Pfizer updated #Covid19 #boosters re BA.1 buff.ly/3QQKV2z "Preliminary results suggest #vaccines could neutralize Omicron BA.4 & BA.5" If not, BA.4/5 and other emerging #variants may again have an INFECTION ADVANTAGE in VACCINATED amid still non-sterilizing #vaccines?! 
It happend before: "Rapid emergence of SARS-CoV-2 Omicron variant is associated with an infection advantage over Delta in vaccinated persons" cell.com/med/fulltext/S… #omicron #vaccination #covid19
"Early introduction and rise of the Omicron SARS-CoV-2 variant in highly vaccinated university populations" academic.oup.com/cid/advance-ar…
Where are the current hotspots; compare vaccination rates @nytimes nytimes.com/interactive/20…
Basics in Virology: "RNA viruses are unique in their evolutionary capacity, exhibiting high mutation rates and frequent recombination. They rapidly adapt to environmental changes, such as shifts in immune pressure or pharmacological challenge" annualreviews.org/doi/10.1146/an…
"Targeted vaccination and the speed of SARS-CoV-2 adaptation" pnas.org/doi/10.1073/pn…
It happened as predicted: "Of variants and vaccines" sciencedirect.com/science/articl…
"Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens" journals.plos.org/plosbiology/ar…
On the origin of #Omicron: Mechanisms of #coronavirus Evolution Revealing #Vaccine-Resistant #Mutations in Europe & America buff.ly/33aexne "...we reveal that the occurrence & frequency of vaccine-resistant mutations correlate strongly w/t #vaccination rates..." #covid19
SARS-CoV-2 #Omicron BA.2.12.1, BA.4, and BA.5 subvariants evolved to extend antibody evasion buff.ly/38Mir92 Is this evolution due to increased evolutionary pressure by non-sterilizing #vaccines?
When the models actually seem to work: "Vaccine escape in a heterogeneous population: insights for SARS-CoV-2 from a simple model" royalsocietypublishing.org/doi/full/10.10…
What impact can BA.1/2 targetting #vaccines have on BA.4/5 "robust neutralisation evasion by BA.4 & BA.5 ... are immune-evasion variants, which are more adept than BA.1/2 to spread in populations that are vaccinated or recovering from #omicron, or both buff.ly/3NvrgC4
@threadreaderapp
unroll
unroll
• • •
Missing some Tweet in this thread? You can try to
force a refresh
