaccination for 12-17 yr-olds

If you only heard that JVCI did not recommend vaccine for teens then you missed out on a wealth of information & recommendations in the report

Here’s why 🧵

👉 gov.uk/government/pub…
2/ First, the MHRA & JCVI have very different functions. The MHRA authorises medicines, including vaccines, & monitors their safety but does not make vaccine recommendations. The JCVI makes recommendations on vaccines for the national immunisation programme & for risk groups
3/ JCVI took rather long to release their statement on vaccinating 12-17 yr-olds because risk-benefits of vaccinating this age-gp
were finely balanced between risk of severe #Covid19 & risk of rare but severe side-effects for the only vaccine licensed for 12-15 yr-olds (Pfizer)
Read 19 tweets
21 Jul
1. Most of us do not really appreciate how resilient children and their immune systems are when they encounter #sarscov2. Most kids don’t even realize they have been exposed, which leads to ⬆️⬆️⬆️ over-estimation of the long-term effects of #COVID19 in children

Here’s why … 🧵
2/ when asked, most parents don’t even realize when they child was exposed to #SARS_CoV_2 because most kids either remain asymptomatic or have such a mild and transient illness that parents don’t even associate the illness with #COVID19
3/ In our primary schools study, although small numbers, parents reported no symptoms in 85% of kids who didn’t have #SARS_CoV_2 antibodies at start of the study & then developed antibodies during the study (ie. got infected) compared to 47% of staff
👉 thelancet.com/journals/lanch…
Read 7 tweets

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