Long thread - The Nov 29th post & the information is all here below in the link posted and after that will be the updates for today ie 30th November@emilygraymd_mph ,@rubyslippahs,@GANyborg ,please add information that may have been missed @itosettiMD_MBA
Ctd1) A summary of what we know new about the current #Omicron, #OmicronVariant is apparently causing more admissions in children?we need to take precautions & vaccinate kids @PMOIndia ,@MoHFW_INDIA , @OfficeOf_MM ,@PrinSciAdvGoI , @shekhar_mande,@NITIAayog,@nvcmenon
@PMOIndia @MoHFW_INDIA @OfficeOf_MM @PrinSciAdvGoI @shekhar_mande @NITIAayog @nvcmenon Ctd2) vaccines seem to be working to some degree against the #Omicron in preventing deaths and hospitalizations at least to the information that we know now .#GetVaccinated, #OmicronIsAirborne, #Vaccinessavelives,@rubyslippahs
Ctd3) The number of cases which are severe is rising ( see orange Curve on Rt) and the proportion is at 30% , expected to rise further as time passes, so the discussion that#Omicron is milder is not true as per updated information
Ctd4) If you look at % of admissions who turn into severe disease there is not much difference (between 30% -45% ) across age groups, at the end of it the gross numbers will be important & as the elderly are vaxxed kids will dominate the total @emilygraymd_mph,@itosettiMD_MBA
Ctd5)Another of the mistakes many make is that only kids with comorbidities will need to go to hospitals , looking at ctd4 and here it is easy to understand that healthy kids will be needing hospitalizations much more that comorbid ones.@TigressEllie
Ctd6) From the graphs below it is absolutely clear that it is kids who are needing hospitalizations more than adults and elderly and from ctd 5 it is clear that these kids are absolutely healthy kids otherwise @MoHFW_INDIA , @PMOIndia , @narendramodi ,@PrinSciAdvGoI ,@iapindia
Ctd7) For those who say that #Omicron is less dangerous look at what it can cause the 133% increase in deaths has to be read with the negative ie -50% to -75% in other areas essentially a 200% increase in deaths& that is only 2 weeks,going to increase further @emilygraymd_mph
Ctd8)The hiatus between the sudden jump in cases and the last wave is at the max 12 weeks ie 3 months and this short duration confirms the fear about ability to evade #NaturalImmunity by #OmicronVariant #RPSMTrust
Ctd8) That is a huge acceptance of the problem that the #Omicron as we all have been saying repeatedly, there are too many spike protein changes , seemingly it will NOT protect against clinical disease BUT will prevent deaths and hospitalizations, though that may take a hit .
Ctd10) Countries need time to stockpile Molnupiravir, that can happen if we slow down spread
Ctd10) the time between 2 doses of AZ should be reduced from 16 weeks to 8-12 weeks duration.
Ctd11) The Netherlands confirm that they had the #Omicron in samples from 19th .The official SA reports came on 24th .rivm.nl/en/news/omicro…

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More from @Rpshahmemorial1

29 Nov
The posts from what we know in the last 3 days across the globe on #Omicron are all at one place here. Feel free to read along . The information from 29th November will follow in the thread below .Currently this is the known Geographic spread #RPSMTrust
Image
Ctd1) So there is a concern that the #Omicron is diversifying pretty fast, that concern in a population where 20% has HIV is a legitimate issue
Ctd2) All Variants of Concern have such clusters of sudden increase of mutations,the issue is they are coming up in an area where only 70% get access to Antiretroviral (HIV Tt) therapy,help needs to go a further step ahead - covid vaccines, antiretrovirals,logistics& Monoclonals
Read 21 tweets
28 Nov
I did a video consult with a family over a child with special needs , we end up discussing the #Omicron and then they say yeah.... we heard it is bad , a few sentences later - " Doctor we haven't been able to go out for our holidays, we are vaxxed can we go to xyz?" Ctd)
Ctd2) I am like " No , the kid is unvaxxed " They - " But we heard on Telly that the kids dont die " . That is how disinformation kills - We know since 1 year that kids with special needs have 6times more incidence of side effects of a Covid infection that a normal kid ctd)
Ctd3) that we need to understand this disinformation system doesnt discuss Long Covid in kids and that is for a purpose, it doesnt suit those running the factories if people dont turn up over fear of infection to their kids , that is why #COVIDisAirborne is not in discussion ctd)
Read 4 tweets
28 Nov
Nov 28 posts will be in the thread below , in this post I am posting the information as we came to know on Nov 26 and 27th and then the thread will continue.
Ctd1) while the UK asks for masking in public transport and shops it leaves schools and also leaves Pubs .Meanwhile Isreal which blocks entry of all foreigners makes an exception
Ctd2) Netherlands finds 13 cases of Omicron variant among passengers from South Africa.It is getting bigger - Israel, Denmark, UK, Australia, Hongkong , the question I am asked is why make these futile efforts- My answer is let's keep trying to stop the deluge ctd)
Read 17 tweets
27 Nov
Will try and keep everyone posted on the new developments on Omicron , the last thread became too lengthy in a day .But this is the information we had on 25/ 26 Nov. Ctd
Ctd2) I believe that it has become imperative that we immediately start finding whether the combination of Merck's Molnupiravir &Pfizers Antiviral is effective against Omicron?? we have had reports of Molnupiravir dropping efficacy yesterday in full trial.@hjelle_brian ctd)
@hjelle_brian Ctd3) virologists consider that the virus is " stealing " parts of our RNA as @hjelle_brian, to me it seems that these are efforts of virus to get past Interferons which are our defence mechanism .We know that those with Anti Interferon antibodies have bad course #Omicron ctd)
Read 25 tweets
26 Nov
Long thread 1) There is this fear about the new Botswana/ Nu/ B1.1.159 variant but let's delve into why is this fear?? The 4 cases they found in Botswana were all vaccinated.So what??Breakthrough happens all the time,we underestimate incidence @hjelle_brian ctd)
Ctd2) This variant marked in blue is coming up , so what?? These variants will come and go. Ist it was the Wuhan strain in Grey , then the Beta ( SA strain in Green , then the Delta in Red and now may be the Botswana variant in Blue ( B1.1.529) @MoHFW_INDIA, @mansukhmandviya ctd)
Ctd3) For the virus and also the vaccines ( Pfizer/ Moderna/ AZ) the spike protein is the most important and that is where the maximum risk is . The Delta had 2 changes in spike proteins Receptor Binding Domain, the Beta had 3 while the Nu has 10 , so there is a real risk ctd)
Read 35 tweets
25 Nov
Long Thread - With the new variants one from Botswana and the Second #C13 from South Africa , I am reminded of an old post @hjelle_brian ,@DrEricDing
For a variant to win against the Delta means a new Sumo wrestler is in town and that it has the potential ability to wipe out some of the herd immunity that we have achieved from the Delta .@PrinSciAdvGoI ,@narendramodi,@shekhar_mande ,@OfficeOf_MM

Ctd 3) Also the second variant of interest from Botswana is another one growing ,that means India should immediately stop flights from Africa and also again look at the travel hubs that have flights coming from Africa eg Dubai@HardeepSPuri,@JM_Scindia
Read 4 tweets

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