Thread by @RajlabN

Tracking #SARSCoV2 #Lineages - Globally

Top lineages -#20DayTrends (#G20):

XBB.1.5 (36.6%)⬇️
XBB.1.9.1 (11.5%)⬆️
EG.1 (4.7%)⬆️
XBB.1.16 (4.4%)⬆️
XBB.1.9.2 (3.1%)
XBB.2.3 (1.8%)
XBB.1.5.13 (1.6%)
XBB.1.16.1 (1.5%)

public.tableau.com/app/profile/ra…

Updated 04/29/23

Granular details #Global #20DayTrends

This analysis includes all designated #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 04/09/2023 (14,137 sequences)

#USA, #Austria, #France & #Canada have submitted a lion's share of sequences with sample collection dates on or after 04/09/2023 ...followed by #UnitedKingdom, #Australia, #Germany, #Sweden, #SouthKorea, #Singapore, #China, #Spain

In Silico Immune escape and ACE2 receptor binding scores (relative to BA.2)*

Data is intended to prioritize select lineages to generate rapid laboratory experiments to gauge immune escape and ACE2 binding affinity.

[Credits in the legend] * Only Spike RBD mutations considered

#SARSCoV2 lineages in the zone of concern (red box) - Predicted to have high immune escape and tight ACE2 binding activity - A Closer look

XBB.1.16* family (XBB.1.16.1, FU.1, FU.2, XBB.1.16.2, XBB.1.16.3) cluster together

Chart: public.tableau.com/app/profile/ra…

What to expect in the next few weeks?

github.com/neherlab/SARS-…

Excellent SARSCoV2 Variant report
by @richardneher @CorneliusRoemer

“Currently, XBB.1.16 is the big dog” ... “It’s picking up mutations that are common in other variants that will increase its advantage further.”

H/T @ErinMPrater @WellatFortune
@FortuneMagazine
fortune.com/well/2023/03/3…

A closer look at #Arctrus (XBB.1.16*), #Hyperion (XBB.1.9*) and #Acrux (XBB.2.3*) constellations

more on common names from @TRyanGregory

https://twitter.com/TRyanGregory/status/1652304435383508993