The posts from what we know in the last 3 days across the globe on #Omicron are all at one place here. Feel free to read along . The information from 29th November will follow in the thread below .Currently this is the known Geographic spread #RPSMTrust
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Ctd1) So there is a concern that the #Omicron is diversifying pretty fast, that concern in a population where 20% has HIV is a legitimate issue
Ctd2) All Variants of Concern have such clusters of sudden increase of mutations,the issue is they are coming up in an area where only 70% get access to Antiretroviral (HIV Tt) therapy,help needs to go a further step ahead - covid vaccines, antiretrovirals,logistics& Monoclonals
Ctd3) @michaelmina_lab tells us that the waste water surveillance is showing that the virus is spreading like crazy , that reminds me of what happened in Brazil after the P1 wave ended, they almost immediately had the P2 wave , this looks like a familiar story ctd) ImageImage
Ctd4 Japan closes borders to all foreigners.
Ctd5)Marriage of the Two pictures one of the provinces and the second of the percentage people positive shows that while the positive population is highest in Gauteng BUT it is also rapidly growing in the southern states , north of Gauteng the growth is not as much @DrEricDing ImageImage
Ctd6) WHO update- not much new information but still who.int/news/item/28-1…
Ctd7) @Antonio_Caramia made a good chart of cases & these have grown at astronomical rates, almost 6 times in last 2-3 weeks , we know that if cases rise hospitalizations & deaths rise in 4 to 6 weeks later .They will overwhelm hospitals .We know 18% infected need hospitals. Image
Ctd9) Yesteray We had updated that we expect that the RTPCR will work out fine ( if not better) and @michaelmina_lab had said he expected the Lateral Flow ( Rapid Tests ) would've been fine, here is more information that they are working Image
Ctd10) @davidrliu clearly shows the rate of change in spike protein and since Moderna /AZ /Pfizer all work at the spike protein there's fair chance that they MAY take a hit( so many mutations there).Oral medications like Paxlovid, Molnupiravir may not take that big a hit ctd) Image
@davidrliu Ctd11) Meanwhile Australia finds one more Image
@davidrliu Ctd12) #Omicron has been found in Europe ,Australia& North America ,Africans are wanting not be discriminated against, wishing the world community come together & stop global air travel for 3 weeks .WHO leaders @DrMikeRyan, @DrTedros ctd)

@PMOIndia
Ctd13) Image
Ctd14) Image
Ctd15) Image
Ctd16)AstraZeneca Vaccine in India, need to boost old and frontline workers @PMOIndia , @narendramodi , @shekhar_mande , @MoHFW_INDIA , @BhallaAjay26 ,@OfficeOf_MM , @mansukhmandviya Image
Ctd17)Community transmission found in Scotland. That shows the need to act fast, test & track immediately. Image
Ctd18)Now comes Portugal , Europe will soon find #Omicron all over if they don't act fast . Image
Ctd19) @hjelle_brian created a flutter when he noted that TMEM245 is a snatched human protein, @PeacockFlu ,@SGriffin_Lab ,@ChristosArgyrop . Months earlier I had read this . Is TMEM245 an alternative entry pathway #Omicron
piecehttps://www.eurekalert.org/news-releases/651439 Image

