See talks sleep disruptions and fatigue: sleep disruptions cause issues with brain function, metabolism, increase oxidative stress, and inflammation. #fatigue (1/5)
See talks sleep disruptions and fatigue: sleep disruptions cause issues with brain function, metabolism, increase oxidative stress, and inflammation. #fatigue (2/5)
Interestingly, fatigue and sleepiness are not necessarily even related. It’s refreshing to see these ideas teased apart. Feeling sleepy =/ fatigue as a symptom of disease. #fatigue (3/5)
Interesting: someone with insomnia describes “wired but tired” … ‘exhausted but also like I’ve mainlined coffee’. Curious, #pwME and with #LongCovid … how many of you have sleep issues (insomnia, disturbed sleep, inverted or chaotic rhythm)? #fatigue (4/5)
”in a sleep clinic, if you’re not sleepy then we would say that you have fatigue. But we don’t measure fatigue. I would argue it’s important to differentiate.” (5/5)
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Now we get to another area of particular interest for me: circadian rhythms and #fatigue. Elizabeth Klerman presenting. (1/5) #sleep
How does sleep/circadian rhythms affect various body systems and ultimate effects?
First I've heard of health disparities, here; well done, Klerman. #fatigue#sleep
Circadian rhythms WILL affect results in studies. Researchers, take note!
Record time of events, blood draws, etc.!
Include sleep metrics in subjects!
Circadian =/ diurnal.
Most studies that say they're talking about circadian rhythms are actually referencing diurnal rhythms.
Dragana Ragulja reports: what actually is cause of death in sleep deprivation?
Loss of life in test animals on Day 10 of sleep deprivation led to dissection and finding of serious increases in ROS in the gut in particular (1/3)
Antioxidants specific to the gut can 'rescue' the animals tho. (2/3)
Takeaways: 1) Sleep deprivation is a "bodywide phenomenon", says Ragulja. 2) Not all lack of sleep is created equal. Feelings of sleepiness can be blocked even though it's still fatal. "The fact that you feel fine on four hours of sleep does not mean you actually are fine." (3/3)
ooooh, I am very interested in this! Pierre Magistretti is discussing the astrocyte-neuron lactate shuttle. I had a long conversation with someone who wrote a review paper on this one. (1/6) #fatigue#neurology
Lactate is required for energy for the brain. BUT -- it is not only this but also a signalling molecule for neuroplasticity & neuroprotection. (This idea of lactate being 'neuroprotective' is of particular interest to me.) (2/6) #fatigue#neurologypubmed.ncbi.nlm.nih.gov/21376239/
Magistretti is going at warp speed on this one, and I would have no idea what he was talking about if I hadn't already familiarized myself with the astrocyte-neuron lactate shuttle. However, he is clearly unfamiliar with #MECFS. (3/6) #fatigue#neurology
Now we're up to Ron Davis and the metabolic trap hypothesis for #MECFS: yeast model for the metabolic trap. (1/7) #metabolism#fatigue
Tryptophan is largely metabolized by a protein made by an enzyme called IDO-1. A second enzyme, called IDO-2, may be a "more primitive" version of the same enzyme. IDO-1 is substrate-inhibited. (2/7) #metabolism#MECFS
In a small study with ~20 severe patients, all had at least one mutation in IDO-2. "It's not a requirement that you have a mutation in IDO-2" to have ME/CFS, says Davis. It doesn't rule out that mutations here can play a role. (3/7) #metabolism#MECFS
Mark Davis now. He's talking about celiac (severe gluten intolerance/sensitivity). He found that gluten-specific CD4+ T cells were directly associated with the response. (1/6) #fatigue#celiac#autoimmunity
Interestingly, they're mentioning elevated KIR+ CD8+ cells in autoimmunity. KIR is typically thought of as a marker for NKCs, & associated with their maturation (me saying this, not M Davis). Intriguing, then, that KIR+ CD8+ cells are associated w/autoimmunity... (2/6) #fatigue
...when decreased function of NKCs is associated with ME/CFS. Moreover, perforin (a compound created by NKCs and often a way of measuring their functionality) (3/6) #MECFS#immunology#fatigue
Ian Lipkin, now: Lipkin is summarizing a number of different efforts associated with his research group. He is the first person at this conference that has mentioned how previous coronaviral outbreaks (SARS/MERS) have led to ME/CFS-like syndromes. (1/7) #LongCOVID#MEcfs#GWI
Talking about work at Centers, with shout-outs to each center as well as the nonprofits that have been involved, including our own @MEActNet. (Looking forward to sharing stuff re: this project soon!) (2/7) #MEcfs@Columbia_CII
Overall aims for the Collaborative Research Centers, funded by @NIH. (3/7) #fatigue#MEcfs