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Nat’s Pancreas 404 🐝 #DavosSafe Profile picture
@1derfultype
Oct 14, 2022 • 7 tweets • 15 min read • Read on X
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Potential role of antiviral treatment in #T1D:

Pathogenesis:
1⃣ Genetic susceptibility
2⃣ Something triggers autoimmunity in the 1st years of life or later
3⃣ #BetaCell destruction
4⃣ Diagnosis
-L. Krogvold

#ISPAD #ISPAD2022 #dedoc°voices #patientvoice @dedocORG @ispad_org 1/n
Potential role of antiviral treatment in #T1D:

'The time trend is the best proof that there are environmental factors triggering T1D.
Heredity as well.'
-L. Krogvold

#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #payitforward @dedocORG @ispad_org 2/n
Potential role of antiviral treatment in #T1D:

'From the 1920s we knew that T1D was of viral origin as deaths from #diabetes in Norway correlated with the mumps pandemic.'
-L. Krogvold

#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs @dedocORG @ispad_org 3/n
Potential role of antiviral treatment in #T1D:

'There is a clear association between #enterovirus infection and #BetaCells autoimmunity.'
-L. Krogvold

#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #payitforward @dedocORG @ispad_org 4/n
Potential role of antiviral treatment in #T1D:

DIVID study re the underlying causes of T1D:
▶️ Pancreatic biopsy
▶️ 6 newly diagnosed adults
▶️ 40 peer reviewed articles
▶️ Live #entovirus detected at onset
-L. Krogvold

#ISPAD #ISPAD2022 #dedoc° @dedocORG @ispad_org 5/n
Potential role of antiviral treatment in #T1D:

First lessons from #Covid:
⬆️ incidence of #T1D
❓ Has this ⬆️ incidence been triggered by Covid or is this an acceleration of already triggered autoimmunity?
-L. Krogvold

#ISPAD #ISPAD2022 #dedoc° @dedocORG @ispad_org
6/n
Potential role of antiviral treatment in #T1D:

Second lessons from #Covid:
⚠️ #SARSCoV2 enters the pancreatic #BetaCells
▶️ Beta cells intracellular signalling
▶️ Apoptosis, impaired #insulin secretion & transdifferentiation
-L. Krogvold

#ISPAD2022 #dedoc° @dedocORG 7/n

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More from @1derfultype

Nat’s Pancreas 404 🐝 #DavosSafe Profile picture
Oct 18
🧵 Adult care perspective on interventions for macrovascular complications in #T1D -D Mauricio

⬆️ CVD risk
⬆️ Large gap in CVD outcomes: morbidity + mortality
⬆️ Excess mortality ⬆️ when early onset
⬆️ Years lost consistently proven

#ISPAD2024 #dedoc° @ispad_org @dedocORG #PwD Adult care perspective on interventions for macrovascular complications (how early to intervene) -D Mauricio
Image
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🧵 Adult care perspective on interventions for macrovascular complications in #T1D -D Mauricio

🫀 Excess CVD risk (average in T1D):
⬆️ Morbidity: 🚹x2.4-3.6 & 🚺 x3.0-7.7
⬆️ Mortality: 🚹x2.6-8.8 & 🚺 x2.7-24.7 😨

Early T1D onset next ⤵️

#ISPAD2024 #dedoc @ispad_org @dedocORG Adult care perspective on interventions for macrovascular complications in #T1D -D Mauricio: Excess CVD risk
@ispad_org @dedocORG 🧵 Adult care perspective on interventions for macrovascular complications in #T1D -D Mauricio

🫀 Excess+ #CVD risk in early T1D onset:
⬆️ Morbidity: x11.4 if <10yo & x3.8 if >26yo
⬆️ Mortality: x7.4 if <10yo & x3.6 if >26yo

⬆️⬆️⬆️ for 🚺

#ISPAD2024 #dedoc° @ispad_org Adult care perspective on interventions for macrovascular complications in #T1D -D Mauricio: Excess+ CVD risk in early T1D onset
Read 18 tweets
Nat’s Pancreas 404 🐝 #DavosSafe Profile picture
Oct 16, 2022
🧵How can #HCP assist people who chose to use #DYIAID?

The @OPENDiabetesEU ⤵️
▶️ Katarina Braune is a co-founder
▶️ Patient-led
▶️ 2/3 of the international team live w/#T1D
▶️ #OpenSource #AID data

#ISPAD2022 #dedoc°voices #wearenotwaiting @dedocORG @ispad_org 1/n
How can #HCP assist people who chose to use #DYIAID?

#wearenotwaiting movement ⤵️
Because DIY #ClosedLoop systems have been so life-changing for them and their kids, they decided to make it available for all.

