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Sep 25 • 7 tweets • 6 min read
Lineages to watch

1. BQ.1*
2. BQ1.1*
3. BA.2.75.2*
4. XBB - Recombinant of BJ.1 and BM.1.1.1
5. BA.2.3.20

All lineages have appreciable ACE2 affinity;
1-4 are highly immune evasive;
1 & 2 evade many therapeutics - #Evusheld and #Bebtelovimab

fortune.com/well/2022/09/2…
Credits to Lineage Spotters/Proposers

BA.2.3.20 - @LongDesertTrain
BQ.1*/BQ.1.1* - @siamosolocani
BA.2.75.2 - @agamedilab
XBB - @CorneliusRoemer

and the #LineageWatch team for 24/7 tracking & monitoring

cov-spectrum.org/collections/24…
BA.2.3.20 [ ⛳️to track Convergent Mutations]

@PangoNetwork Proposal/Background

H/T @LongDesertTrain

github.com/cov-lineages/p…
BQ.1/BQ.1.1 [ ⛳️to track Convergent Mutations]

@PangoNetwork Proposal/Background

H/T @siamosolocani

github.com/cov-lineages/p…
Recombinant XBB [ ⛳️to track Convergent Mutations]

@PangoNetwork Proposal/Background

H/T @CorneliusRoemer

github.com/cov-lineages/p…
BA.2.75.2 [ ⛳️to track Convergent Mutations]

@PangoNetwork Proposal/Background

H/T @agamedilab

github.com/cov-lineages/p…
#LineageWatch team has already spotted additional mutations on the BA.2.75.2 background

CA.1 (BA.2.75.2 + Spike L452R)

CA.1 is the next BA.2.75.2* lineage to watch closely!

H/T @JosetteSchoenma @CorneliusRoemer

github.com/cov-lineages/p… #CA1 #BA2752

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More from @RajlabN

Raj Rajnarayanan Profile picture
Sep 28
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

22.18% BA.5.2.1
12.64% BA.5.2
10.88% BA.4.6
10.02% BA.5.1
4.19% BA.5
3.63% BA.5.5
3.23% BA.5.6
3.04% BF.10
2.32% BA.5.2.9

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 09/27/22
1/n Image
Top circulating lineages:

82.4% BA.5*
10.9% BA.4.6*
2.7% BA.4*
1.4% BF.7*
0.8% BA.2.75*
0.7% BQ.1* 👀
0.2% BQ.1.1*👀
0.3% BA.2.75.2*
0.05% BA.2.3.20*
0.02% BJ.1*

2/n Image
.@CDCgov updated variant proportions estimates on 9/23/2022



3/n
Read 18 tweets
Raj Rajnarayanan Profile picture
Sep 27
Tracking BQ* lineages (BQ.1* & BQ.1.1*) over time

Emerging Hotspots:

BQ.1* (aka #Typhon) : #USA, #UnitedKingdom, #Denmark, #Canada, #Germany

BQ.1.1* (aka #Cerberus): #UnitedKingdom, #USA, #France, #Denmark, #Belgium

Tracker: public.tableau.com/app/profile/ra…

Updated 9/27/2022 12 pm
Tracking BQ.1* (aka #Typhon)/BQ.1.1* (aka #Cerberus) in the #UnitedKingdom over time

#England is a BQ.1/BQ.1.1 hotspot!

Please get #boosted and #MaskUp!

Note: Latest Epi Weeks are incomplete ImageImage
Tracking BQ.1* (aka #Typhon)/BQ.1.1* (aka #Cerberus) in #USA over time

#Texas, #NewYork, #NewJersey, #California, #Georgia #Maryland #Connecticut are emerging BQ.1/BQ.1.1 hotspots!

Please get #boosted and #MaskUp! ImageImage
Read 4 tweets
Raj Rajnarayanan Profile picture
Sep 27
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

22.33% BA.5.2.1
12.87% BA.5.2
10.53% BA.4.6
10.33% BA.5.1
3.71% BA.5
3.69% BA.5.5
3.43% BA.5.6
3.11% BF.10
2.67% BA.5.2.9
1.59% BF.5

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 09/26/22
1/n Image
Top circulating lineages:

82.62% BA.5*
10.53% BA.4.6*
2.68% BA.4*
1.45% BF.7*
0.94% BA.2.75*
0.62% BQ.1* 👀
0.20% BQ.1.1*👀
0.25% BA.2.75.2*
0.05% BA.2.3.20*
0.03% BJ.1*

2/n Image
.@CDCgov updated variant proportions estimates on 9/23/2022



3/n
Read 17 tweets
Raj Rajnarayanan Profile picture
Sep 26
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

21.86% BA.5.2.1
12.79% BA.5.2
11.39% BA.4.6⬆️
10.89% BA.5.1
3.83% BA.5
3.55% BA.5.5
3.13% BA.5.6
3.02% BF.10
2.55% BA.5.2.9
1.59% BF.5

Tracker: tinyurl.com/mryj4uu7

#OmicronUpdates 09/25/22
1/n Image
Top circulating lineages:

82.23% BA.5*
11.39% BA.4.6*
2.35% BA.4*
1.37% BF.7*
1.04% BA.2.75*
0.67% BQ.1* 👀
0.21% BQ.1.1*👀
0.18% BA.2.75.2*
0.05% BA.2.3.20*
0.05% BJ.1*

2/n Image
BA.5* group of lineages have outcompeted all other circulating lineages in the USA.

@CDCgov updated variant proportions estimates on 9/23/2022



3/n
Read 17 tweets
Raj Rajnarayanan Profile picture
Sep 14
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

31.05% BA.5.2.1
17.11% BA.5.2
12.23% BA.5.1
9.03% BA.4.6
5.08% BA.5.5
5.03% BA.5.6
4.01% BA.5
2.19% BA.4.1
2.01% BF.5
1.50% BE.1

Tracker: tinyurl.com/mryj4uu7

#OmicronUpdates 09/13/22
1/n
Top circulating lineages:

84.80% BA.5*
12.56% BA.4* [of which 9.03% BA.4.6]
0.94% BA.2.75* 👀
1.7% Others

2/n
Now the spotlight is on #Oregon, #NewHampshire, #Maine & #Maryland!

Week-over-week trend in new confirmed SARSCoV2 positive cases is >60%

Source: charts.medriva.com/us/

3/n
Read 15 tweets
Raj Rajnarayanan Profile picture
Sep 13
CDC #NOWCAST Variant Proportions Predictions
- #USA (updated on 09/13/22)

87.5% BA.5* (S:L452R/F486V; M:D3N) ↔️
9.2% BA.4.6 (S:R346T)
2.2% BA.4 (S:L452R/F486V; N:P151S)
1% BA.2*
0.1% BA.2.12.1* (S:L452Q)⬇️

Get #Boosted and #MaskUp

Source: covid.cdc.gov/covid-data-tra…

@CDCgov
Consistent with #15DayTrends
CDC nowcast predicts HHS Region 7 as a BA.4.6 lineage (dark blue color) hotspot
Read 4 tweets

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