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Laurie Garrett Profile picture
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17 Sep, 12 tweets, 11 min read
Hearings today @US_FDA on @pfizer application to give 3rd doses of #COID19 #vaccines . Much rests on the Israeli findings. Two reps of their MOH presented details, which are significant because Israel's mass vax is abt 3 months ahead of Europe & UK & USA.
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2/ Israel 1st rolled out mass vax in December, and the impact against routine forms of #COVID19 was excellent. It seemed that a standard @pfizer #vaccine protocol worked beautifully.
BUT, MORE
3/ But then, Israelis told @US_FDA , the #DeltaVariant slammed Israel and #COVID19 incidence in all age groups, including among fully vaccinated, soared. The question was why.
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4/ The soar in #COVID19 incidence after 2-dose vaccination in Israel could have been caused directly by #DeltaVariant or cld mean the @pfizer #vaccine protection was waning, weakening.
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5/ It was urgent that Israel figure out why #COVID19 was soaring despite mass 2-dose vaccination, because projections showed that by Sept., if unabated, the epidemic would overwhelm the nation's medical capacity. If waning immunity was key, a 3rd dose might stop it.
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6/ The Israelis were convinced that the efficacy of the @pfizer #vaccine was waning over time, especially in people over 60 years of age. They felt there was a clear decrease 6 mos after full vax.
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7/ So in July Israel started a mass 3rd-dose vax campaign, initially targeting the >60 yr old population. This chart shows levels of protection against #COVID19 infection, starting on the left w/only 2 doses & then weeks after 3rd dose.
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8/ The 3rd dose ushered a bug drop in #COVID19 hospitalization rates in >60 yr olds. TEN-FOLD decline.
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9/ The incidence of new #SARSCoV2 infections plummeted after 3rd dose administration to Israelis >60 yrs of age.
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10/ As the Israelis lowered the ages on people targeted with 3rd doses of @pfizer #COVID19 #vaccine they saw an impact on the epidemic overall -- the reproductive rate (Ro) dropped radically, they told science advisors to @US_FDA this morning.
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11/ The Israelis told the @US_FDA mtg this morning that the overall impact on Israeli society of widespread use of a 3rd dose of @pfizer #COVID19 #vaccine has been dramatic.
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12/ This summarizes Israel's analysis of 3-dose #COVID19 immunization with the @pfizer #vaccine.
The @US_FDA scientific advisory board is meeting all day. Stay tuned.

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More from @Laurie_Garrett

Laurie Garrett Profile picture
17 Sep
Big news from Laos @PasteurVirology relevant to the origins of #SARSCoV2:
"our results pinpoint the presence of new bat sarbecoviruses that seem to have the same
potential for infecting humans as early strains of SARS-CoV-2."
MORE

researchsquare.com/article/rs-871…
2/
 "People working in caves, such as guano
collectors, or certain ascetic religious communities who spend time in or very close to caves, as well as
tourists who visit the caves, are particularly at risk of being exposed. Further investigations are needed to
assess..."
MORE
3/
 "...if such exposed populations have been infected by one of these viruses, if these infections are
assoc'ed w/symptoms, & whether they could confer protection against subsequent #SARSCoV2
infections."
AND, they found, "sequences very close to
those of the early..."
MORE
Read 8 tweets
Laurie Garrett Profile picture
17 Sep
In today's hearing @US_FDA on @pfizer request for approval of 3rd #COVID19 #booster #vaccine the company presented data on its original 2020 study volunteers, many of whom originally got placebos. All those people were eventually given 2 doses of vax, but months after the..
MORE
2/...matched study pool that was vaxed from the start. This created a staggered time set for looking at duration of immunity, and then comparing impact of giving all of them a 3rd dose. They looked at protection against original (WT) form of #SARSCoV2 & beta (SoAfrica) type.
MORE
3/ The @pfizer conclusion is that #vaccine efficacy definitely wanes over time, a 3rd dose works to boost it, said dose is safe and powerful. Company said 1.8 million more cases of severe #COVID19 wld occur in USA this year w/out 3rd dosing.
MORE
Read 5 tweets
Laurie Garrett Profile picture
17 Sep
Scientific advisors @US_FDA are meeting today to decide whether @pfizer 3rd dose #COVID19 #vaccine booster should be approved. Sarah Oliver started, from @CDCgov , laying out grim current epidemic situation in USA.
MORE
2/
 the @CDCgov Oliver showed that there was a tremendous uptake of #COVID19 #Vaccination in the USA in April, which plummeted by June and is crawling back now. Overall, vaccine uptake is the paramount problem.
MORE
3/ Because #COVID19 #vaccination rates in America remain disappointing, COVID hospitalizations are soaring. And unvax'ed people under 65 are 22 to 23 TIMES more likely to be hospitalized versus those who have received vaccines. The difference is astonishingly huge.
MORE
Read 7 tweets
Laurie Garrett Profile picture
6 Sep
OK, ENOUGH ALREADY.
Here's the #Ivermectin saga, people.
1.) In the 1960s Japan's Satoshi Omura did chemistry work, trying to find a medicine to kill helminth worms in livestock.
2.) In the '70s he joined forces with Max Tischler at Wesleyan in USA.
3.) They brought...
MORE
Iver/2/
...@Merck & @Kitasato pharma companies on board.
4.) Omura discovered a bacterium that emitted a powerful anti-helminth chemical.
5.) William Campbell @Merck tested it. Using synthetic chemistry, they made "ivermectin" -- 25Xs stronger than the bacterial chemical.
MORE Image
Iver/3/
5.) The @Merck & Kitasato companies were thrilled to discover it cured a long list of livestock worm & parasitic diseases & a huge veterinary market opened.
6.) In 1981 Bangladeshi Mohamad Aziz showed that #Ivermectin could cure River Blindness, a terrible disease...
MORE Image
Read 17 tweets
Laurie Garrett Profile picture
6 Sep
ICYMI 3 excellent graphics from @TheEconomist comparing immune responses with & w/out #vaccines to alpha vs #DeltaVariant #SARSCoV2.
First, efficacy dropped in UK for both @AstraZeneca & @pfizer vaxes against Delta, once it took over the #COVID19 landscape.
MORE
2/ When the UK switched from alpha #SARSCoV2 to the #DeltaVariant dominating the #COVID19 landscape, the key change was in the ability of @AstraZeneca or @pfizer vaccines to prevent infection.
MORE
3/ Curiously, in the UK when UNvaccinated folks got re-infected with alpha #SARSCoV2 they mustered weak antibody responses, despite prior exposure. But with #DeltaVariant a 2nd infection in unvax'ed people elicited a BIG antibody response. Why? Who knows? Merits study.
MORE
Read 4 tweets
Laurie Garrett Profile picture
27 Aug
Many #COVID19 #vaccine refusers say there's "something" in there -- a transmitter @BillGates uses to monitor us, magnets, 5G signalers.
Let's take a look:
1.) Whatever "it" is must be small enough to pass thru a 0.152 mm (aka 0.0035 inch) wide hole at the tip of vax needle.
MORE
2.) It must be powered somehow.
3.) and it should last a long time to be worth the cost & trouble.
So, how does that stack up with reality?
World's smallest battery is 150 nanometers, but doesn't last long -- minutes. Tiny 3.5 mm lithium batteries work, but that FAR too big.
MORE
World's smallest transmitter is 5 by 9 by 4.8 mm in size, transmits up to 120 meters, requires a 1.5V battery.
Too big.
Smallest Bluetooth transmitter runs on 0.6 milliwatt battery but needs a 14 mm antenna.
Too big.
And any transmitter needs a microphone --
MORE
Read 6 tweets

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