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Raj Rajnarayanan Profile picture
@RajlabN
Apr 30, 2023 • 8 tweets • 10 min read • Read on X
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Tracking #SARSCoV2 #Lineages - Globally

Top lineages -#20DayTrends (#G20):

XBB.1.5 (36.6%)⬇️
XBB.1.9.1 (11.5%)⬆️
EG.1 (4.7%)⬆️
XBB.1.16 (4.4%)⬆️
XBB.1.9.2 (3.1%)
XBB.2.3 (1.8%)
XBB.1.5.13 (1.6%)
XBB.1.16.1 (1.5%)

public.tableau.com/app/profile/ra…

Updated 04/29/23 Image
Granular details #Global #20DayTrends

This analysis includes all designated #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 04/09/2023 (14,137 sequences) Image
#USA, #Austria, #France & #Canada have submitted a lion's share of sequences with sample collection dates on or after 04/09/2023 ...followed by #UnitedKingdom, #Australia, #Germany, #Sweden, #SouthKorea, #Singapore, #China, #Spain Image
In Silico Immune escape and ACE2 receptor binding scores (relative to BA.2)*

Data is intended to prioritize select lineages to generate rapid laboratory experiments to gauge immune escape and ACE2 binding affinity.

[Credits in the legend] * Only Spike RBD mutations considered Image
#SARSCoV2 lineages in the zone of concern (red box) - Predicted to have high immune escape and tight ACE2 binding activity - A Closer look

XBB.1.16* family (XBB.1.16.1, FU.1, FU.2, XBB.1.16.2, XBB.1.16.3) cluster together

Chart: public.tableau.com/app/profile/ra… Image
What to expect in the next few weeks?

github.com/neherlab/SARS-…

Excellent SARSCoV2 Variant report
by @richardneher @CorneliusRoemer
“Currently, XBB.1.16 is the big dog” ... “It’s picking up mutations that are common in other variants that will increase its advantage further.”

H/T @ErinMPrater @WellatFortune
@FortuneMagazine
fortune.com/well/2023/03/3…
A closer look at #Arctrus (XBB.1.16*), #Hyperion (XBB.1.9*) and #Acrux (XBB.2.3*) constellations

more on common names from @TRyanGregory
Image

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More from @RajlabN

Raj Rajnarayanan Profile picture
Sep 27
#SARSCoV2 #VariantProportions - #USA |09/27/24

@CDCgov #Nowcast 2-Week estimates

KP.3.1.1 (JN.1.11.1.3.1.1) is still the top circulating lineage in the USA

🚨XEC makes an entry @ 5.7%



1/n covid.cdc.gov/covid-data-tra…
Image
Reliable nowcast estimates are available only for HHS regions 2, 3, 4, 5, 7 and 9

Other regions did not sequence enough

2/n Image
KP.3.1.1* group of lineages

In the @CDCgov nowcast chart....
KP.3.1.1* is not further separated in to MC.1-MC.16 sub-lineages

3/n Image
Read 6 tweets
Raj Rajnarayanan Profile picture
Sep 8
Tracking #SARSCoV2 #Lineages - Globally |09/07/24

Top lineages -#30DayTrends

KP.3.1.1 (37.1%)
KP.2.3 (9%)
KP.3.3 (5.7%)
KP.3.1 (2.9%)
XDV.1 (2.9%)
KP.1.1.3 (2.7%)
LB.1 (2.3%)
LB.1.3 (2.1%)
KP.2.2 (2%)
---
XEC (1.4%)👀

Track #G30 :

1/n public.tableau.com/app/profile/ra…
Image
Granular details #Global #30DayTrends

KP.3.1.1* is still the top circulating group of lineages in the world.

This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 08/08/2024 (12,884 sequences)

2/n Image
@GISAID Thanks to all the countries that are supporting #SARSCoV2 testing and rapidly submitting sequences to @GISAID

Top submitters #USA #Canada #UK #Sweden #Japan
#China #Spain #Australia #Germany #Denmark #SouthKorea #France #Singapore #NewZealand #Ireland #Italy #Netherlands Image
Read 16 tweets
Raj Rajnarayanan Profile picture
Sep 1
What the XEC!