#ISPAD2022 #dedoc°voices #payitforward @dedocORG @ispad_org 2/n
How can #HCP assist people who chose to use #DYIAID?

International consensus statement on #OpenSource automated insulin delivery ⤵️
✅ Published in @TheLancetEndo on Nov 13 2021
▶️ thelancet.com/journals/landi…

#ISPAD2022 #dedoc°voices #payitforward @dedocORG @ispad_org 3/n
Read 22 tweets
Nat’s Pancreas 404 🐝 #DavosSafe Profile picture
Oct 16, 2022
🧵#AI based decision support systems:

✅ Improves clinical outcomes
✅ Higher access to care
✅ Provides precision medicine
-Revital Nimri

#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #diabetesadvocacy #patientvoice #payitforward @dedocORG @ispad_org 1/n
#AI based decision support systems:

'Is the quality of care improving?
No, it isn't.
We must do better.'
-Revital Nimri

#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #diabetesadvocacy #patientvoice #payitforward @dedocORG @ispad_org 2/n
#AI based decision support systems:

✅ Self-management tools
✅ Diagnosis, screening, prevention of #diabetes
✅ Prediction tools
✅ Clinical management
-Revital Nimri

#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #payitforward @dedocORG @ispad_org 3/n
Read 6 tweets
Nat’s Pancreas 404 🐝 #DavosSafe Profile picture
Oct 16, 2022
@lifeforachild /@ispad_org survey - shifting responsibility:
'I am an advocate because I believe that evidence should be made accessible to every stakeholder.'
-Emma Klatman ❤️

#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #payitforward @dedocORG 1/n
@lifeforachild /@ispad_org survey - shifting responsibility:
'Task-shifting & task-sharing: moving a task on from one #HCP to another & where staff from different discipline split the tasks. We are very interested in task-shifting in #T1D'
-Emma Klatman ❤️

ISPAD2022 #dedoc° 2/n
@lifeforachild /@ispad_org survey - shifting responsibility:
'We want to document the level of task-shifting and understand who from the clinical team is doing what. We established en survey in 2021 in many languages.'
-Emma Klatman ❤️

#ISPAD #ISPAD2022 #dedoc° @dedocORG 3/n
Read 8 tweets
Nat’s Pancreas 404 🐝 #DavosSafe Profile picture
Oct 15, 2022
The tragedy of non-diagnosis of #T1D, results from the #T1Dindex -G. Ogle:

Missed T1D diagnoses are legion 💔

1⃣9⃣8⃣7⃣ Sydney: a 15yo boy passed away because of misdiagnosis as he'd just had chicken pox

#ISPAD #ISPAD2022 #dedoc°voices @lifeforachild @ispad_org 1/n Image
The tragedy of non-diagnosis of #T1D, results from the #T1Dindex -G. Ogle:

1⃣9⃣9⃣6⃣ Phnom Penh: no child alive with T1D in Cambodia then.
A boy had a late diagnosis, had had a dose on #insulin, but no fluid yet. He passed away 💔

#BG: 105mmol/1890mg

#ISPAD2022 #dedoc° 2/n Image
The tragedy of non-diagnosis of #T1D, results from the #T1Dindex -G. Ogle:

2⃣0⃣1⃣5⃣ Ghana: an 18yo girl was misdiagnosed with ectopic pregnancy because of acute abdomen, died during theatre where T1D diagnosis was made 💔

#ISPAD2022 #dedoc°voices @lifeforachild @ispad_org 3/n Image
Read 13 tweets
Nat’s Pancreas 404 🐝 #DavosSafe Profile picture
Oct 15, 2022
🧵Digital health for improving self-care and mental health in youth with T1D:

Benefits of tech:
▶️ scalable particularly in mental health interventions
▶️ reduce stigma
▶️ accessible 24/7
▶️ taylored tools
-Anna Serlachius

#ISPAD #ISPAD2022 #dedoc°@dedocORG @ispad_org 1/n
Digital health for improving self-care and mental health in youth with #T1D:

Challenges of tech:
▶️ access
▶️ literacy
▶️ security
▶️ clinicians awareness
-Anna Serlachius

#ISPAD #ISPAD2022 #dedoc°voices
#diabetesadvocacy #patientvoice #payitforward @dedocORG @ispad_org 2/n Image
Digital health for improving self-care and mental health in youth with #T1D:

Challenges of tech:
▶️ engagement matters
▶️ make sure to include users during development
-Anna Serlachius

#ISPAD #ISPAD2022 #dedoc°voices
#diabetesadvocacy #payitforward @dedocORG @ispad_org 3/n Image
Read 8 tweets

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