All the focus is on #Kerala's #COVID19 cases as it contributed ~68% of new cases in India y'day.

Politically, it's become a major tool of attack against the state & its government.

This thread tries to make some sense of the COVID19 numbers from Kerala.

1/
Many are asking why Kerala is reporting so many cases while the rest of India seems to have flattened it.

Yet, I'm actually surprised why Kerala is reporting only so many cases when it should be actually reporting 40K+ daily cases already.

2/
The current rise in cases was inevitable with the somewhat irrational lockdown relaxations & increased mobility that is visible over the past several weeks. It is only the reduced testing that is still holding the reported cases well below 40K.


3/
The TPR was under control & steady at around 12% till about Aug 3. Since then, we have been seeing a steady decline in testing, followed by a marginal decrease in cases but rising TPR. The fall in cases was definitely not organic during this time.

4/
7'day avg. daily testing had decreased from 1.7L to 1L leading up to #Onam2021 on Aug 21 as the avg. TPR went up from 12% to 17%. Tests were increased to 1.65L y'day which also saw a sudden rise in reported cases with a TPR of 19%.
5/
If #Kerala did at least 2L tests now it must be reporting ~40K cases already. The state had shown the capacity to do 2L tests on multiple days late Jul/early Aug. With TPR close to 19%, it's obvious that current reported cases are missing out on a lot of actual cases.

6/
Important questions remain.
❓Why state is still reporting a huge number of cases?
❓Is it a new variant?
❓Is it the beginning of a 3rd wave?
❓Will it collapse Kerala's healthcare system as it occurred in many other states?

I have my own answers for each.
7/
Why state is still reporting a huge number of cases?

The below article I had written gives a reasonable explanation & most of it still holds.

Bottom line: #Kerala still has the highest proportion of the population with no COVID19 antibodies in India.

8/
Is it a new variant?

No. Close to 90% of the samples in Kerala are still Delta variant, a variant that was the primary reason for the majority of cases during the 2nd wave in rest of India.

#Delta is still catching up in the Kerala population.
9/
Is it the beginning of a 3rd wave?

I do not think so. Delta varient-led 2nd wave in India did not come from Kerala. Unless Kerala's current rise in cases is from a new variant (which is not the case), there is no reason to panic that this will lead to a 3rd wave.
10/
Will it collapse Kerala's healthcare system?

#Kerala's healthcare system was nearly saturated (but not collapsed) during the 2nd wave peak when it was reporting 40K cases with 28% TPR.

I expect it'll reach the same in coming days & the authorities must be prepared for it.

11/
Avg. reported deaths had reached 191/day, 3 weeks after the 2nd wave peak. The current avg. is 131/day.

With cases expected to cross 40K, the deaths may increase in the coming days too. But, vaccinations may be a saviour this time around.

12/
#Kerala has already vaccinated 75% of its adult population with at least a single dose (one of the highest in India).

55% of its entire population has received at least a single dose, again one of the highest.

This may be a saving grace this time in terms of fatalities.

13/
While the capacity is nearing saturation in some districts, it's not yet in a panic situation with sufficient capacity still remaining overall.

But, it's time to be highly conscious of the situation ahead.
14/
It may be a wise decision to go in for a complete lockdown now for a week or two to arrest a sudden surge & spread the cases over a longer period to minimize the load on the healthcare system as it used to do in the past.

Take vaccinations at full speed during this time.

15/
I believe the current surge will slow down in a week or so &, by then, the natural infection & vaccinations would've taken the population-level COVID19 immunity in Kerala to 60% to 70% level bringing it closer to the rest of India, but with much less human toll.

16/
However, what is important is to make sure not to overcrowd the healthcare system, increase vaccination pace, increase testing & tracing keeping an eye on TPR so we don't lose identifying too many cases.

Kerala must soon consider a short duration full lockdown.

