1. 32-year old Tina was happy & cheerful for 27-28 days every month, however, she feared facing the remaining 3-4 days. She hopelessly wished that those days never ever came, but that was not possible. #medTwitter#neurotwitter
2. Tina used to get severe headaches that occurred only on 3-4 days every month. These days were 1-2 days prior to her menses or during the first two days of menses. She never experienced headache on other days of the month. She had regular periods and had a 2-year old child too.
3. Headaches were severe with a score of 7-8 on visual analog scale (where 10 is the most severe pain, and 0 is absence of pain). Tina had nausea, vomiting and dizziness associated with headache.
Headaches lasted 24-36 hours and they left her completely incapacitated.
4. Headaches took a heavy toll on Tina's personal and professional lives. She was unable to give quality time to child and husband on those 3-4 days.
She was also not in a position to go to office. She was a software professional and had to routinely take leave on 2-3 days/month.
5. Tina consulted gynecologist and physician, but the treatment did not help much. Gynecologist told her that everything is normal. Physician tried pain-killers, which didn't help Tina much. She also tried meditation and yoga, which helped a bit but not significantly.
6. Frequent sick leaves created a negative impact about her in office. Colleagues had to work extra, doing Tina's share of job too.
Tina looked for support from her boss (a woman), but was dismissed saying "every woman has menses, are you someone special, who needs leave?"
7. Tina had resigned to her fate, and felt there is no hope left. She felt sad, anxious and had lack of sleep too. She was depressed. These resulted in her getting more severe headaches. When she reviewed with her physician, she was asked to consult a neurologist.
8. I reviewed Tina's history.
Headaches started 2 yrs back (post-delivery). She had no prior headaches. They occurred on two days before menses or on first two days of menses. There was no aura prior to headache. There were no other precipitating factors.
Diagnosis was clear now
9. The diagnosis was catamenial migraine, also called pure menstrual migraine (PMM).
Headaches in PMM can occur 2 days prior to menses or during first 3 days of menses (-2 to +3).
Migraine during this period may be triggered by oestrogen withdrawal.
10. No tests were needed to confirm the diagnosis, as the diagnosis of PMM is based on history. I explained the diagnosis to Tina and discussed the treatment options.
She opted to take medical treatment on those 5 days every month. Daily medicines are not needed.
11. At 1-month review, she reported headache on only 1 day. During the next 3 months, she had 0-1 day headache per month. Moreover, the duration of headache was only 12 hours, and severity too had reduced.
Tina's quality of life improved, and she didn't require leave from work.
12. Take home message
*Headaches occurring on 2 days prior to menses or during first 3 days of menses during 2 out of 3 previous months is suggestive of pure menstrual migraine.
*Medical treatment on those 5 days results in excellent relief from headache & better quality of life.
Drinking hot tea could increase the risk of esophageal cancer
1. Drinking tea is known to lower the risk of cancers, however, if tea is consumed hot, the risk of esophagus (food pipe) cancer can increase. #MedTwitter#Cancer#tea doi.org/10.3389%2Ffnut…
2. The overall results of the meta-analysis showed that people who drank hot tea had 77% higher risk of esophageal cancer than those who do not drink hot tea.
3. Green tea is rich in polyphenols, which have been extensively studied as a cancer chemo-preventive agent.
Epigallocatechin gallate (EGCG), the most abundant and active compound in tea, was reported to block cancer progression.
Non-nutritive sweetened beverages (NNSB) could be a viable alternative for sugar-sweetened beverages (SSB) in people trying to cut calories
1. Harmful effects of SSB such as soft drinks & packaged juices on diabetes and weight are well known. Are NNSBs an alternative in them?
2. A recent systematic review compared the acute (short-duration) impacts of NNSBs and SSBs on metabolic and endocrine parameters. Thirty-six trials involving 472 predominantly healthy participants were included. doi.org/10.3390/nu1504…
3. NNS beverages had no effect on postprandial glucose, insulin, GLP-1, GIP, PYY, ghrelin, and glucagon responses (similar to water controls), whereas SSBs sweetened with caloric sugars (glucose and sucrose) increased postprandial glucose, insulin, GLP-1, and GIP responses.
A teenager referred with "difficult to control" fits needed non-drug approach for controlling fits
1. 15-year old Rishi had been having fits for the past three months. He used to have jerky movements of hands and legs that lasted several hours and occurred 15-20 times per day.
1a. He was seen by local doctors. MRI brain & EEG were normal.
He was started on anti-epileptic drug (AED). As seizures did not get controlled with single AED, two more drugs were sequentially added. As seizures continued despite giving maximum doses of 3 AEDs, he was referred.
2. Rishi had no past history of fits or febrile seizures in early childhood. There was no family history of epilepsy. He was a bright kid, doing well in studies.
While in OPD, I witnessed one of the episodes of fits, which made me suspect the root cause of fits in Rishi.
Lifelong endurance sport participation on top of a healthy lifestyle is not associated with a more favorable coronary plaque composition.
1. The dose response between long-term endurance exercises such as running or cycling & coronary artery disease (CAD) is a subject of debate
1a. A recent study looked at the association between long-term endurance exercises and prevalence of coronary artery plaques.
2. Three groups of people were selected:
Group 1 had started exercising below age 30,
group 2 started after age 30, and
3rd group maintained healthy lifestyle with minimal exercises. #running#cycling#endurance#HeartAttack
Lack of sleep (<5 h) and excessive sleep (>9 h), both increase the risk of heart attack 1. Insomnia (lack of sleep) is not considered a traditional risk factor for heart attack.
A recent study examined the association between sleep duration and risk of heart attacks. #MedTwitter
2. People with insomnia had 69% higher risk of myocardial infarction (MI, heart attack).
The risk of MI was higher among those who slept <5 hours or <6 hours as compared to those who slept 7-8 hours/night. doi.org/10.1002/clc.23…
3. Excessive #sleep also increased the risk of #heartattack.
People who slept 9 hours or more had a higher risk of heart attack as compared to those who slept 6-8 hours per night.
Sleeping >9 hours and sleeping <5 hours , both increased the risk of heart attack. #CardioTwitter
The prevalence of diabetes and obesity has increased in young adults over the past decade
1. We are witnessing higher numbers of heart attack and stroke in young adults (aged 50 & below). We need to identify the risk factors so that heart attack & stroke can be prevented in them
2. In a recent study, the prevalence of #diabetes increased from 3.0% to 4.1% and #obesity from 32.7% to 40.9% during 2017-20, as compared to 2009-10, among young adults aged 20-44.
3. Other issue of concern is that most of these young individuals are not aware of their cardiovascular risk factors, with 40-50% of them not on any treatment.
Additionally, among those who receive treatment, 30-40% have poor BP or sugar control.