Thread by @marija_backovic

I've been eagerly waiting to see this type of #VE comparison that includes #Sinopharm #SputnikV #PfizerBNTech.
Thanks to the study conducted in Bahrain by @DrSidMukherjee & colleagues abroad, many of the gaps in current knowledge have been filled 👇 (1/n)
researchsquare.com/article/rs-828…

This is particularly important for LMIC that have relied heavily on #Sinopharm administration, and while the @WHO approved this vaccine, the VE data for adults >60 yo have been missing. Now we have the comparison that clearly shows two things (2/n)

1. The 3 vaccines provide significant protection against infection, hospitalization, ICU admission and death. This is great, and it means, as expected, that the #VaccinesWork.

2. The 3 vaccines are not made equal. This means that the level of protection is not the same. (3/n)

Look at the comparison between #Sinopharm and #PfizerBNTech VE in different categories, and in particular for adults > 50 yo. #Pfizer vaccine over-performs #Sinopharm in all the categories: infection, and more importantly hospitalization, ICU and death. (4/n)

Then look at the comparison between unvaccinated people and people who received #Sinopharm. It is clear that the prognosis and chance of getting sick is way much better for the vaccinated individuals. So #Sinopharm works. (5/n)

Why am I writing all this then? It is because many LMIC, like #Montenegro, used #Sinopharm to vaccinate the most vulnerable population that had the priority because #Sinopharm was the vaccine that was available and could be obtained the fastest (6/n)

Now, some 6-8 months later these same vaccinated but vulnerable individuals have the least protection. With #delta raging around this is a problem. They will certainly do better than the unvaccinated group of the same age, BUT some will get very sick and some will die. (7/n)

What I'm advocating for is that this information is taken into account when making national strategies for 3rd dose boosts in LMIC, and that vulnerable groups that had previously received #Sinopharm - if possible - have a priority to get #Pfizer @ijzcg @MinZdravlja @VladaCG (8/n)

p.s. I left #SputnikV aside, but in a nutshell it performs better than #Sinopharm and worse than #Pfizer. You can find the entire set of results here. Enjoy the reading! researchsquare.com/article/rs-828…. (n/n)

@threadreaderapp please unroll