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Oct 4 • 8 tweets • 7 min read
Tracking #SARSCoV2 Lineages with the "#Convergent #Quintet" mutations over time - Globally |

BQ.1 (#Typhon)/BQ.1.1(#Cerberus) is currently at the top!

Key #Spike amino acids tracked: 346, 356, 444-446, 450, 452, 460, 486, 490, 493-494

public.tableau.com/app/profile/ra…

10/4/2022 update
Note: Some of the tracked sub-lineages have not picked up all of the key convergent mutations but they eventually will (for example BA.2.3.20)

2/n
Granular details - "Convergent Quintet"

BQ.1/BQ.1.1 and BA.2.75.2 are heading the charts!

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Tracked lineages with the #Convergent #Quintet are predicted to be immune evasive and bind to host ACE2 receptor better than Omicron.BA2

Closely watched lineages - XBB, CA.1, BQ.1.1, BN.1, BR.3

4/n
Why are we watching these lineages?



5/n
Live tracking of convergent lineages with the @GenSpectrum #Collection54 by @CorneliusRoemer

cov-spectrum.org/collections/54
Track relative growth advantages of the top circulating lineages with @GenSpectrum #Collection24 maintained by @siamosolocani/ @Asinickle1

Collection24: cov-spectrum.org/collections/24

How to use it (H/T @siamosolocani):
6/n
Excellent way to visualize the #convergent #Quintet in action over time!

H/T @JPWeiland



7/n

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More from @RajlabN

Raj Rajnarayanan Profile picture
Oct 5
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

22.0% BA.5.2.1
13.6% BA.5.2
11.0% BA.4.6
9.9% BA.5.1
3.7% BF.10
3.5% BA.5.5
3.0% BA.5.6
2.4% BA.5.2.9
2.1% BF.7
2.0% BA.5

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 10/04/22
1/n
Top circulating lineages (#15DayTrends)

81.6% BA.5*
11% BA.4.6*
2.1% BF.7*
1.2% BA.2.75*
1.5% BA.4*
1.2% BQ.1*
0.5% BQ.1.1*
0.3% BA.2.3.30*
0.04% XBB*

2/n Image
.@CDCgov updated variant proportions estimates on 9/30/2022



3/n
Read 14 tweets
Raj Rajnarayanan Profile picture
Oct 4
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

21.4% BA.5.2.1
13.6% BA.5.2
10.9% BA.4.6
9.9% BA.5.1
3.9% BF.10
3.5% BA.5.5
3.0% BA.5.6
2.2% BF.7
2.2% BA.5.2.9
1.8% BA.5

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 10/03/22
1/n
Top circulating lineages (#15DayTrends)

81.7% BA.5*
10.9% BA.4.6*
2.2% BF.7*
1.5% BA.2.75*
1.4% BA.4*
1.4% BQ.1*
0.5% BQ.1.1*
0.2% BA.2.3.30*
0.02% XBB*

2/n
.@CDCgov updated variant proportions estimates on 9/30/2022



3/n
Read 15 tweets
Raj Rajnarayanan Profile picture
Oct 3
Circulating BA.2.75* & XBB* lineages in the world

Top circulating BA.2.75* (#30DayTrends):

BA.2.75.2,
BA.2.75.5,
BM.1.1,
BA.2.75.1,
BL.1,
BN.1,
XBB, 👀⬆️
BY.1,
BL.2,
BA.2.75 &
BM.4.1.1

public.tableau.com/app/profile/ra…

Updated 10/03/2022
Tracking BA.2.75* and XBB lineages in the #Singapore #30DayTrends

Top circulating lineages: XBB, BA.2.75.2, BA.2.75.5, BM.1.1, BL.2 and BL.1 ImageImageImage
Tracking BA.2.75* and XBB lineages in the #India #30DayTrends

Top circulating BA.2.75*: BA.2.75.2, BA.2.75.5, BM.1.1, BL.1, BA.2.75.1, BM.4.1.1, BY.1 and BL.2

Hotspots: #TamilNadu, #Gujarat, #Odisha & #Maharashtra ImageImage
Read 5 tweets
Raj Rajnarayanan Profile picture
Oct 3
Status of the latest #COVID19 Wave in #NewYork #BellwetherState

NY just uploaded 425 sequences - had to update charts!

Top circulating variants - BA.5.2.1 (20%), BA.4.6 (15%)

Proportion of BQ* lineages are increasing
BQ.1* (2.84%) & BQ.1.1* (1.00%)👀 ImageImage
BQ.1.1 (aka #Cerberus) is able to evade all available mAb therapeutics including #Evusheld and #Bebtelovimab.

Bivalent boosters (OG/Omicron.BA.5) will potentially protect the boosted from getting severe disease.

Please get #boosted ASAP! Image
We may have to switch to #SequenceToTreat from #TestToTreat soon...

mAbs work well against BA.2.3.20

#Bebtelovimab works well against most BA.2.75* without spike K444 mutations

None of the mAb currently authorized by @US_FDA will work against BQ.1. lineage
Read 4 tweets
Raj Rajnarayanan Profile picture
Oct 3
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

23.2% BA.5.2.1
13.5% BA.5.2
10.6% BA.5.1
10.0% BA.4.6
4.0% BF.10
3.3% BA.5.5
2.8% BA.5.6
2.4% BA.5.2.9
2.2% BF.7
2.0% BA.5

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 10/02/22
1/n
Top circulating lineages (#15DayTrends)

83.7%BA.5*
10% BA.4.6*
2.2%BF.7*
1.5%BA.4*
1.2%BA.2.75*
0.5%BQ.1*
0.3%BA.2.3.30*
0.4%BQ.1.1*

2/n Image
.@CDCgov updated variant proportions estimates on 9/30/2022



3/n
Read 15 tweets
Raj Rajnarayanan Profile picture
Sep 28
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

22.18% BA.5.2.1
12.64% BA.5.2
10.88% BA.4.6
10.02% BA.5.1
4.19% BA.5
3.63% BA.5.5
3.23% BA.5.6
3.04% BF.10
2.32% BA.5.2.9

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 09/27/22
1/n
Top circulating lineages:

82.4% BA.5*
10.9% BA.4.6*
2.7% BA.4*
1.4% BF.7*
0.8% BA.2.75*
0.7% BQ.1* 👀
0.2% BQ.1.1*👀
0.3% BA.2.75.2*
0.05% BA.2.3.20*
0.02% BJ.1*

2/n
.@CDCgov updated variant proportions estimates on 9/23/2022



3/n
Read 18 tweets

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