17/

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More from @RijoMJohn

4 Aug
Prof. @MenonBioPhysics, @nebuer42, & I prepared a set of recommendations on #Kerala's #COVID19 management, part of which was appeared in today's @Malayla_Manoram.

It pertains to suggested changes in the current lockdown policy of the state, vaccinations, etc.
1/
Recommendations on lockdown.
2/
Recommendations on vaccination.
3/
Read 4 tweets
30 Jul
This thread on why #Kerala’s #COVID19 numbers still not falling & my subsequent tweet on ICMR 4th serosurvey has exponentially increased the level of troll activity on my TL

I love data & let me dispel more misconceptions with data so the trolls can keep earning their bread.
1/
First of all, I feel pity for these trolls wasting their time on a state whose healthcare infra has never collapsed at any time during this pandemic.

Here's the current usage of health infra in Kerala. Don't you worry, the state will sail through even at 40K daily cases.
2/
One major argument against my original thread was that I used an old ICMR serosurvey. Yes, because a new one was not yet available. When it became available, it didn't change a thing. See the article I wrote deriving same conclusions using 4th survey.
3/
science.thewire.in/health/why-is-…
Read 14 tweets
24 Jul
Seroprevalence in #Kerala is 42.7% compared to 67.6% as per the note shared byGovt. of Kerala y'day. i.e., a difference of 25% points.

It implies, the pandemic spread in Kerala has stayed consistently well below the national avg. indicating a more flattened curve in Kerala.
1/
Both 7-day avg. daily new cases & test positivity rates are on a steady rise in #Kerala as ~50% of the popn still remain susceptible.

Daily testing has been stable around 1.3L/day

The state needs to significantly increase its daily testing given the high & increasing TPR
2/
Although the daily reported deaths have declined a bit, the mortality rate itself has been on the rise.

At 0.5%, it is higher than the previous wave.
3/
Read 6 tweets
22 Jul
.@MoHFW_INDIA has quickly come up with another #MythsVsFacts to "debunk" one more report highlighting India's #COVID19 deaths undercounting as they've done multiple times in the past.

As usual, the rebuttal itself is rich in myths & low on facts.
1/
The original study by the @CGDev & authored by respected authors including Dr. @arvindsubraman, former chief economist to GoI, estimates that India may have undercounted #COVID19 deaths by 10 times. The study can be found here.
2/
cgdev.org/publication/th…
The major problem GoI seems to have is that this study "audacious"ly assumed the same international estimates of age-specific infection fatality rates (IFR) to Indian seroprevalence data ignoring the fact that the authors have used 3 different methods to derive their numbers.
3/
Read 19 tweets
18 Jul
Has #Kerala miserably failed in containing #COVID19 pandemic?

This is a question I keep getting from various quarters. This thread is an attempt to explain it.
1/ Image
Using the latest ICMR 3rd sero survey results during Dec 2020, we can see that #Kerala was able to identify & report one in every 5 cases, while all of India was able to identify only 1 in every 28 cases.

It shows the effectiveness of testing strategy used in Kerala
2/ Image
Testing after good tracing & tracking would make it much more effective. This may result in higher TPR, but it's a cost effective use of testing infrastructure

Kerala has not only done nearly double the number of tests per million but it had a much better case detection rate.
3/
Read 13 tweets
12 Jun
Thread.

1/ An article from @TheEconomist claiming that India's true #covid19 mortality maybe 5-7 times than the reported numbers has really irked GoI so much so @MoHFW_INDIA has now published a rebuttal that is short on substance but abundant on rhetoric.
2/ After using words like "speculative", "misinformed", "unsound" etc. to describe the article, the rebuttal interestingly says "there is no peer-reviewed scientific data available" for some studies used in that report.

I'm glad GoI takes scientific peer review seriously.
3/ Then why has it made claims on the safety & effectiveness of Covaxin without backing up with peer-reviewed scientific data?

What was the peer-reviewed scientific data based on which #Coronil got Ayush Ministry certification?

Thi list is actually long. So, I'll stop.
Read 15 tweets

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