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More from @Rpshahmemorial1

30 Nov
Long thread - The Nov 29th post & the information is all here below in the link posted and after that will be the updates for today ie 30th November@emilygraymd_mph ,@rubyslippahs,@GANyborg ,please add information that may have been missed @itosettiMD_MBA
Ctd1) A summary of what we know new about the current #Omicron, #OmicronVariant is apparently causing more admissions in children?we need to take precautions & vaccinate kids @PMOIndia ,@MoHFW_INDIA , @OfficeOf_MM ,@PrinSciAdvGoI , @shekhar_mande,@NITIAayog,@nvcmenon Image
@PMOIndia @MoHFW_INDIA @OfficeOf_MM @PrinSciAdvGoI @shekhar_mande @NITIAayog @nvcmenon Ctd2) vaccines seem to be working to some degree against the #Omicron in preventing deaths and hospitalizations at least to the information that we know now .#GetVaccinated, #OmicronIsAirborne, #Vaccinessavelives,@rubyslippahs Image
Read 14 tweets
28 Nov
I did a video consult with a family over a child with special needs , we end up discussing the #Omicron and then they say yeah.... we heard it is bad , a few sentences later - " Doctor we haven't been able to go out for our holidays, we are vaxxed can we go to xyz?" Ctd)
Ctd2) I am like " No , the kid is unvaxxed " They - " But we heard on Telly that the kids dont die " . That is how disinformation kills - We know since 1 year that kids with special needs have 6times more incidence of side effects of a Covid infection that a normal kid ctd)
Ctd3) that we need to understand this disinformation system doesnt discuss Long Covid in kids and that is for a purpose, it doesnt suit those running the factories if people dont turn up over fear of infection to their kids , that is why #COVIDisAirborne is not in discussion ctd)
Read 4 tweets
28 Nov
Nov 28 posts will be in the thread below , in this post I am posting the information as we came to know on Nov 26 and 27th and then the thread will continue.
Ctd1) while the UK asks for masking in public transport and shops it leaves schools and also leaves Pubs .Meanwhile Isreal which blocks entry of all foreigners makes an exception
Ctd2) Netherlands finds 13 cases of Omicron variant among passengers from South Africa.It is getting bigger - Israel, Denmark, UK, Australia, Hongkong , the question I am asked is why make these futile efforts- My answer is let's keep trying to stop the deluge ctd)
Read 17 tweets
27 Nov
Will try and keep everyone posted on the new developments on Omicron , the last thread became too lengthy in a day .But this is the information we had on 25/ 26 Nov. Ctd
Ctd2) I believe that it has become imperative that we immediately start finding whether the combination of Merck's Molnupiravir &Pfizers Antiviral is effective against Omicron?? we have had reports of Molnupiravir dropping efficacy yesterday in full trial.@hjelle_brian ctd)
@hjelle_brian Ctd3) virologists consider that the virus is " stealing " parts of our RNA as @hjelle_brian, to me it seems that these are efforts of virus to get past Interferons which are our defence mechanism .We know that those with Anti Interferon antibodies have bad course #Omicron ctd)
Read 25 tweets
26 Nov
Long thread 1) There is this fear about the new Botswana/ Nu/ B1.1.159 variant but let's delve into why is this fear?? The 4 cases they found in Botswana were all vaccinated.So what??Breakthrough happens all the time,we underestimate incidence @hjelle_brian ctd)
Ctd2) This variant marked in blue is coming up , so what?? These variants will come and go. Ist it was the Wuhan strain in Grey , then the Beta ( SA strain in Green , then the Delta in Red and now may be the Botswana variant in Blue ( B1.1.529) @MoHFW_INDIA, @mansukhmandviya ctd)
Ctd3) For the virus and also the vaccines ( Pfizer/ Moderna/ AZ) the spike protein is the most important and that is where the maximum risk is . The Delta had 2 changes in spike proteins Receptor Binding Domain, the Beta had 3 while the Nu has 10 , so there is a real risk ctd)
Read 35 tweets
25 Nov
Long Thread - With the new variants one from Botswana and the Second #C13 from South Africa , I am reminded of an old post @hjelle_brian ,@DrEricDing
For a variant to win against the Delta means a new Sumo wrestler is in town and that it has the potential ability to wipe out some of the herd immunity that we have achieved from the Delta .@PrinSciAdvGoI ,@narendramodi,@shekhar_mande ,@OfficeOf_MM

Ctd 3) Also the second variant of interest from Botswana is another one growing ,that means India should immediately stop flights from Africa and also again look at the travel hubs that have flights coming from Africa eg Dubai@HardeepSPuri,@JM_Scindia
Read 4 tweets

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