At which age do we start to lose muscle mass?

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#ageing #muscle #sarcopenia
Aging is associated with the loss of muscle mass. This phenomenon is also known as sarcopenia. Around what age does this start to occur?

2/
This study investigated the influence of age on muscle mass in a large sample of adults. Skeletal muscle mass was measured with a whole-body MRI for 468 adults of 18-88 years old. People that were bedridden, had physical disabilities, or had chronic illnesses were excluded.

3/
Skeletal muscle mass is stable until the mid-40s, after which a negative correlation between muscle mass and age was observed. In addition, muscle loss appeared to accelerate with increasing age.

4/
Muscle mass loss was greater in the lower body when compared to the upper body. This may be explained by a reduction in physical activity of primarily the lower body.

5/
A limitation of the study is that it’s cross-sectional. However, cohort or intervention research is not really feasible for this research question.

6/
In conclusion, the age-related loss of muscle mass appears to begin around the age of 45 years.

Study:
ncbi.nlm.nih.gov/pubmed/10904038

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