Recombinant #SARSCoV2 lineage #XEC (recombinant of KS.1.1/KP.3.3) has the potential to outcompete other circulating lineages in #USA (and other countries)

More data is needed to provide a reliable growth advantage estimates
Image
#VariantHunters are closely monitoring XEC.1 with signature mutations Spike K182R & ORF1a:L4182F
XEC.1 was proposed by #VariantHunter @siamosolocani

github.com/sars-cov-2-var…
Read 5 tweets
Raj Rajnarayanan Profile picture
Aug 25
Tracking #SARSCoV2 #Lineages - Globally |08/25/24

Top lineages -#30DayTrends

KP.3.1.1 (30.1%)👀
KP.2.3 (11%)
KP.3.3 (7.1%)
KP.3.1 (4.2%)
LB.1.7 (2.7%)
KP.2 (2.5%)
LB.1 (2.5%)
KP.1.1.3 (2.5%)
KP.2.2 (2.2%)
---
XEC (0.4%)

Track #G30 :

1/n public.tableau.com/app/profile/ra…
Image
Granular details #Global #30DayTrends

KP.3.1.1* is the top circulating group of lineages in the world. This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 07/25/2024 (14,688 sequences)

2/n Image
@GISAID Thanks to all the countries that are still supporting #SARSCoV2 testing and rapidly submitting sequences to @GISAID

Top submitters: #USA #Canada #UK #Japan #Spain
#Sweden #Netherlands #SouthKorea #Denmark #Israel #Ireland #Singapore #Australia #China #Germany #Italy #France Image
Read 17 tweets
Raj Rajnarayanan Profile picture
Aug 11
Tracking #SARSCoV2 #Lineages - Globally |08/10/24

Top lineages -#30DayTrends

KP.3.1.1 (24.2%)👀
KP.2.3 (9.5%)
KP.3.3 (8.4%)
KP.3.1 (5.9%)
LB.1 (2.5%)
KP.2.2 (2.4%)
KP.2 (2.4%)
KP.3 (2.3%)
LB.1.7 (2.3%)
KP.3.2.3 (2.2%)

Track #G30 :

1/n public.tableau.com/app/profile/ra…
Image
Granular details #Global #30DayTrends

KP.3.1.1 is the top circulating lineage in the world. This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 07/11/2024 (15,325 sequences)

2/n Image
@GISAID Thanks to all the countries that are still supporting #SARSCoV2 testing and rapidly submitting sequences to @GISAID

Top submitters: #USA #Canada #UK #Japan #Spain
#France #China #Netherlands #Israel #Ireland
#Australia #Singapore #Denmark #Italy #Sweden #Germany #Guatemala Image
Read 21 tweets
Raj Rajnarayanan Profile picture
Jul 28
Tracking #SARSCoV2 #Lineages - Globally |07/27/24

Top lineages -#30DayTrends

KP.3.1.1 (17.4%)👀
KP.2.3 (8.1%)
KP.3.3 (8%)
KP.3.1 (7.2%)
KP.3 (3.3%)
KP.2 (3.1%)
KP.3.1.4 (3.1%)
KP.3.2 (3%)
LB.1 (2.5%)
KP.3.2.3 (2.5%)

Track #G30 :

1/n public.tableau.com/app/profile/ra…
Image
Granular details #Global #30DayTrends KP.3* is the dominant group of lineages in the world.

This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 06/27/2024 (12,753 sequences)

2/n Image
Thanks to all the countries that are still supporting #SARSCoV2 testing and rapidly submitting sequences to @GISAID

Top submitters: #USA #UK #Canada #Spain #Japan #Israel #Australia #Ireland #France #Denmark #Singapore #NewZealand #Germany #Netherlands #Sweden #Taiwan

3/n Image
Read 15 tweets

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