Robert Bransfield, MD: Thousands of peer-reviewed journal articles demonstrate the causal association between infections and #mentalillness 400+ peer reviewed scientific articles demonstrate the causal association between tick-borne disease and mental illness. #ILADS2022#Lyme
3/Bransfield: Lyme is over represented in psychiatric patients. #ILADS2022
4/Bransfield: Consider #Lyme if:
● Acquired ADHD
● Regressive autism w/ childhood bipolar
● Panic attacks > 1⁄2 hour
● Childhood bipolar Sx
● Progressive white matter cognitive impairments with anxiety and depression
● Progressively declining mental state #ILADS2022
5/Bransfield: "Is there a point at which your health declined, followed by a fluctuating progression and development of multi-systemic symptoms, including cognitive, psychiatric, neurological, and somatic symptoms adversely impacting school, social life, family life?" #ILADS2022
7/Bransfield: Negative attitudes about #Lyme associated diseases from family, friends, doctors, & the health care system may also contribute to #suicide risk. By indirect calculations, it is
estimated there are possibly over 1,200 LAD suicides in the US per year #ILADS2022
8/Bransfield: Chronic #sleep disturbances occur in 100% of Lyme disease patients. Impaired Sleep Correlates with Impaired Immune Functioning.
Growth hormone is dependent upon delta sleep & modulates immune response. #ILADS2022#insomnia
9/Bransfield: Children are at the greatest risk. Children younger than 10 years old are bitten more frequently on the head and neck (49-80%) and bites on the head and neck correlate with neurological manifestations. #ILADS2022
10/Bransfield: Children Referred to Child Psychiatrist
● 80% (55 of 69) of children with ##psychiatric illness tested positive for tick-borne disease.
● 74% (20 of 27) of childhood #bipolar patients tested positive for tick-borne disease. #ILADS2022
11/Bransfield: Unlike adults, children with #Lyme often do not have a memory of healthy functioning. #ILADS2022
12/Bransfield: Pediatric #Lyme symptoms by the numers:
13/Bransfield: If a pediatric patients experiences an abrupt, dramatic onset of obsessive-compulsive disorder, consider PANS (autoimmune condition caused by variety of infections including #Lyme#Bartonella) or PANDAS (caused by #strep).
Samuel Shor, MD - Treating Lyme & Chronic Lyme
ILADS defines #chronicLymedisease (CLD) as a multisystem illness with a wide range of symptoms and/or signs that are either continuously or intermittently present for a minimum of six months #ILADS2022
2/Shor:
Only 18% of 1770 children with #Lyme disease
remember being bitten
Nigrovic LE, et al A minority of children diagnosed with Lyme disease recall a preceding tick bite 2019, Vol.10(3), p.694 #ILADS2022
3/Shor: The CDC acknowledges that its #Lyme case definition was developed for surveillance purposes. It is NOT to be used as an absolute criteria for clinical diagnosis. #ILADS2022
Joseph Burrascano, MD - Diagnostic Tools #Lyme Clinical Presentation: nonspecific, viral-like symptoms that persist, & new ones appear. Then symptoms more focused on musculoskeletal, peripheral and central nervous systems, heart and skin. Muti-systemic & migratory. #ILADS2022
2/Burrascano: B. microti and B. duncani (also known as WA-1) are the predominant cause of Babesiosis in the United States #Babesiosis has been detected in all 50 states #ILADS2022
3/Burrascano: #Babesia odocoilei has been found in ticks across N America, but not human samples, perhaps due to defective primers. Immunoblot data shows significant % of Babesia species in human patients are not microti or duncani. Could be divergens and/or odocoilei? #ILADS2022
2/Offutt Ticks are the primary vectors for spotted fevers; some species may be spread by fleas and mites #ILADS2022#RMSF#Richettsia
3/Offutt: #RMSF is the most severe rickettsial illness in the US with risk of death. Early treatment with #doxycycline is critical, regardless of age #ILADS2022