1/ Household transmission of #SARSCoV2 in children & adults
This new @PHE_uk study was pre-Alpha, pre-Delta & pre-vaccine but provides important insight into household infection & transmission risks in kids & adults
Here’s what the study found … 🧵
👉 journalofinfection.com/article/S0163-…
This new @PHE_uk study was pre-Alpha, pre-Delta & pre-vaccine but provides important insight into household infection & transmission risks in kids & adults
Here’s what the study found … 🧵
👉 journalofinfection.com/article/S0163-…
2/ The study followed up 452 household members of 181 PCR-confirmed adult & child cases in England during Mar-Nov 2020.
Nasal swabs taken for #SARSCoV2 PCR at baseline & Day 7.
#SARSCoV2 Antibodies tested at baseline & Day 35 to detect symptomatic + asymptomatic infection
Nasal swabs taken for #SARSCoV2 PCR at baseline & Day 7.
#SARSCoV2 Antibodies tested at baseline & Day 35 to detect symptomatic + asymptomatic infection
3/ 91/431 (21%) contacts were PCR +ve & 180/383 (47%) were antibody +ve at day 35 👉 194/431 (45%) contacts had PCR +/- antibody evidence of infection
After excluding 55 households with prior/co-primary cases & PCR -ve asymptomatic contacts, 75/248 *(33%)* contacts were infected
After excluding 55 households with prior/co-primary cases & PCR -ve asymptomatic contacts, 75/248 *(33%)* contacts were infected
4/ There was an inverse relationship between household size & transmission rate (bigger household ➡️ lower transmission)
Secondary Attack Rates in contacts was 16% for 0-10 yr-old children but doubled to 33% in 11-18 year-olds, 36% in 19-54 year-olds & 32% in 55+ year-olds
Secondary Attack Rates in contacts was 16% for 0-10 yr-old children but doubled to 33% in 11-18 year-olds, 36% in 19-54 year-olds & 32% in 55+ year-olds
5/ Contacts in households where index cases reported that they were isolating from other members did not experience a lower attack rate
BUT attack rates from index cases with respiratory or systemic symptoms were significantly higher than in those without such symptoms.
BUT attack rates from index cases with respiratory or systemic symptoms were significantly higher than in those without such symptoms.
6/ The proportion infected who developed symptoms (78%) was similar by age (p = 0.44) though 0-18 year-olds had fewer mean number of symptoms than adults (p = 0.001) and fewer reported loss of sense of taste or smell (p = 0.0001).
8/ Having at least 1 symptom needed for community testing (fever, cough, taste/smell loss) had sensitivity of 73% & captured 132/153 (86%) symptomatic infected contacts. But 32% (64/203) contacts without serological evidence of infection also reported at least 1 of these symptoms
7/ Conclusion: Risk if #SARSCoV2 transmission in the household is high, even when the infection is introduced by a child.
The risk of young children acquiring #SARSCoV2 infection was lower than that in adults and fewer kids developed typical symptoms of Covid-19 infection
End
The risk of young children acquiring #SARSCoV2 infection was lower than that in adults and fewer kids developed typical symptoms of Covid-19 infection
End
• • •
Missing some Tweet in this thread? You can try to
force a refresh
